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Keywords: Heart
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Journal Articles
J Cell Sci (2022) 135 (1): jcs259191.
Published: 7 January 2022
.... These minor introns are present in certain gene families with specific functions, such as voltage-gated Na + and voltage-gated Ca 2+ channels. Removal of minor introns by the minor spliceosome has been proposed as a post-transcriptional regulatory layer, which remains unexplored in the heart. Here, we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (15): jcs243162.
Published: 11 August 2020
...-206 deletion shifts slow muscles to a faster profile and results in cardiac dysfunction specifically in male mice. miR-206 miRNA Skeletal muscle Heart Sexual dimorphism Skeletal muscle is a highly organized contractile tissue that comprises 40% of human body mass ( Janssen et al...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (24): 4560–4571.
Published: 15 December 2015
.... The balance of Cdk9 and Larp7 plays a key role in cardiomyocyte proliferation and response to injury. Larp7 represents a potentially novel therapeutic target to promote cardiomyocyte proliferation and recovery from injury. Absence of heart beat and lack of tail blood flow combined with other major...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (5): 1104–1116.
Published: 1 March 2014
... (Cx43, also known as GJA1), cadherin and actin. Vcl and ZO-1 anchor the actin cytoskeleton to the sarcolemma. Given that loss of Vcl from cardiomyocytes causes maldistribution of Cx43 and predisposes cardiomyocyte-specific Vcl-knockout mice with preserved heart function to arrhythmia and sudden death...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (1): 40–49.
Published: 1 January 2014
... 1 10 2013 © 2014. Published by The Company of Biologists Ltd 2014 Myofibroblasts Heart Phenotype switch Fibrosis TGF-β Fibroblast-to-myofibroblast phenoconversion in the heart is a crucial event in the onset of many cardiovascular diseases. Cardiac fibroblasts...
Journal Articles
J Cell Sci (2009) 122 (17): 3070–3082.
Published: 1 September 2009
...) mice, which form no cilia, have ventricular dilation, decreased myocardial trabeculation and abnormal outflow tract development. These data support the conclusion that cardiac primary cilia are crucial in early heart development, where they partly coordinate hedgehog signaling. * Author...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (15): 2503–2510.
Published: 1 August 2008
... complexes that are highly dependent on the developmental context. ‡ Author for correspondence (e-mail: salim@mdc-berlin.de ) * These authors contributed equally to this work 14 5 2008 © The Company of Biologists Limited 2008 2008 Nagie oko Cell polarity Heart...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (12): 2126–2136.
Published: 15 June 2007
... microscopy, that desmosomal proteins in the heart localize not only to the desmosomes in the intercalated discs but also at adhering junctions with hybrid composition. We found that in the latter junctions, endogenous plakophilin-2 colocalizes with αT-catenin. By providing an extra link between the cadherin...
Journal Articles
J Cell Sci (2007) 120 (2): 229–238.
Published: 15 January 2007
... expression and organization during embryonic stem cell differentiation towards cardiomyocyte. We show that the sequence of actin isoform expression displays similar pattern in the in vitro model and in mouse heart embryogenesis. Treatment with an interfering fusion peptide containing the N-terminal sequence...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (16): 3435–3442.
Published: 15 August 2006
... that labeling of this form of Cx43 as well as of total Cx43 is restricted to the intercalated disk region of normal ventricular tissue. In ischemic heart, significant relocalization of total Cx43 to the lateral edges of myocytes was evident; however pS325/328/330-Cx43 remained predominately at the intercalated...
Journal Articles
J Cell Sci (2004) 117 (15): 3295–3306.
Published: 1 July 2004
...Preeti Ahuja; Evelyne Perriard; Jean-Claude Perriard; Elisabeth Ehler The contractile tissue of the heart is composed of individual cardiomyocytes. During mammalian embryonic development, heart growth is achieved by cell division while at the same time the heart is already exerting its essential...
Journal Articles
J Cell Sci (2003) 116 (19): 4001–4009.
Published: 1 October 2003
...Mónica Bettencourt-Dias; Sybille Mittnacht; Jeremy P. Brockes Adult newt cardiomyocytes, in contrast to their mammalian counterparts, can proliferate after injury and contribute to the functional regeneration of the heart. In order to understand the mechanisms underlying this plasticity we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2003) 116 (1): 9–15.
Published: 1 January 2003
... 2003 Nitric oxide Heart Protein targeting PDZ domain The free radical gas nitric oxide (NO) is now recognized as a major messenger molecule that has diverse functions throughout the body. Although originally identified as the endothelial-derived relaxing factor( Furchgott and Zawadzki...
Journal Articles
J Cell Sci (2001) 114 (17): 3167–3176.
Published: 1 September 2001
..., mAKAP may serve as the scaffold for a cAMP- and calcium ion-sensitive signaling complex. *Author for correspondence (e-mail: kapiloff@ohsu.edu ) 25 5 2001 © The Company of Biologists Limited 2001 2001 mAKAP Protein kinase A cAMP Ryanodine receptor Nuclear envelope Heart...
Journal Articles
J Cell Sci (2001) 114 (17): 3177–3188.
Published: 1 September 2001
... cDNA encoding a protein with homology to both human αE(epithelial)-catenin and αN(neural)-catenin. Although originally discovered in testis, αT-catenin is expressed in other tissues, the highest levels being observed in heart. Immunohistochemical analysis showed human αT-catenin localization...