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Keywords: Genome stability
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Journal Articles
J Cell Sci (2020) 133 (1): jcs240754.
Published: 08 January 2020
... of research have yielded versatile molecular methods to control the expression of native and foreign genes in this species. Fission yeast Schizosaccharomyces pombe Genome stability Integrative vector Molecular genetics Summary: We establish a new vector series to efficiently and stably...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (12): jcs211433.
Published: 27 June 2018
... in a cysteine-rich domain of the chromokinesin KIF4A is an important determinant of its correct localization to its functional sites during mitosis. Chromokinesin Fe-S cluster Genome stability Recent studies have attempted to expand the list of genes contributing to chromosome instability (CIN...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (12): jcs215525.
Published: 21 June 2018
... of DIPG, our results suggest a new model by which H3K27me2/3 facilitates NHEJ and the maintenance of genome stability. This article has an associated First Person interview with the first author of the paper . Genome instability is a hallmark of tumour progression ( Hanahan and Weinberg, 2011 ; Zhao et...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (6): 1134–1146.
Published: 15 March 2017
... repeat domain requires further ATM or ATR activity. Thus, NIPBL has evolved a sophisticated response to damaged DNA that is influenced by the form of damage, suggesting a highly dynamic role for NIPBL in maintaining genomic stability. * Author for correspondence ( lena.strom@ki.se ) Competing...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (13): 2910–2919.
Published: 01 July 2014
... (Ccdc13) in a genome-wide RNA interference screen for regulators of genome stability. We establish that Ccdc13 is a newly identified centriolar satellite protein that interacts with PCM1, Cep290 and pericentrin and prevents the accumulation of DNA damage during mitotic transit. Depletion of Ccdc13 results...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (11): 2460–2470.
Published: 01 June 2014
... 14 02 2014 © 2014. Published by The Company of Biologists Ltd 2014 Genome stability Ribonucleotide reductase CRL4 Cdt2 ubiquitin ligase Intrinsically disordered proteins S. pombe Cancer model Correct regulation of the levels of the building blocks of DNA is emerging...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (20): 4770–4779.
Published: 15 October 2012
... and division. Cep131 has recently been described as a basal body component essential for cilium formation, but its function in non-ciliogenic cells is unknown. We identified human Cep131 (also known as AZI1) in a screen for regulators of genome stability. We show that centrosomal localisation of Cep131 is cell...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (22): 4013–4025.
Published: 15 November 2009
... of Biologists Limited 2009 2009 Telomeres Telomerase Shelterin ALT Aging Recombination Genome stability Consistent with the essential roles of TRF1 and TRF2 in chromosome-end protection, homozygous inactivation of either gene results in early embryonic lethality in mice ( Celli and de Lange...
Journal Articles
J Cell Sci (2009) 122 (12): 1990–2002.
Published: 15 June 2009
...) displayed polyploidy (8n chromosomes) ( Fig. 6A ), suggesting a defective chromosome segregation or cytokinesis. We next evaluated the consequences of PARG depletion on genome stability by monitoring telomeric aberrations using telomeric FISH analyses in cells either left untreated or 24 hours after...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (8): 1258–1267.
Published: 15 April 2009
... in the maintenance of genome stability in all organisms that have been examined. Although genetic alterations in the RECQL4 gene are reported to be associated with three autosomal recessive disorders (Rothmund-Thomson, RAPADILINO and Baller-Gerold syndromes), the molecular role of RECQL4 still remains poorly...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (23): 3933–3940.
Published: 01 December 2008
..., Hospital Universitario de Canarias, Ofra s/n, La Cuesta, 38320, Tenerife, Spain 2 9 2008 © The Company of Biologists Limited 2008 2008 ATR DNA-damage signalling Cell cycle checkpoints Genome stability Rad9 Proteins involved in signalling DNA damage are critical...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (8): 1483–1493.
Published: 15 April 2006
... in the transcriptional regulation of cyclin B ( Okada et al., 2002 ) and the regulation of S phase and genomic stability ( Beall et al., 2002 ; Manak et al., 2002 ; Beall et al., 2004 ). Interestingly, Dm-Myb appears to have a controlling influence on some processes of endoreplication, that is, cell cycles in which...
Journal Articles
J Cell Sci (2005) 118 (18): 4207–4217.
Published: 15 September 2005
... in Xenopus egg extracts is coupled to initiation of DNA replication. Genes Dev. 16 , 1182 -1194. Zhong, W., Feng, H., Santiago, F. E. and Kipreos, E. T. ( 2003 ). CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing. Nature 423 , 885 -889. Zhu, W., Chen...
Journal Articles
J Cell Sci (2005) 118 (18): 4261–4269.
Published: 15 September 2005
... studies in yeast and human cells have suggested that the members of the RecQ helicase family play a pivotal role in maintaining genome stability ( Hickson, 2003 ). Along with this notion, mutations in the RECQL4 gene have been shown to cause some cases of the Rothmund-Thomson and RAPADILINO syndromes...
Includes: Supplementary data