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Keywords: Gene expression
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Journal Articles
J Cell Sci (2023) 136 (1): jcs259873.
Published: 3 January 2023
... complex is dismantled is essential for appreciating how physiological gene expression is maintained and also how concurrent processes that occur synchronously on the DNA are coordinated. Although the strategies employed by the different classes of eukaryotic RNAPs are traditionally considered...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (19): jcs260082.
Published: 10 October 2022
...) of cancer cells. FOXQ1 may exacerbate cancer by activating the oncogenic Wnt/β-catenin signalling pathway. However, the role of FOXQ1 in the Wnt pathway remains to be resolved. Here, we report that FOXQ1 is an activator of Wnt-induced transcription and regulator of β-catenin target gene expression. Upon Wnt...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2022) 135 (7): jcs259456.
Published: 11 April 2022
... binding to the TSS of genes dependent on Pol II pausing stimulates transcription by promoting Pol II release in a human triple-negative breast cancer cell model. Histone variants RNA polymerase II-paused genes Gene expression Chromatin structure Cellular migration Breast cancer H2020...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (20): jcs254094.
Published: 30 October 2020
... -null cells. Analyses of primary cultures of skin keratinocytes from a mouse strain expressing K17 with a mutated NLS corroborated these findings. Proteomics screens identified K17-interacting nuclear proteins with known roles in gene expression, chromatin organization and RNA processing. Key histone...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (2): jcs214072.
Published: 16 January 2019
... replication. Dbf4 Gcn5 Cell cycle Gene expression Histone acetylation Data availability All raw and supporting data including detailed protocols have been deposited at the Purdue University Research Repository (PURR) as a publically available, archived data set and can be accessed using...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (3): 614–625.
Published: 1 February 2017
... in any medium provided that the original work is properly attributed. Summary: Δ40p53 exerts tumor suppressor activity that is associated with upregulation of p53-target gene expression and induces senescence in hepatocellular carcinoma cell lines. Δ40p53 Gene targeting Liver cancer...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (8): 1649–1660.
Published: 15 April 2016
... but to a lesser extent. Therefore, a complete CWI transcriptional response requires not only phosphorylation of Rlm1 by Slt2 but also concurrent SLT2 - and RLM1 -mediated positive-feedback mechanisms; sustained patterns of gene expression are mainly achieved by positive autoregulatory circuits based...
Journal Articles
J Cell Sci (2014) 127 (7): 1585–1594.
Published: 1 April 2014
... Extracellular vesicle Exosome Gene expression microRNA Cell stress Liver cancer Hypoxia linc-RoR Hepatocellular cancer (HCC) is the fifth most common cancer in men and the seventh most common cancer in women worldwide ( El-Serag, 2012 ). HCC is a highly treatment-resistant malignancy...
Journal Articles
J Cell Sci (2013) 126 (17): 3848–3861.
Published: 1 September 2013
... expressed during differentiation. Table 1. Fifty-three miRNAs induced in the late stage of differentiation and highly expressed in human beta islet cells To identify gene expression changes involved in differentiation of human beta islet cells, genome-wide mRNA expression profiling...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (14): 3055–3069.
Published: 15 July 2013
... periphery has drawn much attention due to its role as a sub-nuclear compartment involved in virulence gene expression. Recent data have implicated components of the nuclear envelope in regulating gene expression in several eukaryotes. Special attention has been given to nucleoporins that compose the nuclear...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (14): 3031–3042.
Published: 15 July 2013
... transcriptional activity is enhanced in the presence of plakoglobin. Our data suggest that plakoglobin regulates gene expression in conjunction with p53 and that plakoglobin may regulate p53 transcriptional activity, which may account, in part, for the tumor/metastasis suppressor activity of plakoglobin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (10): 2294–2304.
Published: 15 May 2013
... glycoprotein gene expression sites, although many members of this diverse family are also transcribed elsewhere in the genome. ESAG9 genes are among the most highly regulated genes in transmissible stumpy forms, encoding a group of secreted proteins of cryptic function. To understand their developmental...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (7): 1682–1691.
Published: 1 April 2013
... for determining gene expression in the differentiating muscle. We have previously shown that PTB protein abundance is progressively reduced during heart development without reduction of its own transcript. Simultaneous reduction of histone deacetylase (HDAC) expression prompted us to investigate the potential...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (5): 1189–1198.
Published: 1 March 2013
... to define their phenotype as slow or fast twitch muscle fibers. We have previously shown that voltage-gated L-type calcium channel (Cav1.1) acts as a voltage sensor for activation of inositol (1,4,5)-trisphosphate [Ins(1,4,5) P 3 ]-dependent Ca 2+ signals that regulates gene expression. ATP released...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (23): 5800–5810.
Published: 1 December 2012
... polarized hepatocyte-like cells (HLCs) from hFHPCs. Global gene expression profiling was performed on triplicate samples of hFHPCs, immature-HLCs and mature-HLCs. When the differential gene expression was compared based on the differentiation stage, a number of genes were identified that might be essential...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (16): 3739–3743.
Published: 15 August 2012
... ( tanabe_hideyuki@soken.ac.jp ; mharata@biochem.tohoku.ac.jp ) 3 4 2012 © 2012. Published by The Company of Biologists Ltd 2012 Actin-related protein Histone variant Nuclear organization Chromosome territory Gene expression Various chromatin remodeling and histone modification...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (9): 2198–2211.
Published: 1 May 2012
...Kanako Watanabe; Yuki Akimoto; Katsuyuki Yugi; Shinsuke Uda; Jaehoon Chung; Shinichi Nakamuta; Kozo Kaibuchi; Shinya Kuroda A latent process involving signal transduction and gene expression is needed as a preparation step for cellular function. We previously found that nerve growth factor (NGF...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (24): 4318–4331.
Published: 15 December 2011
...Laura Leitner; Dmitry Shaposhnikov; Alexander Mengel; Arnaud Descot; Sylvia Julien; Reinhard Hoffmann; Guido Posern Monomeric actin regulates gene expression through serum response factor (SRF) by inhibiting its transcriptional coactivator myocardin-related transcription factor (MAL/MRTF). Many...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (18): 3174–3186.
Published: 15 September 2011
... Scientific Institute, 70013 Castellana Grotte, Bari, Italy 1 6 2011 © 2011. 2011 PC12 cells NT2/D1 cells Neural cell differentiation Neurosecretion Gene expression The RE-1-specific silencing transcription factor (REST, also referred to as NRSF) is a well-known repressor...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (16): 2743–2752.
Published: 15 August 2011
... streamlined efficient replication of the most heavily transcribed genomic loci while simultaneously reducing the risk of chromosome breaks and rDNA hyper-recombination. daniela.dimitrova@bbsrc.ac.uk 26 4 2011 © 2011. 2011 Gene expression Human rRNA genes Nucleolus Replication...
Includes: Supplementary data