...Ilias Mylonis; Maria Kourti; Martina Samiotaki; George Panayotou; George Simos Hypoxia inducible factor-1 (HIF-1) is the main transcriptional activator of the cellular response to hypoxia and an important target of anticancer therapy. Phosphorylation by ERK1 and/or ERK2 (MAPK3 and MAPK1...

...-containing NADPH oxidase in U-II-induced angiogenesis and elucidated a possible contribution of hypoxia-inducible factor-1 (HIF-1), the master regulator of hypoxic angiogenesis, in the response to U-II. We found that U-II increases angiogenesis in vitro and in vivo, and these responses were prevented...

...Alkmini Kalousi; Ilias Mylonis; Anastasia S. Politou; Georgia Chachami; Efrosyni Paraskeva; George Simos Hypoxia-inducible factor 1 (HIF-1), a transcriptional activator that mediates cellular response to hypoxia and a promising target of anticancer therapy, is essential for adaptation to low oxygen...

...Antoine Hubert; Sébastien Paris; Jean-Pascal Piret; Noëlle Ninane; Martine Raes; Carine Michiels HIF-1 (hypoxia-inducible factor-1) is the main transcription factor involved in the adaptation of cells to hypoxia. In addition to regulation of HIF-1α protein level, HIF-1 activity is also enhanced...

..., several studies suggested that oxygen-dependent gene expression is of crucial importance in governing the essential steps of neurogenesis such as cell proliferation, survival and differentiation. In this context, we analysed the effect of the HIF-1 (hypoxia inducible factor-1) activation-mimicking agent...

...Sven Wellmann; Christoph Bührer; Eva Moderegger; Andrea Zelmer; Renate Kirschner; Petra Koehne; Jun Fujita; Karl Seeger The transcriptional regulation of several dozen genes in response to low oxygen tension is mediated by hypoxia-inducible factor 1 (HIF-1), a heterodimeric protein composed of two...