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Keywords: Golgi
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Journal Articles
J Cell Sci jcs.258807.
Published: 16 September 2021
...Stefan Scholl; Stefan Hilmer; Melanie Krebs; Karin Schumacher The trans-Golgi network/early endosome (TGN/EE) serves as the central hub in which exo- and endocytic trafficking pathways converge and specificity of cargo routing needs to be achieved. Acidification is a hallmark of the TGN/EE...
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2021) 134 (17): jcs259075.
Published: 07 September 2021
..., the MIA3 gene encodes two major forms of transport and Golgi organization protein 1 (TANGO1S and TANGO1L), which have previously been implicated in selective trafficking of procollagen. Using genome engineering of human cells, light microscopy, secretion assays, genomics and proteomics, we show...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (4): jcs258356.
Published: 19 February 2021
... that the spindle assembly factor TPX2 regulates astral microtubules. TPX2 in the spindle pole area is activated by GM130 (GOLGA2) on Golgi membranes to promote astral microtubule growth. GM130 relieves TPX2 inhibition by competing for importin α1 (KPNA2) binding. Mitotic phosphorylation of importin α at serine 62...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (10): jcs241141.
Published: 27 May 2020
... the Golgi, with TRAPPIII also activating RAB1 in autophagosomes. Our finding that Aspergillus nidulans TRAPPII can be assembled by addition of a TRAPPII-specific subcomplex onto core TRAPP prompted us to investigate the possibility that TRAPPI and/or TRAPPIII already residing in the Golgi matures...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (21): jcs232389.
Published: 01 November 2019
... have identified Golgi proteins as SIRT2 interactors, indicating that SIRT2 may also play a role in Golgi structure formation. Here, we show that SIRT2 depletion causes Golgi fragmentation and impairs Golgi reassembly at the end of mitosis. SIRT2 interacts with the Golgi reassembly stacking protein...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (20): jcs222992.
Published: 21 October 2019
... is associated with the trans-Golgi network (TGN) and early and/or recycling endosomes, whereas AP-2 is located at the plasma membrane ( Robinson, 2015 ) (see poster). Both AP-1 and AP-2 are heterotetramers, consisting of two large (∼100 kDa) subunits, γ and β1 in the AP-1 complex, and α and β2 in the AP-2...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (17): jcs230672.
Published: 06 September 2019
...Bhawik Kumar Jain; Roma Dahara; Dibyendu Bhattacharyya ABSTRACT The adhesive force for cisternal stacking of Golgi needs to be reversible – to be initiated and undone in a continuous cycle to keep up with the cisternal maturation. Microscopic evidence in support of such a reversible nature...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (16): jcs231886.
Published: 22 August 2019
...-translational modifications, H-Ras and N-Ras traffic to the PM from the Golgi via the classical exocytic pathway, but the exact mechanism of K-Ras trafficking to the PM from the ER is not fully characterized. ATP5G1 (also known as ATP5MC1) is one of the three proteins that comprise subunit c of the F 0 complex...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2019) 132 (3): jcs225557.
Published: 01 February 2019
... of the Golgi depends on its association with a septin 1 (SEPT1)-based scaffold, which promotes local microtubule nucleation and positioning of the Golgi. SEPT1 function depends on the Golgi matrix protein GM130 (also known as GOLGA2) and on centrosomal proteins, including CEP170 and components of γ-tubulin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (16): jcs215855.
Published: 17 August 2018
...Vibha Singh; Chaitanya Erady; Nagaraj Balasubramanian ABSTRACT Cell-matrix adhesion regulates membrane trafficking controlling anchorage-dependent signaling. While a dynamic Golgi complex can contribute to this pathway, its regulation by adhesion remains unclear. Here we report that loss...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (10): jcs212522.
Published: 23 May 2018
... show that VLDLR is required for mPR trafficking from the endoplasmic reticulum to the Golgi. Taken together, our data define a novel function for the VLDLR as a trafficking chaperone required for the mPR subcellular localization and, as such, non-genomic progesterone-dependent signaling. This article...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2018) 131 (9): jcs212258.
Published: 04 May 2018
... as the most strongly upregulated gene from a comparative RNAseq analysis of cells in which expression of the Golgi matrix protein giantin had been abolished by gene editing. In contrast to previous work where we showed that depletion of giantin by RNAi results in defects in ciliogenesis and in cilia length...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (4): jcs208199.
Published: 19 April 2018
...Douglas Quilty; Calvin J. Chan; Katherine Yurkiw; Alexandra Bain; Ghazal Babolmorad; Paul Melançon ABSTRACT We previously proposed a novel mechanism by which the enzyme Golgi-specific Brefeldin A resistance factor 1 (GBF1) is recruited to the membranes of the cis -Golgi, based on in vivo...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (5): jcs209890.
Published: 13 March 2018
...Eric C. Arakel; Blanche Schwappach ABSTRACT The coat protein complex I (COPI) allows the precise sorting of lipids and proteins between Golgi cisternae and retrieval from the Golgi to the ER. This essential role maintains the identity of the early secretory pathway and impinges on key cellular...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (3): jcs210245.
Published: 05 February 2018
... understood. We probed Golgi recruitment of GBF1, a GEF catalyzing ARF activation required for Golgi homeostasis. We show that the homology downstream of Sec7d-1 (HDS1) regulates Golgi recruitment of GBF1. We document that GBF1 binds phosphoinositides, preferentially PI3P, PI4P and PI(4,5)P 2 , and that lipid...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (2): jcs203893.
Published: 29 January 2018
...Yoko Ito; Tomohiro Uemura; Akihiko Nakano; Jenny Russinova ABSTRACT Many questions remain about how the stacked structure of the Golgi is formed and maintained. In our previous study, we challenged this question using tobacco BY-2 cells and revealed that, upon Brefeldin A (BFA) treatment...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (2): jcs203802.
Published: 29 January 2018
.... A quadruple loss-of-function mutant affecting the p24 genes from the δ-1 subclass of the p24δ subfamily ( p24δ3δ4δ5δ6 ) showed alterations in the Golgi, suggesting that these p24 proteins play a role in the organization of the compartments of the early secretory pathway in Arabidopsis . Loss of p24δ-1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (3): jcs208017.
Published: 29 January 2018
... of Rheb is controversial. In this study, we showed that a significant portion of Rheb is localized on the Golgi but not on the lysosome. GFP–Rheb could activate mTORC1, even when forced to exclusively localize to the Golgi. Likewise, artificial recruitment of mTORC1 to the Golgi allowed its activation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (24): 4155–4167.
Published: 15 December 2017
... cells couple increased cargo load with a coordinate rise in secretory capacity to ensure efficient transport is not well understood. We used thyroid cells stimulated with thyrotropin (TSH) to demonstrate a coordinate increase in the production of thyroid-specific cargo proteins and ER–Golgi transport...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (24): 4132–4143.
Published: 15 December 2017
...Nicola L. Stevenson; Dylan J. M. Bergen; Roderick E. H. Skinner; Erika Kague; Elizabeth Martin-Silverstone; Kate A. Robson Brown; Chrissy L. Hammond; David J. Stephens ABSTRACT The Golgi is the cellular hub for complex glycosylation, controlling accurate processing of complex proteoglycans...
Includes: Supplementary data