...Yu-Ja Huang; Paula Schiapparelli; Kristen Kozielski; Jordan Green; Emily Lavell; Hugo Guerrero-Cazares; Alfredo Quinones-Hinojosa; Peter Searson ABSTRACT Endogenous electric fields modulate many physiological processes by promoting directional migration, a process known as galvanotaxis. Despite...

... mechanism involving the activation of protein phosphatase 2A (PP2A). Here, we ask whether β2-ARs play a role in keratinocyte galvanotaxis. We report a bimodal response. When keratinocytes were exposed to higher concentrations of β-AR agonist (0.1 μM), their tracked migratory speed was inhibited, in both...

...Maria E. Mycielska; Mustafa B. A. Djamgoz Endogenous direct-current electric fields (dcEFs) occur in vivo in the form of epithelial transcellular potentials or neuronal field potentials, and a variety of cells respond to dcEFs in vitro by directional movement. This is termed galvanotaxis...

... Epidermal growth factor receptor Keratinocyte Galvanotaxis The epidermal growth factor receptor (EGFR) is one of the most intensely studied growth factor receptors. Much has been learned about its molecular structure, biological functions and signaling pathways (reviewed in Carpenter, 1987...

... (e-mail: [email protected] ) 02 10 1995 05 03 1996 © 1996 by Company of Biologists 1996 Corneal wound healing Cell migration Corneal epithelium Electric field Galvanotropism Galvanotaxis Serum Growth factor Electric fields (EFs) may play an important role...

... keratinocytes migrating on a collagen substrate while exposed to similar physiological DC electric fields. We find that keratinocytes migrate randomly on collagen in fields of 5 mV/mm or less, but in larger fields they migrate towards the negative pole of the field, exhibiting galvanotaxis. Since these cells...