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Keywords: GTPase
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Journal Articles
In collection:
Metabolism
J Cell Sci (2022) 135 (18): jcs259609.
Published: 14 September 2022
...: This study reveals a noncanonical role of AMP-activated kinase in which the α subunit C-terminal regulatory domain serves as a guanine-nucleotide-exchange factor for Arf6 during glucose deprivation. ADP-ribosylation factor GTPase Glucose deprivation Cell invasion Ministry of Education http...
Includes: Supplementary data
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2021) 134 (7): jcs252411.
Published: 15 April 2021
..., as is the observation that the dominant-negative form of the GTPase is inhibitory when recruited to the plasmalemma constitutively or through heterodimerization. Using current technology it is impossible to unambiguously ascertain that Rab5 + vesicles in fact fuse with the surface membrane before macropinosome...
Includes: Supplementary data
Journal Articles
In collection:
Cell Migration
J Cell Sci (2020) 133 (3): jcs233361.
Published: 4 February 2020
...Kuan-Jung Chen; Tsai-Chen Chiang; Chia-Jung Yu; Fang-Jen S. Lee ABSTRACT Cell migration requires the coordination of multiple signaling pathways involved in membrane dynamics and cytoskeletal rearrangement. The Arf-like small GTPase Arl4A has been shown to modulate actin cytoskeleton remodeling...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (17): jcs216630.
Published: 3 September 2018
...Marita Borg Distefano; Linda Hofstad Haugen; Yan Wang; Harmonie Perdreau-Dahl; Ingrid Kjos; Da Jia; Jens Preben Morth; Jacques Neefjes; Oddmund Bakke; Cinzia Progida ABSTRACT Rab GTPases are key regulators of intracellular trafficking, and cycle between a GTP-bound active state and a GDP-bound...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (4): jcs208199.
Published: 19 April 2018
.... This recruitment requires the HDS1 and HDS2 domains. Golgi Arf GTPase GBF1 Membrane trafficking Regulation The secretory pathway is required for the correct modification and targeting of secretory cargoes. This pathway is composed of a series of membrane-bound compartments with varying...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (10): 1691–1699.
Published: 15 May 2017
...Chia-Jung Yu; Fang-Jen S. Lee ABSTRACT ADP-ribosylation factors (Arfs) and ADP-ribosylation factor-like proteins (Arls) are highly conserved small GTPases that function as main regulators of vesicular trafficking and cytoskeletal reorganization. Arl1, the first identified member of the large Arl...
Journal Articles
In collection:
Mitochondria
J Cell Sci (2016) 129 (11): 2170–2181.
Published: 1 June 2016
... the more prominent role. Using a proximity-based biotin labeling approach, we found close associations between MiD51, Mff and Drp1, but not Fis1. Furthermore, we found that MiD51 can suppress Mff-dependent enhancement of Drp1 GTPase activity. Our data indicates that Mff and MiD51 regulate Drp1 in specific...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (7): 1287–1292.
Published: 1 April 2016
.... , Sasaki , A. T. , Wilkerson , E. M. , Locasale , J. W. , Cantley , L. C. , Kuhlman , B. , Dohlman , H. G. and Campbell , S. L. ( 2013a ). Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function . Nat. Struct. Mol. Biol.   20 , 46 - 52...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (23): 4293–4305.
Published: 1 December 2015
...Bertha C. Elias; Amrita Das; Diptiben V. Parekh; Glenda Mernaugh; Rebecca Adams; Zhufeng Yang; Cord Brakebusch; Ambra Pozzi; Denise K. Marciano; Thomas J. Carroll; Roy Zent ABSTRACT The Rho GTPase Cdc42 regulates key signaling pathways required for multiple cell functions, including maintenance...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (17): 3171–3176.
Published: 1 September 2015
...Yan Zhen; Harald Stenmark ABSTRACT Rab GTPases control intracellular membrane traffic by recruiting specific effector proteins to restricted membranes in a GTP-dependent manner. In this Cell Science at a Glance and the accompanying poster, we highlight the regulation of Rab GTPases by proteins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (14): 2553–2564.
