...Yao Xiao; Mingliang Li; Teng Ma; Hao Ning; Libo Liu ABSTRACT AMG232 effectively inhibits cancers with wild-type p53 (also known as TP53) by reactivating p53, but whether it inhibits glioma angiogenesis remains unclear. This study confirms that AMG232 inhibits the proliferation of glioma endothelial...

...Shruti Patrick; Pruthvi Gowda; Kirti Lathoria; Vaishali Suri; Ellora Sen ABSTRACT Mutation of the isocitrate dehydrogenase 1 ( IDH1 ) gene leads to the production of oncometabolite D-2-hydroxyglutarate (2-HG) from α-ketoglutarate and is associated with better prognosis in glioma. As Yes-associated...

... mouse model, differential YAP expression in glioma cells promotes tumorigenesis and leads to clonal dominance by cells expressing more YAP. Such clonal dominance also occurs in vitro when cells reach confluence in the two-dimensional culture condition or grow into tumor spheroids. During this process...

..., are reviewed. Glioma Mechanobiology Mechanotransduction Microenvironment Neurodegeneration Differentiated tissues exhibit distinct mechanical properties ( Fig. 1 ), which direct their structure and function and reflect the composition and architecture of the extracellular matrix (ECM...

... is established; however, their role in non-neuronal cells is poorly defined. As brain tumors are enriched in the neurotransmitter glycine, we studied the expression and function of glycine receptors (GlyRs) in glioma cells. Human brain tumor biopsies selectively expressed the GlyR α1 and α3 subunits, which have...

... secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C.   J. Cell Biol.   189 , 223 – 232 . 10.1083/jcb.200911018 Hu   B. , Shi   B. , Jarzynka   M. J. , Yiin   J. J. , D'Souza–Schorey   C. , Cheng   S. Y. ( 2009 ). ADP-ribosylation factor 6 regulates glioma cell...

... of Nm23 in gliomas and its effect on migration and invasion in vitro.   Anticancer Res.   26 , 249 – 258 . Kataoka   H. , Tanaka   M. , Kanamori   M. , Yoshii   S. , Ihara   M. , Wang   Y. J. , Song   J. P. , Li   Z. Y. , Arai   H. , Otsuki   Y. , et al ( 2002...

... in human glioma samples and purified glioma cells. Using a wound-healing assay, we show that a decreased level of N-cadherin promotes a faster and less-directed migration both in normal and tumour cells. N-cadherin-mediated contacts control cell velocity and polarity through the regulation of focal...

... to initiators of apoptosis or whether it is functionally significant is not clear. In this study, we sought to answer this question using human malignant glioma cells as a model system. In vivo, high grade gliomas demonstrate an increased percentage of apoptotic cells as well as upregulation of death ligand...

...Anna M. Joy; Christian E. Beaudry; Nhan L. Tran; Francisco A. Ponce; David R. Holz; Tim Demuth; Michael E. Berens Glioma cells that migrate out of the main tumor mass into normal brain tissue contribute to the failure of most gliomas to respond to treatment. Treatments that target migratory glioma...

.... Chen, B., Borinstein, S. C., Gillis, J., Sykes, V. W. and Bogler, O. ( 2000 ). The glioma associated protein SETA interacts with AIP1/Alix and ALG-2 and modulates apoptosis in astrocytes. J. Biol. Chem. 275 , 19275 -19281. Dikic, I. ( 2002 ). CIN85/CMS family of adaptor molecules. FEBS Lett...

..., however, are poorly elucidated. We show here that expression of or exposure to the neural cell adhesion molecule (NCAM) strongly affected the motile behaviour of glioma cells independently of homophilic NCAM interactions. Expression of the transmembrane 140 kDa isoform of NCAM (NCAM-140) caused...

... ) 03 10 2000 07 11 2000 © 2000 by Company of Biologists 2000 p125FAK Astrocytoma Glioma Glioblastoma Proliferation Migration Vitronectin It has been established in vitro that cell contacts with the extracellular matrix that are mediated through the integrin family...