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Keywords: Geminin
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Journal Articles
J Cell Sci (2012) 125 (10): 2436–2445.
Published: 15 May 2012
... of the essential licensing factor Cdt1 and inhibition of Cdt1 by geminin. Here we investigate the consequences of ablating geminin in synchronised human U2OS cells. Following geminin loss, cells complete an apparently normal S phase, but a proportion arrest at the G2–M boundary. When Cdt1 accumulates...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2004) 117 (24): 5875–5886.
Published: 15 November 2004
... . We have investigated regulation of the origin licensing factors Cdc6, Cdt1, Mcm2 and Geminin in human somatic and germ cells. Cdc6 and Cdt1 play an essential role in DNA replication initiation by loading the Mcm2-7 complex, which is required for unwinding the DNA helix, onto chromosomal origins...