... , S. W. , Peters , R. , Mandell , M. , Bruun , J. A. , et al. ( 2016 ). TRIMs and galectins globally cooperate and TRIM16 and galectin-3 co-direct autophagy in endomembrane damage homeostasis . Dev. Cell 39 , 13 - 27 . 10.1016/j.devcel.2016.08.003 Cheng , Y. L...

...Ludger Johannes; Ralf Jacob; Hakon Leffler ABSTRACT Galectins are carbohydrate-binding proteins that are involved in many physiological functions, such as inflammation, immune responses, cell migration, autophagy and signalling. They are also linked to diseases such as fibrosis, cancer and heart...

...Sarah E. Stewart; Sam A. Menzies; Stephanie J. Popa; Natalia Savinykh; Anna Petrunkina Harrison; Paul J. Lehner; Kevin Moreau ABSTRACT Galectins are a family of lectin binding proteins expressed both intracellularly and extracellularly. Galectin-3 (Gal-3, also known as LGALS3) is expressed...

...Ivan R. Nabi; Jay Shankar; James W. Dennis ABSTRACT Galectins are a family of widely expressed β-galactoside-binding lectins in metazoans. The 15 mammalian galectins have either one or two conserved carbohydrate recognition domains (CRDs), with galectin-3 being able to pentamerize; they form...

... membrane through a transcytotic pathway mediated by the plus-end kinesin KIF16B. Here, we demonstrate that this apical transcytotic pathway requires apical sorting of basolateral proteins, which is mediated by apical signals and galectin-4. Using RPE and KPT cell lines, and AP-1B-knockdown MDCK cells, we...

... receptor for galectin-1, as both soluble and membrane-associated fragments of CA125 derived from HeLa cell lysates are shown to bind specifically to human galectin-1 with high efficiency. This interaction is demonstrated (1) to depend on β-galactose-terminated, O-linked oligosaccharide chains of CA125, (2...

... demonstrate that galectin-8, a secreted mammalian β -galactoside binding protein, inhibits adhesion of human carcinoma (1299) cells to plates coated with integrin ligands, and induces cell apoptosis. Pretreatment of the cells with Mn 2+ , which increases the affinity of integrins for their ligands, abolished...

...Steffen Goletz; Franz-Georg Hanisch; Uwe Karsten ABSTRACT We report on a novel posttranslational modification of cytoplasmic proteins. Presented evidences suggest that cytokeratins are bound in vitro by mammalian galectin-3 and the galectins from the sponge Geodia cydonium via their type II...

...Bruno Mehul; R. Colin Hughes ABSTRACT Galectin 3, a 30 kDa galactoside-binding protein distributed widely in epithelial and immune cells, contains no signal sequence and is externalized by a mechanism independent of the endoplasmic reticulum (ER)-Golgi complex. We show here that hamster galectin 3...

...Qi Bao; R. Colin Hughes ABSTRACT Galectin-3 is a member of a closely related family of β-galactoside-binding soluble proteins found in many vertebrate epithelial and myeloid cell types. The developmentally regulated presence of galectin-3 in tissues, for example kidney, and an affinity for many...