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Keywords: Growth cone
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Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (13): jcs252916.
Published: 08 July 2021
... and mediators of this interpolymer crosstalk, however, are inadequately understood. We identify Fmn2, a non-diaphanous-related formin associated with cognitive disabilities, as a novel regulator of cooperative actin–microtubule remodelling in growth cones of both chick and zebrafish neurons. We show that Fmn2...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (7): jcs251967.
Published: 15 April 2021
... might show different localization in growth cones. We used confocal microscopy to visualize GFP-tagged prenyl-Cdc42 and palm-CDC42 proteins in distal axons of DRG neurons transfected with Cdc42 constructs with or without axonally localizing 3′UTR from Cdc42 exon 7 ( Fig. 6 D, schematics). The protein...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2020) 133 (8): jcs232983.
Published: 24 April 2020
... growth cones . J. Neurosci.   38 , 291 - 307 . 10.1523/JNEUROSCI.2281-17.2017 Buxbaum , R. E. and Heidemann , S. R. ( 1992 ). An absolute rate theory model for tension control of axonal elongation . J. Theor. Biol.   155 , 409 - 426 . 10.1016/S0022-5193(05)80626-5 Chang , S...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (15): 2506–2519.
Published: 01 August 2017
...Szilárd Szikora; István Földi; Krisztina Tóth; Ede Migh; Andrea Vig; Beáta Bugyi; József Maléth; Péter Hegyi; Péter Kaltenecker; Natalia Sanchez-Soriano; József Mihály ABSTRACT Directed axonal growth depends on correct coordination of the actin and microtubule cytoskeleton in the growth cone...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (11): 2331–2341.
Published: 01 June 2013
...Andreas Prokop; Robin Beaven; Yue Qu; Natalia Sánchez-Soriano Summary The extension of long slender axons is a key process of neuronal circuit formation, both during brain development and regeneration. For this, growth cones at the tips of axons are guided towards their correct target cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (22): 5502–5513.
Published: 15 November 2012
... in brain development. * Author for correspondence ( nkabbani@gmu.edu ) 6 8 2012 © 2012. Published by The Company of Biologists Ltd 2012 Gprin Axon growth Proteomics GAP-43 Cytoskeleton Nicotine Neurite Bungarotoxin Growth cone Neuronal development is marked...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (20): 3595–3604.
Published: 15 October 2009
...Sara Geraldo; Phillip R. Gordon-Weeks Interactions between dynamic microtubules and actin filaments are essential to a wide range of cell biological processes including cell division, motility and morphogenesis. In neuronal growth cones, interactions between microtubules and actin filaments...
Journal Articles
J Cell Sci (2007) 120 (21): 3895–3904.
Published: 01 November 2007
... is unknown. The matrix-rigidity response of fibroblasts appears to differ from that of neuronal growth cones but it is unknown whether the rigidity detection mechanism or response pathway is altered. Here, we report that RPTPα is required for rigidity-dependent reinforcement of fibronectin (FN)-cytoskeleton...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (16): 3456–3466.
Published: 15 August 2006
... demonstrated that TN-R induces microprocesses along neurites and enlarged growth cones of tectal cells by interacting with the cell adhesion molecule contactin 1. Here, we describe competition and cooperation between TN-R, lecticans and contactin 1, and their functional consequences for tectal cells. Aggrecan...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (9): 1736–1745.
Published: 01 May 2006
...Ann M. Rajnicek; Louise E. Foubister; Colin D. McCaig Electric fields (EFs) resembling those in the developing and regenerating nervous systems steer growth cones towards the cathode. Requirements for actin microfilaments, microtubules and their interactions during EF growth cone steering have been...
Journal Articles
J Cell Sci (2006) 119 (1): 172–183.
Published: 01 January 2006
...Xiaoxin X. Wang; Karl H. Pfenninger The `signal regulatory protein' SIRPα is an Ig superfamily, transmembrane glycoprotein with a pair of cytoplasmic domains that can bind the phosphatase SHP-2 when phosphorylated on tyrosine. SIRPα is prominent in growth cones of rat cortical neurons and located...
Journal Articles
J Cell Sci (2006) 119 (1): 184–194.
Published: 01 January 2006
..., as well as non-neuronal cells, such as astrocytes and ependymal cells. CAD cells, a neuronal cell line, express both full-length and headless Myo10, and this endogenous Myo10 is present in cell bodies, neurites, growth cones and the tips of filopodia. To investigate the dynamics of the two forms of Myo10...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2003) 116 (18): 3739–3748.
Published: 15 September 2003
...Peter W. Grabham; Boris Reznik; Daniel J. Goldberg Extracellular cues control the rate and direction of growth of neuronal processes in large part by regulating the cytoskeleton of the growth cone. The actin filament network of the peripheral region is thought to be the primary target...
Journal Articles
J Cell Sci (2003) 116 (14): 2823–2832.
Published: 15 July 2003
... by promoting the formation of stress fibers (Rho), lamellipodia (Rac) and filopodia (Cdc42)( Nobes and Hall, 1995 ). In neurons, Rho activation inhibits neurite outgrowth and promotes growth cone collapse and axon retraction ( Dickson,2001 ; Luo, 2000 ; Yuan et al., 2003 ). Rac and Cdc42 play an antagonistic...
Journal Articles
J Cell Sci (2003) 116 (7): 1209–1217.
Published: 01 April 2003
... at the growth cone. This report examines whether this is a regulated event controlled by growth factors. The Golgi complex and nascent PPVs of hippocampal neurons in culture were pulse-labeled with fluorescent ceramide. We studied the dynamics of labeled PPVs upon arrival at the axonal growth cone. In controls...
Journal Articles
J Cell Sci (2003) 116 (2): 239–246.
Published: 15 January 2003
...Motohiro Nozumi; Hiroyuki Nakagawa; Hiroaki Miki; Tadaomi Takenawa; Shigeaki Miyamoto The formation and extension of filopodia in response to an extracellular stimulus by guidance cues determine the path of growth cone advance. Actin-filament bundling and actin polymerization at the tips supply...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (1991) 1991 (Supplement_15): 27–33.
Published: 01 February 1991
...STEPHEN M. STRITTMATTER; DARIO VALENZUELA; TIMOTHY VARTANIAN; YOSHIAKI SUDO; MAURICIO X. ZUBER; MARK C. FISHMAN Summary The neuronal growth cone plays a crucial role in forming the complex brain architecture achieved during development, and similar nerve terminal mechanisms may operate to modify...
Journal Articles
J Cell Sci (1991) 1991 (Supplement_15): 35–44.
Published: 01 February 1991
...STEVEN R. HEIDEMANN; PHILLIP LAMOUREUX; ROBERT E. BUXBAUM Summary Following a brief review of the controversy concerning the physical mechanism of growth cone advance, we present cytomechanical data to support a version of the classic model of growth cone motility. In this model, the growth cone...
Journal Articles
J Cell Sci (1991) 1991 (Supplement_15): 45–49.
Published: 01 February 1991
...PHILLIP R. GORDON-WEEKS Summary Growth cones are transient structures present at the tips of growing axons and dendrites (neurites). They are crucial to neuronal development because of their pathfinding ability and their role in synaptogenesis (reviewed by Dodd and Jessell, 1988). In the last few...