...Eugenia Guida; Valentina Tassinari; Ambra Colopi; Federica Todaro; Valeriana Cesarini; Benedetto Jannini; Manuela Pellegrini; Flavia Botti; Gabriele Rossi; Pellegrino Rossi; Emmanuele A. Jannini; Susanna Dolci ABSTRACT Germ cell tumors (GCTs) are rare tumors that can develop in both sexes, peaking...

...Lauren G. Chukrallah; Aditi Badrinath; Gabrielle G. Vittor; Elizabeth M. Snyder ABSTRACT Male germ cells establish a unique heterochromatin domain, the XY-body, early in meiosis. How this domain is maintained through the end of meiosis and into post-meiotic germ cell differentiation is poorly...

... frequency. Our results show that the excess dedifferentiation is likely due to misregulation of nos , a key regulator of germ cell identity and GSC maintenance. Taken together, our data reveal negative regulation of dedifferentiation to balance stem cell maintenance with differentiation. * Author...

...Cristina Ottone; Silvia Gigliotti; Angela Giangrande; Franco Graziani; Arturo Verrotti di Pianella Summary In Drosophila , germ cell formation depends on inherited maternal factors localized in the posterior pole region of oocytes and early embryos, known as germ plasm. Here, we report...

... specifically expressed in germ cells, are involved in spermatogonia and oocyte differentiation. In the male, deletion of each factor causes loss of Kit-expressing spermatogonia in the prepuberal testis. In the female, SOHLH1 and SOHLH2 ablations cause oocyte loss in the neonatal ovary. To investigate whether...

... is expressed by Sertoli cells in the seminiferous epithelium, mainly during the stages where phagocytosis takes place. Using a Sertoli-derived cell line, we show that addition of germ cells and residual bodies triggers a re-localization of CD36 from the cytoplasm to the plasma membrane of the cells, while...

... The Company of Biologists Limited 2005 2005 Synaptonemal complex Germ cells Meiosis Gametogenesis Recombination Formation of the synaptonemal complex (SC) is a key step of meiosis. The SC is a zipper-like structure composed of two lateral elements (LEs) that are joined together by transverse...

... and the telomerase RNA template. The increase of telomerase activity by Kitl is blocked by the presence of the PI3K inhibitor LY294002. Kit-positive proliferating male primordial germ cells (PGCs) show low levels of telomerase activity, but they increase telomerase activity upon Kitl stimulation. Diplotene-arrested...

... state, whereas they appear decondensed in the Robertsonian homozygotes. As the Robertsonian heterozygosities we studied produce a chromosomally derived impairment of male germ-cell differentiation, we discuss the possibility that changes in chromosome spatial territories may alter some nuclear machinery...