...Sergei Chavez-Abiega; Max L. B. Grönloh; Theodorus W. J. Gadella, Jr; Frank J. Bruggeman; Joachim Goedhart ABSTRACT Kinases play key roles in signaling networks that are activated by G-protein-coupled receptors (GPCRs). Kinase activities are generally inferred from cell lysates, hiding cell-to-cell...

...Alper D. Ozkan; Tina Gettas; Audrey Sogata; Wynn Phaychanpheng; Miou Zhou; Jérôme J. Lacroix ABSTRACT G-protein-coupled receptor (GPCR) 68 (GPR68, or OGR1) couples extracellular acidifications and mechanical stimuli to G-protein signaling and plays important roles in vascular physiology...

... characterization of the viral and cellular factors involved in their upstream regulation remains elusive. Herein, we show the HCMV-encoded G protein-coupled receptor (GPCR), UL33 , is expressed during latency. Although this viral GPCR is not required to maintain latent infection, our data reveal UL33-mediated...

.../ Highlighted Article: A FRET-based method is used to assess the impact of GPCR hetero-oligomerization on downstream signaling and contributes to the identification of the stoichiometry of endogenously expressed GPCRs under physiological conditions. G protein-coupled receptor GPCR 5-HT 7 R 5-HT 1A R...

... in the organelle. Certain G-protein-coupled receptors (GPCRs) specifically localize to the membrane compartment of primary cilia. To gain insight into the mechanisms that regulate ciliary GPCR sorting, we investigated the atypical small GTPase RAB-like 2 (RABL2; herein referring to the near-identical human...

...Shuang Li; Yong Suk Cho; Bing Wang; Shuangxi Li; Jin Jiang ABSTRACT Hedgehog (Hh) transduces signals by promoting cell surface accumulation and activation of the G-protein-coupled receptor (GPCR)-family protein Smoothened (Smo) in Drosophila , but the molecular mechanism underlying the regulation...

.... , Zhang , Y. , et al. ( 2016 ). Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling . Proc. Natl. Acad. Sci. USA   113 , 1937 - 1942 . 10.1073/pnas.1523645113 Masseck , O. A. , Spoida , K. , Dalkara , D. , Maejima , T. , Rubelowski...

... are, therefore, crucial in shaping neuronal activity and function, depending on their individual temporal and spatial properties. Furthermore, many neurotransmitters and drugs that act through G protein coupled receptors (GPCRs), modulate neuronal activity by altering the expression, trafficking, or function...

...: Multiple Wnts are co-expressed in various physiological and disease states. We show that coexpression of specific Wnt ligands synergistically activates β-catenin signaling with biological consequences. GPCR Wnt signaling Cancer Development Synergy National Research Foundation Singapore...

...Mònica Pons; Ismael Izquierdo; Mireia Andreu-Carbó; Georgina Garrido; Jesús Planagumà; Olivia Muriel; Miguel A. del Pozo; M. Isabel Geli; Anna M. Aragay ABSTRACT Proper endosomal trafficking of ligand-activated G-protein-coupled receptors (GPCRs) is essential to spatiotemporally tune...

... 2016 © 2016. Published by The Company of Biologists Ltd 2016 Summary: GPR56 is an adhesion GPCR that we show interacts with heparin through heparin-interacting motifs. This interaction regulates cell adhesion, which has possible implications for diseases such as cancer. Adhesion...

...Caitlin D. Hanlon; Deborah J. Andrew ABSTRACT G-protein-coupled receptors (GPCRs) are the largest family of receptors in many organisms, including worms, mice and humans. GPCRs are seven-transmembrane pass proteins that are activated by binding a stimulus (or ligand) in the extracellular space...

... by demonstrating that the actin motor and filopodial cargo carrier protein myosin X (Myo10) and the G-protein-coupled receptor (GPCR) signaling effector β-arrestin-2 (Arrb2) transit into cytonemes. This work delineates a biological function for Lgr4 and Lgr5 and provides the rationale to fully investigate Lgr4...

... eukaryotes. * Author for correspondence ( [email protected] ) Competing interests The authors declare no competing interests. 9 06 2014 29 10 2014 © 2015. Published by The Company of Biologists Ltd 2015 EFR3 GPCR Receptor desensitization Angiotensin II PI 4-kinase...

...Loredana Puca; Christel Brou ABSTRACT For many years, β-arrestins have been known to be involved in G-protein-coupled receptor (GPCR) desensitization. However, β-arrestins belong to a family of proteins that act as multifunctional scaffolding proteins, in particular during trafficking...

... GTPase. * Author for correspondence ( [email protected] ) Competing interests The authors declare no competing interests. 12 04 2013 12 10 2013 © 2014. Published by The Company of Biologists Ltd 2014 GPCR G-protein-coupled receptor Rab Trafficking...

...Joseph A. Brzostowski; Satoshi Sawai; Orr Rozov; Xin-hua Liao; Daisuke Imoto; Carole A. Parent; Alan R. Kimmel Summary Migratory cells, including mammalian leukocytes and Dictyostelium , use G-protein-coupled receptor (GPCR) signaling to regulate MAPK/ERK, PI3K, TORC2/AKT, adenylyl cyclase...

... Inflammation GPCR Extracellular adenosine elicits a wide array of physiological and pathological responses via binding to its four subtypes of cell surface receptors A 1 , A 2A , A 2B and A 3 , each of which has a unique pharmacological profile, tissue distribution and effector coupling. Adenosine...

... © 2011. 2011 WDR36 Thromboxane A 2 GPCR G protein Phospholipase C G-protein-coupled receptors (GPCRs) are the largest family of membrane receptors responsible for mediating extracellular to intracellular signalling. They respond to a variety of stimuli, including light, hormones...

.... 2010 β-arrestins GPCR GRK ERK δ-opioid receptor Serine 363 phosphorylation Opioid receptors belong to the superfamily of G-protein-coupled receptors (GPCRs), which couple to the Gi/o proteins. Like many other GPCRs, opioid receptors undergo internalization and desensitization...