... as a prominent metabolic phenotype, in contrast to what is seen for cranial NCCs, which instead rely on aerobic glycolysis. In addition, only one pathway downstream of glucose uptake is not sufficient for trunk NCC development. Indeed, glycolysis, mitochondrial respiration and the pentose phosphate pathway...

... morphology and lack of fission, patient cells display lower coupling efficiency, increased proton leak and upregulation of glycolysis. Mitochondrial hyperfusion also results in aberrant cristae structure and hyperpolarized mitochondrial membrane potential. Peroxisomes show a severely elongated morphology...

...Gregory G. Fuller; John K. Kim ABSTRACT Hypoxia inhibits the tricarboxylic acid (TCA) cycle and leaves glycolysis as the primary metabolic pathway responsible for converting glucose into usable energy. However, the mechanisms that compensate for this loss in energy production due to TCA cycle...

... target for manipulating the microvasculature. Recent studies show that endothelial cells rely on glycolysis for ATP production, and that the key glycolytic regulator 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) regulates angiogenesis by controlling the balance of tip versus stalk cells...

...-phosphate isomerase to the autocrine motility factor receptor gp78 ( Niinaka et al., 1998 ). The potential for glycolytic enzymes to perform crucial functions dramatically independent from their roles in glycolysis is evident ( reviewed by Kim and Dang, 2005 ). Our findings are particularly relevant as TPI...

... that the location of lysosomes is an inherently important aspect of invasion by tumor cells. * Author for correspondence ( [email protected] ) 25 1 2010 © 2010. 2010 Lysosome trafficking HGF EIPA Rab7 RILP Cell invasion Cathepsin secretion Glycolysis NHE1 ORP1L...

... of NO. The mitochondrial defect and stabilization of HIF1α synergize to activate glycolysis, which, at its maximum, generates quantities of ATP greater than those produced by non-activated cells. Nevertheless, the amount of ATP generated is not sufficient to fulfil the energy requirements of the activated cells, probably...

...Cristina Guerra-Giraldez; Luis Quijada; Christine E. Clayton All kinetoplastids contain membrane-bound microbodies known as glycosomes,in which several metabolic pathways including part of glycolysis are compartmentalized. Peroxin 2 is essential for the import of many proteins into the microbodies...

... 1997 © 1997 by Company of Biologists 1997 Autophagy Peroxisome Alcohol oxidase Formate dehydrogenase Protein turnover Glycolysis Vacuole Nutrient adaptation The construction of WDKO1 ( his4, pfk1 :: ARG4 ) cells was done by disrupting the PFK1 gene of PPF1 ( his4, arg4...

... suggests that ATP-production in the principal piece mainly occurs by glycolysis and in the midpiece by respiration. After sperm disintegration in various salt buffer solutions (Na/K-phosphate, Tris-HCl or imidazole; 100 mMol/l; pH 7.3) more than 90% of total boar sperm GAPDH activity was found...

...M. A. Aon; S. Cortassa; H. V. Westerhoff; J. A. Berden; E. Van Spronsen; K. Van Dam ABSTRACT The control exerted in vivo by mitochondrial functions on the dynamics of glycolysis was investigated in starved yeast cells that were metabolizing glucose semianaerobically. Glycolytic oscillations were...

... in pattern and in timing the rate of production of CO 2 established in earlier papers. This suggests a coordinate control of the flux through glycolysis and the activity of the last enzyme in the glycolytic pathway in yeast However, an interesting difference indicating a loss of the coordinate control...