...Atanu Ghorai; Bhawna Singh; Shilpee Dutt ABSTRACT Therapy-induced senescence (TIS) in glioblastoma (GBM) residual disease and escape from TIS account for resistance and recurrence, but the mechanism of TIS manifestation remains obscure. Here, we demonstrate that replication stress (RS) is critical...

...Jyothi Nair; Safiulla Basha Syed; Tejashree Mahaddalkar; Madhura Ketkar; Rahul Thorat; Jayant Sastri Goda; Shilpee Dutt ABSTRACT Glioblastoma (GBM) has poor median survival due to its resistance to chemoradiotherapy, which results in tumor recurrence. Recurrent GBMs currently lack effective...

...Xiaoyun Li; Renza Spelat; Anna Bartolini; Daniela Cesselli; Tamara Ius; Miran Skrap; Federica Caponnetto; Ivana Manini; Yili Yang; Vincent Torre ABSTRACT Glioblastoma (GBM) is one of the most malignant brain tumours and, despite advances in treatment modalities, it remains largely incurable. Ca 2...

...Gilles Breuzard; Alessandra Pagano; Sonia Bastonero; Soazig Malesinski; Fabrice Parat; Pascale Barbier; Vincent Peyrot; Hervé Kovacic ABSTRACT The pathological significance of Tau (encoded by MAPT ) in mechanisms driving cell migration in glioblastoma is unclear. By using an shRNA approach...

... (EDB), referred to as EDA+FN or EDB+FN, are highly upregulated in tumor vasculature. Transforming growth factor β (TGF-β) signaling has been attributed a pivotal role in glioblastoma, with TGF-β promoting angiogenesis and vessel remodeling. By using immunohistochemistry staining, we observed...

...Eishu Hirata; Hiroko Yukinaga; Yuji Kamioka; Yoshiki Arakawa; Susumu Miyamoto; Takaharu Okada; Erik Sahai; Michiyuki Matsuda Two-photon excitation microscopy was used to visualized two different modes of invasion at perivascular and intraparenchymal regions of rat C6 glioblastoma cells that were...

... originating from glial cells; however, the expression of OLIG2 is rare or weak in glioblastomas, the most malignant gliomas. The role of OLIG2 in glioma remains unclear. To investigate the function of OLIG2 in glial tumor cells, we have established a glioblastoma cell line, U12-1, in which the expression...

... in U-251 glioblastoma cells. Immunoprecipitates of endogenous Beclin 1 contained human Vps34 (hVps34), but not Bcl-2. Suppression of Beclin 1 expression by short interfering (si)RNA-mediated gene silencing blunted the autophagic response of the cells to nutrient deprivation or C 2 -ceramide. However...

... ) 03 10 2000 07 11 2000 © 2000 by Company of Biologists 2000 p125FAK Astrocytoma Glioma Glioblastoma Proliferation Migration Vitronectin It has been established in vitro that cell contacts with the extracellular matrix that are mediated through the integrin family...