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Keywords: GSK3
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Journal Articles
J Cell Sci (2018) 131 (10): jcs210575.
Published: 22 May 2018
... of transcriptionally active β-catenin–TCF/Lef complexes. We now demonstrate that XIAP is phosphorylated by GSK3 at threonine 180, and that an alanine mutant (XIAP T180A ) exhibits decreased Wnt activity compared to wild-type XIAP in cultured human cells and in Xenopus embryos. Although XIAP T180A ubiquitylates TLE3...
Includes: Supplementary data
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J Cell Sci (2017) 130 (8): 1404–1412.
Published: 15 April 2017
... understood. In addition to the NDC80 microtubule-binding complex, other proteins with demonstrated microtubule-binding activities localize to kinetochores. One such protein is the cytoplasmic linker-associated protein 2 (CLASP2). Here, we show that global GSK3-mediated phosphorylation of the longest isoform...
Journal Articles
Journal Articles
J Cell Sci (2015) 128 (22): 4235–4245.
Published: 15 November 2015
... 2 (CRMP-2; also known as DPYSL2). An inhibitor of casein kinase 2 (CK2) reduced tubulin binding to the translocation domain, whereas an inhibitor of glycogen synthase kinase 3 (GSK3) facilitated CRMP-2 binding to the translocation domain. Consistently, treatment with the GSK3 inhibitor enhanced...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (18): 3998–4008.
Published: 15 September 2014
... and reprogramming caused by mTOR and Akt inhibitors can be reversed by inhibition of GSK3. Finally, we found that expressing the GSK3β target Esrrb overrides inhibition of Akt and restores reprogramming. Our data demonstrated that during reprogramming, Akt promotes establishment of pluripotency through co...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (21): 3537–3544.
Published: 1 November 2011
...Ciara Metcalfe; Mariann Bienz The key read-out of Wnt signalling is a change in the transcriptional profile of the cell, which is driven by β-catenin. β-catenin levels are normally kept low by a phosphorylation event that is mediated by glycogen synthase kinase 3 (GSK3, α- and β-isoforms), which...
Journal Articles
Journal Articles
J Cell Sci (2008) 121 (22): 3717–3728.
Published: 15 November 2008
... branches in cultured hippocampal neurons, indicative that ATP exerts a negative influence on axonal growth. These data suggest that P2X7 antagonists have therapeutic potential to promote axonal regeneration. P2X7 Brilliant Blue G Axonal growth Axonal branching CaMKII FAK GSK3 The formation...
Includes: Supplementary data