...Gisela I. Mazaira; Pablo C. Echeverria; Mario D. Galigniana ABSTRACT It has been demonstrated that tetratricopeptide-repeat (TPR) domain proteins regulate the subcellular localization of glucocorticoid receptor (GR). This study analyses the influence of the TPR domain of high molecular weight...

... of the glucocorticoid receptor (GR) by using fluorescence recovery after photobleaching and single-molecule microscopy. First, we have described the dynamic states in which the GR occurs. Second, we have analyzed the transitions between these states by using a continuous-time Markov chain model and functionally...

...Takashi Okabe; Rohit Chavan; Sara S. Fonseca Costa; Andrea Brenna; Jürgen A. Ripperger; Urs Albrecht ABSTRACT REV-ERBα (encoded by Nr1d1 ) is a nuclear receptor that is part of the circadian clock mechanism and regulates metabolism and inflammatory processes. The glucocorticoid receptor (GR...

...Judith Toneatto; Sergio Guber; Nancy L. Charó; Sebastián Susperreguy; Jessica Schwartz; Mario D. Galigniana; Graciela Piwien-Pilipuk Summary Glucocorticoids play an important role in adipogenesis through the glucocorticoid receptor (GR) that forms a heterocomplex with Hsp90•Hsp70 and one high...

... ; Loechner et al., 1999 ). Dexamethasone, a potent synthetic GC, inhibits ACTH-release in this cell line in less than 10 minutes ( Loechner et al., 1999 ). The existence of a membrane glucocorticoid receptor (mGR) was suggested as the result of binding studies of isolated AtT-20 cell membranes...

... that express an exogeneous glucocorticoid receptor (GR). Electrical, fluorescence and nano-imaging techniques are applied to study the permeability and the structure of the NE at 5 and 60 minutes after injection of TA. A remarkable dilation of nuclear pore complexes (NPCs), a rearrangement of NPC distribution...

... transcription by maintaining NF- κ B in the cytoplasm. Proteins from other pathways are also known to regulate NF- κ B negatively, notably the glucocorticoid receptor (GR) and IL-4-responsive STAT6. Both pathways were shown to inhibit NF- κ B-mediated transcription, by expressing either STAT6 or GR...

... genes, such as those coding for c-Jun and the glucocorticoid receptor, was enhanced significantly relative to actin. Nuclear runoff transcription assays using HeLa cells showed that the effect is caused by increased transcription rates rather than mRNA stabilization. Activation of transcription by Hap50...