...Gabriel I. Guajardo-Contreras; Ana L. Abdalla; Alex Chen; Meijuan Niu; Erwan Beauchamp; Luc G. Berthiaume; Alan W. Cochrane; Andrew J. Mouland ABSTRACT Macrophages represent an important viral reservoir in HIV-1-infected individuals. Different from T cells, HIV-1 assembly in macrophages occurs...

...Claire Lacouture; Baptiste Carrio; Cyril Favard; Delphine Muriaux ABSTRACT Cells naturally produce vesicles that bud from different lipid membranes using dedicated molecular machineries. Enveloped RNA viruses, including human immunodeficiency virus type 1 (HIV-1), also generate particles that bud...

.... , da Costa , L. J. and daSilva , L. L. P. ( 2014 ). Interaction of HIV-1 Nef protein with the host protein Alix promotes lysosomal targeting of CD4 receptor . J. Biol. Chem.   289 , 27744 - 27756 . 10.1074/jbc.M114.560193 Austin , C. , Boehm , M. and Tooze , S...

... tuberculosis in primary human lymphatic endothelial cells, HIV-1 in human monocyte-derived macrophages, and the composition of the entotic vacuole. The broad application of this 3D CLEM technique will make it a useful addition to the correlative imaging toolbox for biomedical research. References Armer...

...Levon G. Abrahamyan; Laurent Chatel-Chaix; Lara Ajamian; Miroslav P. Milev; Anne Monette; Jean-François Clément; Rujun Song; Martin Lehmann; Luc DesGroseillers; Michael Laughrea; Graciela Boccaccio; Andrew J. Mouland Human immunodeficiency virus type 1 (HIV-1) Gag selects for and mediates genomic...

... bodies by functioning in the formation of vesicles that bud away from the cytoplasm. Subsequently, a surprising role for ESCRT proteins was defined in the budding step of some enveloped retroviruses, including HIV-1. ESCRT proteins are also employed in this outward budding process, which results...

...G. N. Maertens; P. Cherepanov; A. Engelman Transcriptional co-activator p75 is implicated in human cancer, autoimmunity and replication of human immunodeficiency virus type 1 (HIV-1) as a dominant integrase-interacting protein. Although characterized as chromatin associated, the normal biological...

...Karine Andreau; Jean-Luc Perfettini; Maria Castedo; Didier Métivier; Véronique Scott; Gérard Pierron; Guido Kroemer Cells expressing the human immunodeficiency virus (HIV-1) envelope glycoprotein complex (Env) can fuse with CD4 + cells. When the apoptotic pathway is initiated in Env + cells...

... that probably contributes to the apparent nuclear accumulation of integrase. These results provide new insight into human immunodeficiency virus type 1 integrase intracellular dynamics. It has previously been shown that HIV-1 IN overexpressed in cells is degraded by the N-end rule ( Mulder and Muesing, 2000...

... unknown. The finding that eIF-5A is an essential cofactor of the human immunodeficiency virus type 1 (HIV-1) Rev RNA transport factor suggested that eIF-5A is part of a specific nuclear export pathway. In this study we used indirect immunofluorescence and immunogold electron microscopy to demonstrate...