...Zi-Jie Chen; Wan-Ping Wang; Yu-Ching Chen; Jing-Ya Wang; Wen-Hsin Lin; Lin-Ai Tai; Gan-Guang Liou; Chung-Shi Yang; Ya-Hui Chi ABSTRACT Hutchinson-Gilford progeria syndrome (HGPS) is a human progeroid disease caused by a point mutation on the LMNA gene. We reported previously that the accumulation...

..., which is defective in two congenital diseases: Hutchinson-Gilford progeria (HGPS) and restrictive dermopathy (RD). These two diseases arise respectively from defects in the prelamin A substrate and the enzyme (ZmpSte24) that processes it. Recent work has shed light on the roles of the lamin proteins...