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Keywords: Gap junction
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Journal Articles
Journal Articles
In collection:
Polarity
J Cell Sci (2024) 137 (5): jcs260924.
Published: 9 November 2023
... controls homeostasis, we investigated the relationship between basoapical polarity and resting MP in three-dimensional culture of the HMT-3522 breast cancer progression. A microelectrode technique to measure MP and input resistance reveals that the MP is raised by gap junction intercellular communication...
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Journal Articles
In collection:
Polarity
J Cell Sci (2019) 132 (10): jcs223313.
Published: 16 May 2019
... to be understood. We demonstrate the involvement of connexin 43 (Cx43, also known as GJA1) and related gap junction in epithelial homeostasis, illustrated by polarity-mediated cell cycle entry and mitotic spindle orientation (MSO). Cx43 localization is restricted to the apicolateral membrane of phenotypically...
Includes: Supplementary data
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Journal Articles
Journal Articles
J Cell Sci (2018) 131 (9): jcs214635.
Published: 4 May 2018
... mutation in Gja1 , encoding Cx43, that is associated with the human-linked disease oculodentodigital dysplasia, leads to severe hearing loss and central auditory defects. Cx43 Connexin Gap junction Hearing loss Noise exposure Canadian Institutes of Health Research 10.13039/501100000024...
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Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2017) 130 (19): 3308–3321.
Published: 1 October 2017
...-conductance gap junction channels (GJChs) and reduced GJCh closed state probability. Substituting alanine at serine residues 275, 302 and 328 eliminated Cx37-induced cell death, supported proliferation and reduced the GJCh closed state probability. With additional alanine for serine substitutions at residues...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2017) 130 (5): 827–840.
Published: 1 March 2017
...Bennett J. Waxse; Prabuddha Sengupta; Geoffrey G. Hesketh; Jennifer Lippincott-Schwartz; Folma Buss ABSTRACT In this study, we demonstrate myosin VI enrichment at Cx43 (also known as GJA1)-containing gap junctions (GJs) in heart tissue, primary cardiomyocytes and cell culture models. In primary...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (3): 531–540.
Published: 1 February 2017
...Megan C. Moorer; Carla Hebert; Ryan E. Tomlinson; Shama R. Iyer; Max Chason; Joseph P. Stains ABSTRACT In skeletal tissue, loss or mutation of the gap junction protein connexin 43 (Cx43, also known as GJA1) in cells of the osteoblast lineage leads to a profound cortical bone phenotype and defective...
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Adhesion
J Cell Sci (2016) 129 (23): 4399–4410.
Published: 1 December 2016
...Srikanth R. Polusani; Edward A. Kalmykov; Anjana Chandrasekhar; Shoshanna N. Zucker; Bruce J. Nicholson ABSTRACT Gap junction proteins (connexins) have crucial effects on cell motility in many systems, from migration of neural crest cells to promotion of metastatic invasiveness. Here, we show...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (21): 3947–3960.
Published: 1 November 2015
... health and hearing. Unexpectedly, Cx30 localization at the cell surface and gap junctional intercellular communication was not affected by prolonged treatments with the endoplasmic reticulum (ER)–Golgi transport inhibitor brefeldin A or the protein synthesis inhibitor cycloheximide, whereas Cx43 (also...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (21): 3888–3897.
Published: 1 November 2015
...Helen Yanran Wang; Ya-Ping Lin; Cheryl K. Mitchell; Sripad Ram; John O'Brien ABSTRACT Gap junctions formed of connexin 36 (Cx36, also known as Gjd2) show tremendous functional plasticity on several time scales. Changes in connexin phosphorylation modify coupling in minutes through an order...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (20): 4343–4350.
Published: 15 October 2014
... by The Company of Biologists Ltd 2014 Aquaporin Gap junction TRP channel There are a number of components of the skin barrier ( Proksch et al., 2008 ). The physical barrier of the skin is formed mainly by the stratum corneum, which consists of dead keratinocytes, or corneocytes...
Journal Articles
Journal Articles
J Cell Sci (2014) 127 (8): 1751–1764.
Published: 15 April 2014
...Amy C. Berger; John J. Kelly; Patrick Lajoie; Qing Shao; Dale W. Laird ABSTRACT Connexin 30 (Cx30), a member of the large gap-junction protein family, plays a role in the homeostasis of the epidermis and inner ear through gap junctional intercellular communication (GJIC). Here, we investigate...
Includes: Supplementary data
Journal Articles