...Yulu Cherry Liu; Bradley M. Wierbowski; Adrian Salic ABSTRACT Glypicans are a family of cell surface heparan sulfate proteoglycans that play critical roles in multiple cell signaling pathways. Glypicans consist of a globular core, an unstructured stalk modified with sulfated glycosaminoglycan...

... in the extracellular matrix through interaction with specific sequences of glycosaminoglycan oligosaccharides, mainly heparan sulfate (HS). Different HS subspecies revealed by specific antibodies, have been shown to provide spatiotemporal regulation during muscle development. We have previously shown...

...Nigel J. Klein; Graham I. Shennan; Robert S. Heyderman; Michael Levin ABSTRACT There is increasing evidence that the glycosaminoglycan (GAG) component of the vascular endothelium is important in regulating vascular permeability, throm-boresistance and cellular interactions. We have investigated...

...Michael Edward; Rona M. MacKie ABSTRACT The effect of all- trans retinoic acid on metastatic B16 melanoma lung colonization and synthesis and properties of glycosaminoglycans was examined. Injection of tumour cells, pretreated with 10 −6 M-retinoic acid or grown to low density, into the tail vein...

...Françoise Bouziges; Patricia Simon-Assmann; Cathy Leberquier; Katy Haffen; Michèle Kedinger ABSTRACT The nature and distribution of newly synthesized glycosaminoglycans (GAGs) were studied in foetal rat skin fibroblasts, in rat intestinal endodermal cells and in cocultures of both cell types...

...R. Docherty; J. V. Forrester; J. M. Lackie; D. W. Gregory ABSTRACT The effect of glycosaminoglycans on the invasion of choroid fibroblasts into type I collagen gels was studied. Both hyaluronate and chondroitin sulphate, when incorporated into the gel, facilitated invasion of the collagen matrix...

...Michael Edward ABSTRACT The effect of ascorbate on the glycosaminoglycans synthesized by normal and simian virus 40(SV40)-transformed human skin fibroblasts was examined. Cells were incubated in the presence or absence of ascorbate, and radiolabelled with [ 3 H]glucosamine and [ 35 S]sulphate...

... of regeneration of extracellular matrix. 02 01 1986 25 03 1986 © 1986 by Company of Biologists 1986 collagen extracellular matrix fibroblasts glycosaminoglycans immunocytochemistry wound healing Wound healing and tissue regeneration consist of complex events, many of which...