...Hsiao-Wen Su; Nathan J. Lanning; David L. Morris; Lawrence S. Argetsinger; Carey N. Lumeng; Christin Carter-Su Summary Previous studies have shown that growth hormone (GH) recruits the adapter protein SH2B1β to the GH-activated, GH receptor-associated tyrosine kinase JAK2, implicating SH2B1β in GH...

... prolactin or growth hormone. We found that DG regulates signaling by both hormones in a manner that is dependent on laminin-111 binding, but independent of the DG cytoplasmic domain, suggesting that it acts via a co-receptor mechanism reliant on DG-mediated laminin assembly. These results demonstrate...

...Monique J. M. van den Eijnden; Liza L. Lahaye; Ger J. Strous The growth hormone receptor contains seven cysteine residues in its extracellular domain. The six in the growth hormone binding domain form disulfide bonds, and help the receptor to gain its correct three-dimensional structure...

...Thomas K. Graves; Shilpa Patel; Priscilla S. Dannies; Patricia M. Hinkle In some individuals with autosomal dominant isolated growth hormone deficiency, one copy of growth hormone lacks amino acids 32-71 and is severely misfolded. We transfected COS7 cells with either wild-type human growth hormone...

... of the ubiquitin-conjugating system and the endocytic pathway in ligand-induced internalization of the growth hormone receptor . EMBO J . 16 , 4851 – 4858 . 10.1093/emboj/16.16.4851 Govers , R. , van Kerkhof , P. , Schwartz , A. L. and Strous , G. J. ( 1998 ). Di-leucine-mediated...

...Peter D. Vize; Anna E. Michalska; Rod Ashman; B. Lloyd; B. A. Stone; P. Quinn; J. R. E. Wells; R. F. Seamark ABSTRACT Six transgenic pigs have been produced by microinjecting a human metallothionein promoter/porcine growth hormone gene construct into the pronuclei of fertilized eggs which were...