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1-20 of 82
Keywords: Gap junction
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Journal Articles
Stephanie E. Leighton, Robert S. Wong, Sergiu A. Lucaciu, Alexandra Hauser, Danielle Johnston, Peter B. Stathopulos, Donglin Bai, Silvia Penuela, Dale W. Laird
Journal:
Journal of Cell Science
J Cell Sci (2024) 137 (7): jcs261631.
Published: 17 April 2024
...Stephanie E. Leighton; Robert S. Wong; Sergiu A. Lucaciu; Alexandra Hauser; Danielle Johnston; Peter B. Stathopulos; Donglin Bai; Silvia Penuela; Dale W. Laird ABSTRACT Connexins are channel-forming proteins that function to facilitate gap junctional intercellular communication. Here, we use dual...
Includes: Supplementary data
Journal Articles
In collection:
Polarity
Journal:
Journal of Cell Science
J Cell Sci (2024) 137 (5): jcs260924.
Published: 9 November 2023
... controls homeostasis, we investigated the relationship between basoapical polarity and resting MP in three-dimensional culture of the HMT-3522 breast cancer progression. A microelectrode technique to measure MP and input resistance reveals that the MP is raised by gap junction intercellular communication...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2020) 133 (4): jcs235440.
Published: 20 February 2020
...Karyn Jourdeuil; Lisa A. Taneyhill ABSTRACT Gap junctions are intercellular channels between cells that facilitate cell–cell communication. Connexin 43 (Cx43; also known as GJA1), the predominant gap junction protein in vertebrates, is expressed in premigratory cranial neural crest cells...
Includes: Supplementary data
Journal Articles
In collection:
Polarity
D. Bazzoun, H. A. Adissu, L. Wang, A. Urazaev, I. Tenvooren, S. F. Fostok, S. Chittiboyina, J. Sturgis, K. Hodges, G. Chandramouly, P.-A. Vidi, R. S. Talhouk, S. A. Lelièvre
Journal:
Journal of Cell Science
J Cell Sci (2019) 132 (10): jcs223313.
Published: 16 May 2019
... to be understood. We demonstrate the involvement of connexin 43 (Cx43, also known as GJA1) and related gap junction in epithelial homeostasis, illustrated by polarity-mediated cell cycle entry and mitotic spindle orientation (MSO). Cx43 localization is restricted to the apicolateral membrane of phenotypically...
Includes: Supplementary data
Journal Articles
In collection:
Cell biology and disease
Journal:
Journal of Cell Science
J Cell Sci (2019) 132 (2): jcs224097.
Published: 16 January 2019
...John J. Kelly; Julia M. Abitbol; Stephanie Hulme; Eric R. Press; Dale W. Laird; Brian L. Allman ABSTRACT Mutations in the genes that encode the gap junction proteins connexin 26 (Cx26, encoded by GJB2 ) and Cx30 ( GJB6 ) are the leading cause of hereditary hearing loss. That said, the Cx30...
Includes: Supplementary data
Journal Articles
In collection:
Stem cell biology and organoids
Journal:
Journal of Cell Science
J Cell Sci (2018) 131 (13): jcs216135.
Published: 9 July 2018
... as intercellular signals that allow cell–cell communication. Here, the role of the transfer of the microRNA miR-200b between vasculogenic and osteogenic cells was explored in a co-culture system. Rat bone-marrow derived mesenchymal stem cells (BMSCs) formed functional gap junctions composed of connexin 43 (Cx43...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2018) 131 (9): jcs214635.
Published: 4 May 2018
... mutation in Gja1 , encoding Cx43, that is associated with the human-linked disease oculodentodigital dysplasia, leads to severe hearing loss and central auditory defects. Cx43 Connexin Gap junction Hearing loss Noise exposure Canadian Institutes of Health Research 10.13039/501100000024...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2018) 131 (5): jcs207340.
Published: 2 March 2018
...Anuttoma Ray; Parul Katoch; Nimansha Jain; Parmender P. Mehta ABSTRACT Defects in assembly of gap junction-forming proteins, called connexins (Cxs), are observed in a variety of cancers. Connexin32 (Cx32; also known as GJB1) is expressed by the polarized cells in epithelia. We discovered two...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2017) 130 (21): 3619–3630.
Published: 1 November 2017
...), tubular structures connecting close cells or intercellular channels that link the cytoplasm of adjacent cells. In mammals, these different types of communication serve different purposes, may involve distinct factors and are mediated by extracellular vesicles, tunnelling nanotubes or gap junctions. Recent...
Journal Articles
Nicole L. Jacobsen, Tasha K. Pontifex, Hanjun Li, Joell L. Solan, Paul D. Lampe, Paul L. Sorgen, Janis M. Burt
Journal:
Journal of Cell Science
J Cell Sci (2017) 130 (19): 3308–3321.
Published: 1 October 2017
...-conductance gap junction channels (GJChs) and reduced GJCh closed state probability. Substituting alanine at serine residues 275, 302 and 328 eliminated Cx37-induced cell death, supported proliferation and reduced the GJCh closed state probability. With additional alanine for serine substitutions at residues...
