...–cell adherens junctions to the force-generating actomyosin cytoskeleton. Drosophila Canoe and mammalian afadin play key roles in the regulation of such linkages. One central task for the field is defining mechanisms by which upstream inputs from Ras-family GTPases regulate Canoe and afadin...

... in small GTPases, lipid-anchored proteins and cell signaling proteins. Thus, IFT-A is specialized for the import of membrane-associated proteins. Abnormal levels of the latter are likely to account for the multiple phenotypes of patients with defects in IFT140. This article has an associated First Person...

... for correspondence (e-mail: [email protected]) 12 1 2007 © The Company of Biologists Limited 2007 2007 Rab proteins GTPases Exocytosis Secretion Secretory vesicle Rab proteins comprise the largest group within the Ras superfamily of monomeric GTPases, with 11 Rabs identified...

...Lorena Za; Chiara Albertinazzi; Simona Paris; Mariacristina Gagliani; Carlo Tacchetti; Ivan de Curtis Cell motility entails the reorganization of the cytoskeleton and membrane trafficking for effective protrusion. GIT1/p95-APP1 is a member of a family of GTPase-activating proteins for ARF GTPases...

...Karine Raymond; Evelyne Bergeret; Amélie Avet-Rochex; Ruth Griffin-Shea; Marie-Odile Fauvarque In Drosophila , RotundRacGAP/RacGAP(84C) is critical to retinal organisation and spermatogenesis. We show that eye-directed expression of RacGAP(84C) or its GTPase activating protein (GAP) domain induces...