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Keywords: Glycosylation
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Journal Articles
J Cell Sci (2022) 135 (1): jcs258879.
Published: 13 January 2022
... complex Collagen Extracellular matrix Glycosylation Proteoglycans Secretory pathway Biotechnology and Biological Sciences Research Council http://dx.doi.org/10.13039/501100000268 BB/T001984/1 University of Manchester http://dx.doi.org/10.13039/501100000770...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (22): jcs259340.
Published: 25 November 2021
...Marcel van Lith; Marie Anne Pringle; Bethany Fleming; Giorgia Gaeta; Jisu Im; Reid Gilmore; Neil J. Bulleid ABSTRACT N-linked glycosylation of proteins entering the secretory pathway is an essential modification required for protein stability and function. Previously, it has been shown...
Journal Articles
J Cell Sci (2021) 134 (9): jcs257592.
Published: 11 May 2021
...Meghana Bhimreddy; Emma Rushton; Danielle L. Kopke; Kendal Broadie ABSTRACT The synaptic cleft manifests enriched glycosylation, with structured glycans coordinating signaling between presynaptic and postsynaptic cells. Glycosylated signaling ligands orchestrating communication are tightly...
Journal Articles
J Cell Sci (2020) 133 (20): jcs245845.
Published: 23 October 2020
... and intrinsic factors. Mucin-type O -glycosylation has been suggested to be a potential factor in the control of ESC pluripotency, and is characterized by the addition of N -acetylgalactosamine (GalNAc) to serine or threonine residues of membrane-anchored proteins and secreted proteins. To date...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (20): jcs232058.
Published: 23 October 2019
... or to parental cells. Further, treatment of cells expressing membranous NIS with specific glycosylation inhibitors highlighted the importance of inherent glycosylation processing and an 84 gene signature glycosylation RT-Profiler array revealed that clones expressing NIS in their membrane cluster separately...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (16): jcs215855.
Published: 17 August 2018
... to loss of adhesion. Adhesion-dependent Arf1 activation regulates its binding to the microtubule minus-end motor protein dynein to control Golgi reorganization, which is blocked by ciliobrevin. Adhesion-dependent Golgi organization controls its function, regulating cell surface glycosylation due to loss...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (9): jcs208884.
Published: 01 May 2018
... migration, autophagy and signalling. Endocytosis Galectin Glycosylation Galectins were discovered based on their galactoside binding activity, in a quest to find proteins that decode complex cell-surface glycans. They were defined as a protein family based on conserved β-galactoside-binding...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (24): 4132–4143.
Published: 15 December 2017
...Nicola L. Stevenson; Dylan J. M. Bergen; Roderick E. H. Skinner; Erika Kague; Elizabeth Martin-Silverstone; Kate A. Robson Brown; Chrissy L. Hammond; David J. Stephens ABSTRACT The Golgi is the cellular hub for complex glycosylation, controlling accurate processing of complex proteoglycans...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (21): 3637–3649.
Published: 01 November 2017
...Anna Frappaolo; Stefano Sechi; Tadahiro Kumagai; Sarah Robinson; Roberta Fraschini; Angela Karimpour-Ghahnavieh; Giorgio Belloni; Roberto Piergentili; Katherine H. Tiemeyer; Michael Tiemeyer; Maria Grazia Giansanti ABSTRACT Congenital disorders of glycosylation (CDG) comprise a family of human...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (19): 3234–3247.
Published: 01 October 2017
... involved in N-linked glycosylation, regulators of ER-Golgi trafficking and proteins involved in immunity. The results of this screening approach led us to address the controversial role of N-linked glycosylation in the transport of Gal-3 to the cell surface. We find that N-linked glycoprotein maturation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (13): 2213–2219.
Published: 01 July 2015
... complexes that crosslink glycosylated ligands to form a dynamic lattice. The galectin lattice regulates the diffusion, compartmentalization and endocytosis of plasma membrane glycoproteins and glycolipids. The galectin lattice also regulates the selection, activation and arrest of T cells, receptor kinase...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (5): 1051–1063.
Published: 01 March 2015
.... S.M. performed immunofluorescence analyses. T.K. carried out the apical-basolateral sorting assay. T.S. performed the fractionation assay. C.A. and T.T. analyzed the glycosylation and lipidation profiles of Wnt5a by mass spectrometry and provided advice. A.K. designed the experiments and wrote...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (23): 5014–5026.
Published: 01 December 2014
...Andrew G. McDonald; Jerrard M. Hayes; Tania Bezak; Sonia A. Głuchowska; Eoin F. J. Cosgrave; Weston B. Struwe; Corné J. M. Stroop; Han Kok; Teun van de Laar; Pauline M. Rudd; Keith F. Tipton; Gavin P. Davey ABSTRACT Protein N-glycosylation is a common post-translational modification that produces...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (13): 2931–2943.
Published: 01 July 2013
.... Although Wntless (Wls) has been shown to interact with Wnts and support their secretion, the role of Wls in the sorting of Wnts to the final destination in polarized epithelial cells have not been clarified. Glycosylation was shown to be important for the sorting of some transmembrane and secreted proteins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (10): 2478–2485.
Published: 15 May 2012
...Matthew D. Langer; Huabei Guo; Nitesh Shashikanth; J. Michael Pierce; Deborah E. Leckband We present direct evidence that the N-glycosylation state of neural cadherin impacts the intrinsic kinetics of cadherin-mediated intercellular binding. Micropipette manipulation measurements quantified...
Journal Articles
J Cell Sci (2011) 124 (9): 1363–1372.
Published: 01 May 2011
... of neuronally expressed IFs and their protein–protein interactions, as well as IF glycosylation, which not only has a role in stress and ageing, but might also regulate IFs during development. Although many of these recent findings are still preliminary, they nevertheless open new doors to explore...
Journal Articles
J Cell Sci (2009) 122 (4): 443–452.
Published: 15 February 2009
...Catherine L. Jackson The Golgi complex is the central sorting and processing station of the secretory pathway, ensuring that cargo proteins, which are synthesized in the endoplasmic reticulum, are properly glycosylated and packaged into carriers for transport to their final destinations. Two recent...
Journal Articles
J Cell Sci (2008) 121 (17): 2814–2823.
Published: 01 September 2008
... fibrosis, ΔF508, is misfolded and retained by ER quality control. As oligosaccharide moieties of glycoproteins are known to mediate interactions with ER lectin chaperones, we investigated the role of N-linked glycosylation in the processing of wild-type and ΔF508 CFTR. We found that N-glycosylation and ER...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (4): 625–635.
Published: 15 February 2006
... galactosyltransferase (GT) and galactosylhydroxylysyl glucosyltransferase (GGT) activities in vitro. To investigate the in vivo importance of LH3-catalyzed lysine hydroxylation and hydroxylysine-linked glycosylations, three different LH3-manipulated mouse lines were generated. Mice with a mutation that blocked only...
Journal Articles
J Cell Sci (2006) 119 (2): 199–207.
Published: 15 January 2006
... of posttranslational processing for dystroglycan function. Glycosylation is the crucial modification that modulates the function of dystroglycan as a receptor for extracellular binding partners. It has become clear that perturbation of dystroglycan glycosylation is the central event in the pathogenesis of several...