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Keywords: GPCR
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Journal Articles
In collection:
Imaging
J Cell Sci (2022) 135 (6): jcs259685.
Published: 11 March 2022
...Sergei Chavez-Abiega; Max L. B. Grönloh; Theodorus W. J. Gadella, Jr; Frank J. Bruggeman; Joachim Goedhart ABSTRACT Kinases play key roles in signaling networks that are activated by G-protein-coupled receptors (GPCRs). Kinase activities are generally inferred from cell lysates, hiding cell-to-cell...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (16): jcs255455.
Published: 17 August 2021
...Alper D. Ozkan; Tina Gettas; Audrey Sogata; Wynn Phaychanpheng; Miou Zhou; Jérôme J. Lacroix ABSTRACT G-protein-coupled receptor (GPCR) 68 (GPR68, or OGR1) couples extracellular acidifications and mechanical stimuli to G-protein signaling and plays important roles in vascular physiology...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (5): jcs254268.
Published: 25 January 2021
... characterization of the viral and cellular factors involved in their upstream regulation remains elusive. Herein, we show the HCMV-encoded G protein-coupled receptor (GPCR), UL33 , is expressed during latency. Although this viral GPCR is not required to maintain latent infection, our data reveal UL33-mediated...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2019) 132 (16): jcs230334.
Published: 23 August 2019
... ratio of serotonin receptors in immature and mature neurons may be critically involved in both the onset and response to treatments of psychiatric diseases, such as anxiety and depression. While the concept of GPCR oligomerization has moved from a hypothesis to a well-accepted phenomenon...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (2): jcs224428.
Published: 16 January 2019
... in the organelle. Certain G-protein-coupled receptors (GPCRs) specifically localize to the membrane compartment of primary cilia. To gain insight into the mechanisms that regulate ciliary GPCR sorting, we investigated the atypical small GTPase RAB-like 2 (RABL2; herein referring to the near-identical human...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (15): jcs218016.
Published: 1 August 2018
...Shuang Li; Yong Suk Cho; Bing Wang; Shuangxi Li; Jin Jiang ABSTRACT Hedgehog (Hh) transduces signals by promoting cell surface accumulation and activation of the G-protein-coupled receptor (GPCR)-family protein Smoothened (Smo) in Drosophila , but the molecular mechanism underlying the regulation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (11): jcs212910.
Published: 5 June 2018
...: In addition to its canonical pathway, the photoreceptor melanopsin (Opn4) signals through G proteins βγ and α i and controls several major signaling pathways, which may explain its multi-functionality. Melanopsin Opn4 Retinal GPCR G protein Signal transduction Opsin Non-mammalian...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (22): 3907–3917.
Published: 15 November 2017
... are, therefore, crucial in shaping neuronal activity and function, depending on their individual temporal and spatial properties. Furthermore, many neurotransmitters and drugs that act through G protein coupled receptors (GPCRs), modulate neuronal activity by altering the expression, trafficking, or function...
Journal Articles
J Cell Sci (2017) 130 (9): 1532–1544.
Published: 1 May 2017
...: Multiple Wnts are co-expressed in various physiological and disease states. We show that coexpression of specific Wnt ligands synergistically activates β-catenin signaling with biological consequences. GPCR Wnt signaling Cancer Development Synergy Wnts are secreted morphogens that control...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (2): 490–501.
Published: 15 January 2017
...Mònica Pons; Ismael Izquierdo; Mireia Andreu-Carbó; Georgina Garrido; Jesús Planagumà; Olivia Muriel; Miguel A. del Pozo; M. Isabel Geli; Anna M. Aragay ABSTRACT Proper endosomal trafficking of ligand-activated G-protein-coupled receptors (GPCRs) is essential to spatiotemporally tune...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2016) 129 (11): 2156–2169.
Published: 1 June 2016
... 2016 © 2016. Published by The Company of Biologists Ltd 2016 Summary: GPR56 is an adhesion GPCR that we show interacts with heparin through heparin-interacting motifs. This interaction regulates cell adhesion, which has possible implications for diseases such as cancer. Adhesion...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (19): 3533–3542.
Published: 1 October 2015
...Caitlin D. Hanlon; Deborah J. Andrew ABSTRACT G-protein-coupled receptors (GPCRs) are the largest family of receptors in many organisms, including worms, mice and humans. GPCRs are seven-transmembrane pass proteins that are activated by binding a stimulus (or ligand) in the extracellular space...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (6): 1230–1240.
Published: 15 March 2015
... by demonstrating that the actin motor and filopodial cargo carrier protein myosin X (Myo10) and the G-protein-coupled receptor (GPCR) signaling effector β-arrestin-2 (Arrb2) transit into cytonemes. This work delineates a biological function for Lgr4 and Lgr5 and provides the rationale to fully investigate Lgr4...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (1): 118–128.
Published: 1 January 2015
... unrecognized player in determining AT1 receptor and, possibly, other GPCR responsiveness. Cells possess several protective mechanisms to prevent excessive stimulation of their GPCRs. High concentrations of GPCR ligand often lead to rapid receptor desensitization that diminishes the ability of the receptor...
Journal Articles
J Cell Sci (2014) 127 (7): 1359–1367.
Published: 1 April 2014
...Loredana Puca; Christel Brou ABSTRACT For many years, β-arrestins have been known to be involved in G-protein-coupled receptor (GPCR) desensitization. However, β-arrestins belong to a family of proteins that act as multifunctional scaffolding proteins, in particular during trafficking...
Journal Articles
J Cell Sci (2014) 127 (1): 111–123.
Published: 1 January 2014
...   R. A. ( 2009 ). Fine-tuning of GPCR activity by receptor-interacting proteins.   Nat. Rev. Mol. Cell Biol.   10 , 819 – 830 . 10.1038/nrm2803 Rosa   J. L. , Casaroli-Marano   R. P. , Buckler   A. J. , Vilaró   S. , Barbacid   M. ( 1996 ). p619, a giant protein related...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (20): 4614–4626.
Published: 15 October 2013
...Joseph A. Brzostowski; Satoshi Sawai; Orr Rozov; Xin-hua Liao; Daisuke Imoto; Carole A. Parent; Alan R. Kimmel Summary Migratory cells, including mammalian leukocytes and Dictyostelium , use G-protein-coupled receptor (GPCR) signaling to regulate MAPK/ERK, PI3K, TORC2/AKT, adenylyl cyclase...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (19): 4507–4517.
Published: 1 October 2012
... levels of p105 in the control cells prior to A 2B AR overexpression. Alternatively, the overexpression of A 2B AR activates the receptors without agonists, as it is well known that the overexpression of GPCRs without agonist stimulation mimics agonist-dependent activation of the receptors ( Milano et al...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (19): 3292–3304.
Published: 1 October 2011
...@USherbrooke.ca ) WDR36 Thromboxane A 2 GPCR G protein Phospholipase C G-protein-coupled receptors (GPCRs) are the largest family of membrane receptors responsible for mediating extracellular to intracellular signalling. They respond to a variety of stimuli, including light, hormones...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (24): 4259–4270.
Published: 15 December 2010
.... 2010 β-arrestins GPCR GRK ERK δ-opioid receptor Serine 363 phosphorylation Opioid receptors belong to the superfamily of G-protein-coupled receptors (GPCRs), which couple to the Gi/o proteins. Like many other GPCRs, opioid receptors undergo internalization and desensitization...
Includes: Supplementary data