... within the epidermal lineage; and orient hair follicles. We also describe how altered polarity signaling contributes to skin cancer. * Author for correspondence ( Carien.niessen@uni-koeln.de ) © 2012. Published by The Company of Biologists Ltd 2012 Polarity Cytoskeleton Signaling...

... and hair follicles. Previously, Rac1 was shown to regulate stem cell behaviour in these compartments. We have asked whether Rac1 has, in addition, a specific, stem-cell-independent function in the regulation of terminal hair follicle differentiation. To address this, we have expressed a constitutively...

...Anne-Catherine Feutz; Yann Barrandon; Denis Monard In hair follicles, dermal papilla (DP) and dermal sheath (DS) cells exhibit striking levels of plasticity, as each can regenerate both cell types. Here, we show that thrombin induces a phosphoinositide 3-kinase (PI3K)-Akt pathway-dependent...

...Uffe Birk Jensen; Xiaohong Yan; Charlotte Triel; Seung-Hyun Woo; Rikke Christensen; David M. Owens The bulge region of adult murine hair follicles harbors epidermal stem cells with multipotent capacity; however, the restricted contributions of these cells under homeostatic conditions indicates...

... keratinocytes of the interfollicular epidermis and in hair follicles. Here we have conditionally knocked out the POZ/BTB transactivation domain of Miz1 in keratinocytes using a keratin 14 (K14)- Cre mouse deleter strain. K14Cre + / Miz1 lox/lox mice have rough fur as a result of altered hair follicle...

... mediated by cathepsin B. J. Biol. Chem. 274 , 33723 -33731. Benavides, F., Starost, M. F., Flores, M., Gimenez-Conti, I. B., Guenet, J. L. and Conti, C. J. ( 2002 ). Impaired hair follicle morphogenesis and cycling with abnormal epidermal differentiation in nackt mice, a cathepsin L-deficient...

...Majlinda Lako; Lyle Armstrong; Paul M. Cairns; Sue Harris; Nicholas Hole; Colin A. B. Jahoda Skin and hair follicle stem cell biology is the focus of increasing interest, not least because the adult hair follicle has well defined dermal and epithelial populations that display distinct developmental...

...Andrei A. Panteleyev; Colin A. B. Jahoda; Angela M. Christiano Recent genetic and molecular studies of hair follicle (HF) biology have provided substantial insight; however, the molecular data, including expression patterns, cannot be properly appreciated without an understanding of the basic...