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Keywords: Guanine nucleotide exchange factor (GEF)
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Journal Articles
J Cell Sci (2013) 126 (20): 4794–4805.
Published: 15 October 2013
... pathway, Arf1 is involved in recruitment of coats to membranes to form transport vesicles ( Bonifacino and Lippincott-Schwartz, 2003 ). At the cis -Golgi, the Arf1 activator GBF1, a guanine nucleotide exchange factor (GEF) that switches Arf1 from its inactive GDP-bound to active GTP-bound form, recruits...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (2): 461–472.
Published: 15 January 2012
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (10): 1726–1738.
Published: 15 May 2011
... by upregulation of some oncogenic molecules and is closely related to the invasive potential of cancer cells. However, the molecular mechanisms underlying the podosome and invadopodium formation still remain unclear. Here, we show that a guanine nucleotide exchange factor (GEF) for Rho family GTPases (Arhgef5...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2004) 117 (17): 3785–3795.
Published: 01 August 2004
... homology (SH) 2 domains and a single SH3 domain has been implicated in the regulation of many cellular functions. We demonstrate that PLC-γ1 acts as a guanine nucleotide exchange factor (GEF) of dynamin-1, a 100 kDa GTPase protein, which is involved in clathrin-mediated endocytosis of epidermal growth...
Includes: Supplementary data
Journal Articles
J Cell Sci (2001) 114 (12): 2241–2253.
Published: 15 June 2001
...Anne Peyroche; Régis Courbeyrette; Alain Rambourg; Catherine L. Jackson The Sec7 domain guanine nucleotide exchange factors (GEFs) for the GTPase ARF are highly conserved regulators of membrane dynamics. Their precise molecular roles in different trafficking steps within the cell have not been...