Published: 15 July 2015
...Graham M. Burkart; Tobias I. Baskin; Magdalena Bezanilla ABSTRACT In plants, the ROP family of small GTPases has been implicated in the polarized growth of tip-growing cells, such as root hairs and pollen tubes; however, most of the data derive from overexpressing ROP genes or constitutively active...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (11): 2106–2117.
Published: 1 June 2015
... growth is determined in mid G1. Cdc42 polarization in the first step and its proper positioning depend on Rsr1 and its GTPase-activating protein (GAP) Bud2. Interestingly, Rga1, a Cdc42 GAP, exhibits transient localization to a site near the bud neck and to the division site during cytokinesis and G1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (12): 2615–2620.
Published: 15 June 2014
...Jia-Wei Hsu; Zzu-Jung Chen; Ya-Wen Liu; Fang-Jen S. Lee ABSTRACT Small GTPase ADP-ribosylation factors (ARFs) are key regulators of membrane trafficking and their activities are determined by guanine-nucleotide-binding status. In Saccharomyces cerevisiae , Arl1p, an ARF-like protein, is responsible...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (12): 2647–2658.
Published: 15 June 2014
... vasculature: a dynamic analysis.   Glia   53 , 799 – 808 . 10.1002/glia.20334 Frische   E. W. , Zwartkruis   F. J. ( 2010 ). Rap1, a mercenary among the Ras-like GTPases.   Dev. Biol.   340 , 1 – 9 . 10.1016/j.ydbio.2009.12.043 Hanahan   D. , Weinberg   R. A. ( 2011...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (2): 354–364.
Published: 15 January 2014
... 2013 15 10 2013 © 2014. Published by The Company of Biologists Ltd 2014 Golgi Arf GTPase GBF1 Brefeldin A The Golgi functions as a central organizing organelle in the secretory pathway ( Farquhar and Palade, 1998 ; Emr et al., 2009 ). The central Golgi stack (consisting...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (13): 2773–2784.
Published: 1 July 2013
...Joshua S. Chappie; Fred Dyda Summary Dynamin is a large multidomain GTPase that assembles into helical arrays around the necks of deeply invaginated clathrin-coated pits and catalyzes membrane fission during the final stages of endocytosis. Although it is well established that the function...
Journal Articles
J Cell Sci (2013) 126 (11): 2436–2445.
Published: 1 June 2013
...Ki Lui; Jie An; JoAnne Montalbano; Jingxue Shi; Chad Corcoran; Qin He; Hong Sun; M. Saeed Sheikh; Ying Huang Summary We had previously reported that RBEL1A, a novel Ras-like GTPase, was overexpressed in multiple human malignancies and that its depletion suppressed cell growth. However...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (5): 1059–1069.
Published: 1 March 2013
... clear that autophagy intersects with multiple steps of the endocytic and exocytic pathways, sharing many molecular players. A number of Rab and Arf GTPases that are involved in the regulation of the secretory and the endocytic membrane trafficking pathways, have been shown to play key roles in autophagy...
Journal Articles
J Cell Sci (2012) 125 (19): 4586–4596.
Published: 1 October 2012
... Arl1p and results in less Arl1p residing on the TGN. Biochemically, purified Imh1p competes with Gcs1p, an Arl1p GTPase-activating protein (GAP), for binding to Arl1p, thus interfering with the GAP activity of Gcs1p toward Arl1p. Furthermore, we demonstrate that the self-interaction of Imh1p attenuates...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (14): 3299–3309.
Published: 15 July 2012
...Hamid Tabdili; Adrienne K. Barry; Matthew D. Langer; Yuan-Hung Chien; Quanming Shi; Keng Jin Lee; Shaoying Lu; Deborah E. Leckband Summary This study investigated the impact of cadherin binding differences on both cell sorting and GTPase activation. The use of N-terminal domain point mutants...
Includes: Multimedia, Supplementary data