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Keywords: HIF-1α
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Journal Articles
J Cell Sci (2015) 128 (17): 3317–3329.
Published: 1 September 2015
... controlled by rapid hydroxylation of two proline residues in its α-subunit. However, how the rapid hydroxylation of HIF- is regulated is not fully understood. Here, we report that transient receptor potential canonical (TRPC) 6 channels control hydroxylation and stability of HIF- in human glioma cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2003) 116 (9): 1819–1826.
Published: 1 May 2003
...David Pfander; Thorsten Cramer; Ernestina Schipani; Randall S. Johnson The transcription factor HIF- plays a crucial role in modifying gene expression during low oxygen tension. In a previous study, we demonstrated that HIF- is essential for chondrocyte growth arrest and survival in vivo...
Journal Articles
J Cell Sci (2001) 114 (22): 4051–4061.
Published: 15 November 2001
...Yang-Sook Chun; Eunjoo Choi; Eun-Jin Yeo; Jong Ho Lee; Myung-Suk Kim; Jong-Wan Park The expressions of hypoxia-inducible genes are upregulated by hypoxia-inducible factor 1 (HIF-1), which is a heterodimer of HIF- and HIF-1β/ARNT (aryl hydrocarbon receptor nuclear transporter). Under hypoxic...