... glycosylphosphatidylinositol (GPI)-anchored proteins and thereby promotes neuronal differentiation both in vitro and in vivo . GDE2 is a prognostic marker in neuroblastoma, while loss of GDE2 leads to progressive neurodegeneration in mice; however, its regulation remains unclear. Here, we report that, in immature neuronal...

... ). Our findings add an additional group of substrates for this important E3 ligase, namely pre-inserted GPI-anchored proteins. It appears that Doa10 reacts to the cytosolic presence of the hydrophobic GPI-anchoring sequence because both various substrates bearing a GPI-anchoring sequence and the isolated...

... enzyme is a GPI-anchored protein releasing factor crucial for fertilization . Nat. Med. 11 , 160 - 166 . Kondoh G. , Watanabe H. , Tashima Y. , Maeda Y. , Kinoshita T. ( 2009 ). Testicular angiotensin-converting enzyme with different glycan modification...

... for the intracellular trafficking of vesicles generated by dynamin-independent endocytic pathways. * These authors contributed equally to this work ‡ Author for correspondence ( [email protected] ) 12 8 2010 © 2010. 2010 GPI-anchored protein PI3K Dynamin Endocytosis...

...Ya-Wen Liu; Szu-Wei Lee; Fang-Jen S. Lee The molecular mechanisms involved in the transport of GPI-anchored proteins from the trans-Golgi network (TGN) to the cell periphery have not been established. Arl1p is a member of the Arf-like protein (Arl) subfamily of small GTPases and is localized...

... the females after mating are unfertilized. In in vitro assays, the knockout eggs are severely deficient in their ability to fuse with sperm. These results demonstrate that GPI-anchored proteins are required for gamete fusion. Loss of the GPI-anchored complement of plasma membrane proteins could prevent fusion...

... protein( Food et al., 1994 ) and,because MTf does not have a cytoplasmic domain, the effect of ConA might be mediated by the binding of a ConA-MTf complex to a transmembrane receptor. One GPI-anchored protein [CD14, which binds to lipopolysaccharide (LPS)] forms a complex with a transmembrane Toll-like...