Includes: Supplementary data
Journal Articles
Max Z. Totland, Christian H. Bergsland, Tone A. Fykerud, Lars M. Knudsen, Nikoline L. Rasmussen, Peter W. Eide, Zeremariam Yohannes, Vigdis Sørensen, Andreas Brech, Ragnhild A. Lothe, Edward Leithe
Journal:
Journal of Cell Science
J Cell Sci (2017) 130 (17): 2867–2882.
Published: 1 September 2017
...Max Z. Totland; Christian H. Bergsland; Tone A. Fykerud; Lars M. Knudsen; Nikoline L. Rasmussen; Peter W. Eide; Zeremariam Yohannes; Vigdis Sørensen; Andreas Brech; Ragnhild A. Lothe; Edward Leithe ABSTRACT Intercellular communication via gap junctions has an important role in controlling cell...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2017) 130 (5): 827–840.
Published: 1 March 2017
...Bennett J. Waxse; Prabuddha Sengupta; Geoffrey G. Hesketh; Jennifer Lippincott-Schwartz; Folma Buss ABSTRACT In this study, we demonstrate myosin VI enrichment at Cx43 (also known as GJA1)-containing gap junctions (GJs) in heart tissue, primary cardiomyocytes and cell culture models. In primary...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2017) 130 (3): 531–540.
Published: 1 February 2017
...Megan C. Moorer; Carla Hebert; Ryan E. Tomlinson; Shama R. Iyer; Max Chason; Joseph P. Stains ABSTRACT In skeletal tissue, loss or mutation of the gap junction protein connexin 43 (Cx43, also known as GJA1) in cells of the osteoblast lineage leads to a profound cortical bone phenotype and defective...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
Srikanth R. Polusani, Edward A. Kalmykov, Anjana Chandrasekhar, Shoshanna N. Zucker, Bruce J. Nicholson
Journal:
Journal of Cell Science
J Cell Sci (2016) 129 (23): 4399–4410.
Published: 1 December 2016
...Srikanth R. Polusani; Edward A. Kalmykov; Anjana Chandrasekhar; Shoshanna N. Zucker; Bruce J. Nicholson ABSTRACT Gap junction proteins (connexins) have crucial effects on cell motility in many systems, from migration of neural crest cells to promotion of metastatic invasiveness. Here, we show...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2015) 128 (21): 3947–3960.
Published: 1 November 2015
... health and hearing. Unexpectedly, Cx30 localization at the cell surface and gap junctional intercellular communication was not affected by prolonged treatments with the endoplasmic reticulum (ER)–Golgi transport inhibitor brefeldin A or the protein synthesis inhibitor cycloheximide, whereas Cx43 (also...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2015) 128 (21): 3888–3897.
Published: 1 November 2015
...Helen Yanran Wang; Ya-Ping Lin; Cheryl K. Mitchell; Sripad Ram; John O'Brien ABSTRACT Gap junctions formed of connexin 36 (Cx36, also known as Gjd2) show tremendous functional plasticity on several time scales. Changes in connexin phosphorylation modify coupling in minutes through an order...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2014) 127 (20): 4343–4350.
Published: 15 October 2014
... by The Company of Biologists Ltd 2014 Aquaporin Gap junction TRP channel There are a number of components of the skin barrier ( Proksch et al., 2008 ). The physical barrier of the skin is formed mainly by the stratum corneum, which consists of dead keratinocytes, or corneocytes...
Journal Articles
Guillaume Pidoux, Pascale Gerbaud, Jim Dompierre, Birgitte Lygren, Therese Solstad, Danièle Evain-Brion, Kjetil Taskén
Journal:
Journal of Cell Science
J Cell Sci (2014) 127 (19): 4172–4185.
Published: 1 October 2014
... and Cx43 is necessary for discrete control of Cx43 phosphorylation and hCG-stimulated gap junction communication that triggers cell fusion in cytotrophoblasts. Fig. 7. Gap junction communication in trophoblasts is controlled by PKA anchored through Cx43. (A–D) Trophoblasts were transfected...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2014) 127 (8): 1751–1764.
Published: 15 April 2014
...Amy C. Berger; John J. Kelly; Patrick Lajoie; Qing Shao; Dale W. Laird ABSTRACT Connexin 30 (Cx30), a member of the large gap-junction protein family, plays a role in the homeostasis of the epidermis and inner ear through gap junctional intercellular communication (GJIC). Here, we investigate...
Includes: Supplementary data
Journal Articles
Arndt Meyer, Gerrit Hilgen, Birthe Dorgau, Esther M. Sammler, Reto Weiler, Hannah Monyer, Karin Dedek, Sheriar G. Hormuzdi
Journal:
Journal of Cell Science
J Cell Sci (2014) 127 (6): 1190–1202.
Published: 15 March 2014
...Arndt Meyer; Gerrit Hilgen; Birthe Dorgau; Esther M. Sammler; Reto Weiler; Hannah Monyer; Karin Dedek; Sheriar G. Hormuzdi ABSTRACT Electrical synapses (gap junctions) rapidly transmit signals between neurons and are composed of connexins. In neurons, connexin36 (Cx36) is the most abundant isoform...
Includes: Supplementary data
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