.... Polymorphisms in human non-coding regulatory elements suppress this signaling axis. Inflammation Fibrosis Myocardial regeneration Gene expression Gene regulation Myocardial infarction National Institutes of Health https://doi.org/10.13039/100000002 R01AG045428 S10OD026929 T32GM008666...

..., France. ‡ Author for correspondence ( [email protected] ) Competing interests The authors declare no competing interests. 22 02 2014 18 08 2014 © 2014. Published by The Company of Biologists Ltd 2014 Notch Reck Talin Trio Gene regulation Myogenesis Drosophila...

... furthermore showed that the pronounced tumorigenic effect of GlyR α1 relies on a new intracellular signaling function that depends on the NLS region in the large cytosolic loop and impacts on GL261 glioma cell gene regulation. Stable expression of GlyR α1 and α3 loops rescued the self-renewal capacity of GlyR...

... provided that the original work is properly attributed. Myofibroblast differentiation MKL1 Gene regulation MRTF-A Differentiation of a variety of cell types into myofibroblasts defines a major physiological process that facilitates wound healing and tissue repair. Tissue damage drives...

... ), and bladder ( Chan et al., 2009 ). The characterization of these rare tumorigenic cells has the potential to provide important prognostic and therapeutic value for epithelial cancers. Epithelial–mesenchymal transition Breast cancer stem cells miR-200 DNA methylation Histone modifications Gene...

... and considerable effort to determine the specificity of miRNA-mediated gene regulation at whole-organism levels. miRNAs certainly present a major challenge for the future. Chemically modified oligonucleotides can be used to either inhibit a specific miRNA or to disrupt the binding between an miRNA and its...

... The Company of Biologists Limited 2008 2008 Arginine deiminase Citrullination Sumoylation Antigenic variation Encystation Gene regulation Giardia lamblia is a ubiquitous unicellular parasite of humans and other vertebrates that commonly causes diarrhea and gastrointestinal upset ( Adam...

.... * Author for correspondence (e-mail: [email protected] ) 3 3 2005 © The Company of Biologists Limited 2005 2005 Gene regulation Cell-cell interaction Ciliate pheromones Mating types Sexual maturation Differentiation Conjugation-inducing substances in protozoan...

... and this activity is substantially reduced by profilins, indicating that profilin can regulate p42 POP activity and is therefore involved in gene regulation. Functional association of cytoskeletal proteins other than profilins with transcription factors has also been reported. Nuclear actin has been shown to play...

... for correspondence (e-mail: [email protected] ) 14 11 2000 © 2001 by Company of Biologists 2001 Calcineurin NFAT Gene regulation Changes in intracellular calcium have been implicated in regulating diverse processes in skeletal muscle, including differentiation, hypertrophy, and fiber...

... for a complete structural description of the initial steps in the expression of eukaryotic genes. Transcription initiation Gene regulation Image reconstruction Transcription of eukaryotic genes is a complex process requiring the action of a myriad of proteins. Central to the process is the large...

... electrophysiologically. This could be an important mechanism in gastrointestinal diseases accompanied by barrier defects, for example inflammatory bowel diseases. * Author for correspondence (e-mail: [email protected] ) © 2000 by Company of Biologists 2000 Tight junction Gene regulation...

... like that of untreated control cells. * Author for correspondence 17 02 1993 04 04 1994 © 1994 by Company of Biologists 1994 chemical stress hsp70 synthesis gene regulation heat shock factors Stress response is nearly universal. Living organisms respond...

... in a hepatocellular carcinoma . Nature 343 , 555 – 557 . Wick , M. , Bürger , C. , Brüsselbach , S. , Lucibello , F. C. and Müller , R. ( 1994 ). Identification of serum-inducible genes: different patterns of gene regulation during G0rS and G1rS progression . J. Cell Sci . 107...

... of Biologists 1994 cell cycle cyclin E gene regulation splicing The cyclins represent a major group of cell cycle regulatory proteins present in all eukaryotic cells. They were originally identified as proteins that accumulate during the cell cycle and are degraded in mitosis (for reviews see...

... to 100% for all genes); 1F+8F/AD, 9 hour stimulation with FCS, 8 hour in the presence of actinomycin D. RNAs were analysed by Northern blotting and the data quantitatively evaluated as in Fig. 2 . A relatively unexplored question concerns the differences in gene regulation during the G 0 →S...

... cells. These observations suggest that G 0 →S and G 1 →S transition are distinct processes, exhibiting characteristic programmes of gene regulation, and merging around S-phase entry. * Author for correspondence 19 07 1993 11 11 1993 © 1994 by Company of Biologists 1994...

... ( Matsushime et al., 1991 ; Lew et al., 1991 ; Xiong et al., 1991 ; Koff et al., 1991 ; Motokura et al., 1991 ). cell cycle cyclin D1 growth factors gene regulation signal transduction © 1993 by Company of Biologists 1993 29 09 1992 11 11 1992 * Author...

.... N. & Todaro , G. J. ( 1986 ). Oncostatin M: a growth regulator produced by differentiated histiocytic lymphoma cells . Proc. natn. Acad. Sci. U.S.A . 83 , 9739 – 9743 . © The Company of Biologists Limited 1988 1988 stem cells gene regulation tumour suppression...

... whose occurrence correlates with transcription of the genes modulated by Zraws-acting factors present in expressing versus non-expressing cell hybrids ( Affara et al . 1985 ); they are also close to sequences known to be involved in globin gene regulation (for example, the TATA, CAATand CACCCT motifs...