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Keywords: GPCR
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Journal Articles
J Cell Sci (2021) 134 (16): jcs255455.
Published: 17 August 2021
...Alper D. Ozkan; Tina Gettas; Audrey Sogata; Wynn Phaychanpheng; Miou Zhou; Jérôme J. Lacroix ABSTRACT G-protein-coupled receptor (GPCR) 68 (GPR68, or OGR1) couples extracellular acidifications and mechanical stimuli to G-protein signaling and plays important roles in vascular physiology...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (5): jcs254268.
Published: 25 January 2021
... characterization of the viral and cellular factors involved in their upstream regulation remains elusive. Herein, we show the HCMV-encoded G protein-coupled receptor (GPCR), UL33 , is expressed during latency. Although this viral GPCR is not required to maintain latent infection, our data reveal UL33-mediated...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2019) 132 (16): jcs230334.
Published: 23 August 2019
... Borroto-Escuela , D. O. , Carlsson , J. , Ambrogini , P. , Narváez , M. , Wydra , K. , Tarakanov , A. O. , Li , X. , Millón , C. , Ferraro , L. , Cuppini , R. , et al. ( 2017 ). Understanding the Role of GPCR Heteroreceptor Complexes in Modulating the Brain...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (2): jcs224428.
Published: 16 January 2019
... in the organelle. Certain G-protein-coupled receptors (GPCRs) specifically localize to the membrane compartment of primary cilia. To gain insight into the mechanisms that regulate ciliary GPCR sorting, we investigated the atypical small GTPase RAB-like 2 (RABL2; herein referring to the near-identical human...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (15): jcs218016.
Published: 01 August 2018
...Shuang Li; Yong Suk Cho; Bing Wang; Shuangxi Li; Jin Jiang ABSTRACT Hedgehog (Hh) transduces signals by promoting cell surface accumulation and activation of the G-protein-coupled receptor (GPCR)-family protein Smoothened (Smo) in Drosophila , but the molecular mechanism underlying the regulation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (11): jcs212910.
Published: 05 June 2018
... pathways are likely to be linked. Our goal was to show that Opn4 possesses distinct heterotrimer activation abilities compared with other G q -coupled GPCRs. Gα q GTP generated upon G q -coupled GPCR (including Opn4) activation stimulates PLCβ, which hydrolyzes the plasma membrane (PM) phospholipid...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (22): 3907–3917.
Published: 15 November 2017
... are, therefore, crucial in shaping neuronal activity and function, depending on their individual temporal and spatial properties. Furthermore, many neurotransmitters and drugs that act through G protein coupled receptors (GPCRs), modulate neuronal activity by altering the expression, trafficking, or function...
Journal Articles
J Cell Sci (2017) 130 (9): 1532–1544.
Published: 01 May 2017
...: Multiple Wnts are co-expressed in various physiological and disease states. We show that coexpression of specific Wnt ligands synergistically activates β-catenin signaling with biological consequences. GPCR Wnt signaling Cancer Development Synergy Wnts are secreted morphogens that control...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (2): 490–501.
Published: 15 January 2017
...Mònica Pons; Ismael Izquierdo; Mireia Andreu-Carbó; Georgina Garrido; Jesús Planagumà; Olivia Muriel; Miguel A. del Pozo; M. Isabel Geli; Anna M. Aragay ABSTRACT Proper endosomal trafficking of ligand-activated G-protein-coupled receptors (GPCRs) is essential to spatiotemporally tune...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2016) 129 (11): 2156–2169.
Published: 01 June 2016
..., by interacting with specific protein ligands (in trans and/or in cis) on the cell surface and/or extracellular matrix (ECM). Unlike other GPCRs, adhesion GPCRs are characterized by an extended extracellular domain (ECD) upstream of the seven transmembrane (7TM) segment ( Hamann et al., 2015 ; Stacey et al...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (19): 3533–3542.
Published: 01 October 2015
...Caitlin D. Hanlon; Deborah J. Andrew ABSTRACT G-protein-coupled receptors (GPCRs) are the largest family of receptors in many organisms, including worms, mice and humans. GPCRs are seven-transmembrane pass proteins that are activated by binding a stimulus (or ligand) in the extracellular space...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (6): 1230–1240.
Published: 15 March 2015
... by demonstrating that the actin motor and filopodial cargo carrier protein myosin X (Myo10) and the G-protein-coupled receptor (GPCR) signaling effector β-arrestin-2 (Arrb2) transit into cytonemes. This work delineates a biological function for Lgr4 and Lgr5 and provides the rationale to fully investigate Lgr4...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (1): 118–128.
Published: 01 January 2015
.... 9 06 2014 29 10 2014 © 2015. Published by The Company of Biologists Ltd 2015 EFR3 GPCR Receptor desensitization Angiotensin II PI 4-kinase Phosphoinositide A selected group of G-protein-coupled receptors (GPCRs) activate phospholipase C (PLC) by coupling...
Journal Articles
J Cell Sci (2014) 127 (7): 1359–1367.
Published: 01 April 2014
...Loredana Puca; Christel Brou ABSTRACT For many years, β-arrestins have been known to be involved in G-protein-coupled receptor (GPCR) desensitization. However, β-arrestins belong to a family of proteins that act as multifunctional scaffolding proteins, in particular during trafficking...
Journal Articles
J Cell Sci (2014) 127 (1): 111–123.
Published: 01 January 2014
...   D. , Rutherford   R. B. ( 1990 ). Interleukin-1 regulation of procollagenase mRNA and protein in periodontal fibroblasts in vitro.   J. Periodontal Res.   25 , 222 – 229 . 10.1111/j.1600-0765.1990.tb00908.x Ritter   S. L. , Hall   R. A. ( 2009 ). Fine-tuning of GPCR activity...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (20): 4614–4626.
Published: 15 October 2013
...Joseph A. Brzostowski; Satoshi Sawai; Orr Rozov; Xin-hua Liao; Daisuke Imoto; Carole A. Parent; Alan R. Kimmel Summary Migratory cells, including mammalian leukocytes and Dictyostelium , use G-protein-coupled receptor (GPCR) signaling to regulate MAPK/ERK, PI3K, TORC2/AKT, adenylyl cyclase...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (19): 4507–4517.
Published: 01 October 2012
... 2012 NFκB A 2B adenosine receptor p105 Inflammation GPCR Extracellular adenosine elicits a wide array of physiological and pathological responses via binding to its four subtypes of cell surface receptors A 1 , A 2A , A 2B and A 3 , each of which has a unique pharmacological profile...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (19): 3292–3304.
Published: 01 October 2011
...-associated variants of WDR36 affected its ability to modulate Gαq-mediated signalling by TPβ. We report that WDR36 acts as a new scaffold protein tethering a G-protein-coupled receptor, Gαq and PLCβ in a signalling complex. G-protein-coupled receptors (GPCRs) are the largest family of membrane receptors...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (24): 4259–4270.
Published: 15 December 2010
.... 2010 β-arrestins GPCR GRK ERK δ-opioid receptor Serine 363 phosphorylation Opioid receptors belong to the superfamily of G-protein-coupled receptors (GPCRs), which couple to the Gi/o proteins. Like many other GPCRs, opioid receptors undergo internalization and desensitization...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (24): 4465–4472.
Published: 15 December 2009
... in the ER, suggesting that the quality control system of this compartment did not permit further traffic of folding-defective polypeptides through the secretory system ( Kaushal and Khorana, 1994 ; Sung et al., 1991 ). Rhodopsin is an archetypal seven-transmembrane G-protein-coupled receptor (GPCR...
Includes: Supplementary data