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Keywords: Gene targeting
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Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2008) 121 (4): 428–436.
Published: 15 February 2008
... assembly WD domain protein Gene targeting Cilia/flagella are present in most eukaryotic organisms, including protozoans and humans, and share a highly organized and conserved microtubule-based structure, the axoneme ( Sleigh, 1974 ). Intraflagellar transport (IFT) is a bi-directional process...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (20): 4322–4331.
Published: 15 October 2006
...-mail: m.peckham@leeds.ac.uk ) 31 7 2006 © The Company of Biologists Limited 2006 2006 Titin Muscle Myofibrillogenesis Gene targeting Titin, the largest protein so far described, is a long, filamentous molecule found in the sarcomeres of skeletal and cardiac muscle that has many...
Journal Articles
Journal Articles
J Cell Sci (2003) 116 (23): 4811–4819.
Published: 1 December 2003
... for initiating or regulating myofibrillogenesis. We used a gene-targeting approach in cultured myoblasts to truncate the titin gene so that the kinase domain and other domains downstream of the kinase were not expressed. We recovered cells in which one allele was targeted. We found that these cells expressed...
Journal Articles
Journal Articles
J Cell Sci (2000) 113 (22): 4077–4086.
Published: 15 November 2000
... normally transported to organelles by AP-3. * Author for correspondence (e-mail: suzi.mansour@genetics.utah.edu ) 31 10 2000 14 09 2000 © 2000 by Company of Biologists 2000 Mouse mutant Gene targeting Hermansky-Pudlak Syndrome Lamp protein Lysosome Melanosome...
Journal Articles
J Cell Sci (1997) 110 (15): 1751–1758.
Published: 1 August 1997
...-mail: gkidder@physiology.uwo.ca ) 17 02 1997 29 05 1997 © 1997 by Company of Biologists 1997 Gap junction Connexin43 Connexin45 Preimplantation development Mouse Intercellular coupling Immunogold labeling Confocal microscopy Gene targeting Gap junctional coupling...
Journal Articles
J Cell Sci (1992) 1992 (Supplement_16): 69–76.
Published: 1 January 1992
... to dissect the molecular mechanisms which transduce the effects of these ligands, both in vivo and in isolated systems. One approach we are employing is gene targeting of retinoic acid receptors (RARs) and cellular retinoid-binding proteins to generate mice in which one or more of these genes has been...
Journal Articles
J Cell Sci (1991) 1991 (Supplement_14): 63–65.
Published: 1 January 1991
...D. J. Manstein; K. M. Ruppel; L. Kubalek; J. A. Spudich ABSTRACT © The Company of Biologists Limited 1991 1991 Dictyostelium discoideum cytoskeleton myosin gene targeting expression The eukaryote Dictyostelium discoideum is an attractive model organism for the study...
Journal Articles
J Cell Sci (1991) 1991 (Supplement_14): 37–40.
Published: 1 January 1991
... genes and gene targeting techniques. Here we review briefly the systems and methods being used in these efforts to dissect protozoan myosin I structure and function using molecular genetic approaches. © The Company of Biologists Limited 1991 1991 myosin I molecular cloning structure-function...