...Satoshi Uemura; Takahiro Mochizuki; Kengo Amemiya; Goyu Kurosaka; Miho Yazawa; Keiko Nakamoto; Yu Ishikawa; Shingo Izawa; Fumiyoshi Abe ABSTRACT Mechanical stresses, including high hydrostatic pressure, elicit diverse physiological effects on organisms. Gtr1, Gtr2, Ego1 (also known as Meh1...

...-containing protein Ivy1 colocalizes with Gtr1 and Gtr2, a heterodimer of small GTPases that are part of the EGO complex. Ivy1 is a negative regulator of Gtr-induced TORC1 activation, and is contained within puncta associated with the vacuolar membrane in cells grown in nutrient-rich medium or after brief...

.... Published by The Company of Biologists Ltd 2017 http://www.biologists.com/user-licence-1-1/ Summary: Pib2 and the EGO complex function in the same molecular pathway that leads to the activation of TORC1, a key regulator of cell growth. EGO complex Gtr1 Gtr2 Pib2 TORC1...

...Noelia Valbuena; Kun-Liang Guan; Sergio Moreno The Rag family of GTPases has been implicated in the TORC1 activation in Drosophila and in mammalian cells in response to amino acids. We have investigated the role of the Rag GTPases Gtr1 and Gtr2 in TORC1 regulation in Schizosaccharomyces pombe...