...Di Zhu; Shuo Shi; Hongzhong Wang; Kan Liao The first stage of 3T3-L1 adipocyte differentiation is growth arrest, which is achieved by contact inhibition at confluence. In growth-arrested confluent 3T3-L1 preadipocytes, α-tubulin acetylation and primary-cilium formation were induced. The blockade...

... through modulation of the cell cycle and regulation of cell death. During log-phase growth the rate of proliferation is high and there is a low rate of cell death. As the population density increases, the cell cycle is extended and apoptosis becomes more frequent as the population enters growth arrest...

... assays and STAT luciferase reporter assays, FGF does not activate STAT1 or STAT3 in RCS chondrocytes, which nevertheless respond to a FGF stimulus with potent growth arrest. Moreover, addition of active STAT1 and STAT3 to the FGF signal, by means of cytokine treatment, SRC-mediated STAT activation...

... signaling in chondrocytes. CNP antagonized FGF2-induced growth arrest of rat chondrosarcoma (RCS) chondrocytes by inhibition of the Erk mitogen activated protein kinase pathway. This effect of CNP was protein kinase G-dependent and was mimicked by the cGMP analog pCPT-cGMP. FGF2-mediated activation of both...

... cell lines were compared. Cells expressing wild-type Akt were not susceptible to the growth-arresting effect of NGF, whereas parental PC12 cells and notably cells expressing mutant Akt were so affected. Accompanying this, the expressions of CDKs and p21 WAF1 were down- and up-regulated, respectively...

...Beth L. Harvat; Amy Wang; Prem Seth; A. M. Jetten ABSTRACT Irreversible growth arrest is an early and integral part of squamous cell differentiation in normal human epidermal keratinocytes (NHEKs) and is assumed to be linked to the control of expression of differentiation-specific genes...

...Koichi Kubota; Kazumi Nakazato ABSTRACT Fusion of the YACUT T-cell lymphoma with the Mls-1 a -antigen-specific non-tumorigenic T-cell line G4 was previously reported to produce growth-arrested hybrids that could be induced to proliferate in the presence of Mls-1 a antigen. The proliferation...

...Fred van Ruissen; Piet E. J. van Erp; Gijs J. de Jongh; Jan B. M. Boezeman; Peter C. M. van de Kerkhof; Joost Schalkwijk ABSTRACT In this study we have performed a cell kinetic characterization of growth and growth arrest of keratinocytes derived from normal human skin. Proliferative activity...

...Miriam J. Smyth; Rodney L. Sparks; Walker Wharton * Author for correspondence © 1993 by Company of Biologists 1993 differentiation proliferation adipogenesis growth arrest adipocyte-specific gene expression flow cytometry The relationship between growth arrest...