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Keywords: Heart
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Journal Articles
J Cell Sci (2022) 135 (1): jcs259191.
Published: 7 January 2022
.... These minor introns are present in certain gene families with specific functions, such as voltage-gated Na + and voltage-gated Ca 2+ channels. Removal of minor introns by the minor spliceosome has been proposed as a post-transcriptional regulatory layer, which remains unexplored in the heart. Here, we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (15): jcs243162.
Published: 11 August 2020
...-206 deletion shifts slow muscles to a faster profile and results in cardiac dysfunction specifically in male mice. miR-206 miRNA Skeletal muscle Heart Sexual dimorphism Skeletal muscle is a highly organized contractile tissue that comprises 40% of human body mass ( Janssen et al...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (24): 4560–4571.
Published: 15 December 2015
... the two groups ( Fig. 4 B,C), whereas atrial diastolic area was significantly greater in the hearts of embryos that had been injected with the Larp7 morpholinos compared to controls ( Fig. 4 D). Larp7-Mo-SB-injected larvae had a significant reduction in larp7 mRNA by approximately 40% ( Fig. 4 E...
Includes: Supplementary data
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Journal Articles
Journal Articles
J Cell Sci (2009) 122 (17): 3070–3082.
Published: 1 September 2009
...) mice, which form no cilia, have ventricular dilation, decreased myocardial trabeculation and abnormal outflow tract development. These data support the conclusion that cardiac primary cilia are crucial in early heart development, where they partly coordinate hedgehog signaling. The cells were...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (15): 2503–2510.
Published: 1 August 2008
... organs including the heart, retina and neural tube. Many studies have implicated proteins containing PDZ domains in cell polarization ( Sheng and Sala, 2001 ; Bilder et al., 2003 ; Tanentzapf and Tepass, 2003 ; Hurd et al., 2003 ). The membrane-associated guanylate kinase (MAGUK) proteins represent...
Includes: Supplementary data
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J Cell Sci (2007) 120 (2): 229–238.
Published: 15 January 2007
... expression and organization during embryonic stem cell differentiation towards cardiomyocyte. We show that the sequence of actin isoform expression displays similar pattern in the in vitro model and in mouse heart embryogenesis. Treatment with an interfering fusion peptide containing the N-terminal sequence...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (16): 3435–3442.
Published: 15 August 2006
... that labeling of this form of Cx43 as well as of total Cx43 is restricted to the intercalated disk region of normal ventricular tissue. In ischemic heart, significant relocalization of total Cx43 to the lateral edges of myocytes was evident; however pS325/328/330-Cx43 remained predominately at the intercalated...
Journal Articles
J Cell Sci (2004) 117 (15): 3295–3306.
Published: 1 July 2004
...Preeti Ahuja; Evelyne Perriard; Jean-Claude Perriard; Elisabeth Ehler The contractile tissue of the heart is composed of individual cardiomyocytes. During mammalian embryonic development, heart growth is achieved by cell division while at the same time the heart is already exerting its essential...
Journal Articles
J Cell Sci (2003) 116 (19): 4001–4009.
Published: 1 October 2003
...Mónica Bettencourt-Dias; Sybille Mittnacht; Jeremy P. Brockes Adult newt cardiomyocytes, in contrast to their mammalian counterparts, can proliferate after injury and contribute to the functional regeneration of the heart. In order to understand the mechanisms underlying this plasticity we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2003) 116 (1): 9–15.
Published: 1 January 2003
... Nitric oxide Heart Protein targeting PDZ domain The free radical gas nitric oxide (NO) is now recognized as a major messenger molecule that has diverse functions throughout the body. Although originally identified as the endothelial-derived relaxing factor( Furchgott and Zawadzki, 1980...
Journal Articles
J Cell Sci (2001) 114 (17): 3167–3176.
Published: 1 September 2001
..., mAKAP may serve as the scaffold for a cAMP- and calcium ion-sensitive signaling complex. *Author for correspondence (e-mail: kapiloff@ohsu.edu ) 25 5 2001 © The Company of Biologists Limited 2001 2001 mAKAP Protein kinase A cAMP Ryanodine receptor Nuclear envelope Heart...
Journal Articles
J Cell Sci (2001) 114 (17): 3177–3188.
Published: 1 September 2001
... cDNA encoding a protein with homology to both human αE(epithelial)-catenin and αN(neural)-catenin. Although originally discovered in testis, αT-catenin is expressed in other tissues, the highest levels being observed in heart. Immunohistochemical analysis showed human αT-catenin localization...
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J Cell Sci (1999) 112 (16): 2725–2736.
Published: 15 August 1999
... intracellular locations through association with A-kinase anchoring proteins (AKAPs). We now report the cloning of mAKAP, an anchoring protein found predominantly in heart, skeletal muscle and brain, and whose expression is induced in neonatal ventriculocytes by treatment with hypertrophic stimuli. mAKAP...
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Journal Articles
J Cell Sci (1991) 99 (1): 41–44.
Published: 1 May 1991
... propagation, in the mammalian heart. Optical section series obtained by laser scanning confocal microscopy permitted the quantification and mapping of the three-dimensional distribution of gap junctions in ventricular intercalated disks with high clarity over substantial specimen depths. A consistent feature...