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Keywords: GLUT4
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J Cell Sci (2017) 130 (2): 396–405.
Published: 15 January 2017
...Lan Gao; Junling Chen; Jing Gao; Hongda Wang; Wenyong Xiong ABSTRACT GLUT4 (also known as SLC2A4) is essential for glucose uptake in skeletal muscles and adipocytes, which play central roles in whole-body glucose metabolism. Here, using direct stochastic optical reconstruction microscopy (dSTORM...
Includes: Supplementary data
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J Cell Sci (2016) 129 (11): 2273–2284.
Published: 1 June 2016
...Maya Talantikite; Marion Berenguer; Teresa Gonzalez; Marie Christine Alessi; Marjorie Poggi; Franck Peiretti; Roland Govers ABSTRACT Glucose transporter GLUT4 (also known as SLC2A4) plays a major role in glucose homeostasis and is efficiently retained intracellularly in adipocytes and myocytes...
Includes: Supplementary data
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J Cell Sci (2013) 126 (9): 1931–1941.
Published: 1 May 2013
... (GLUT4) from intracellular compartments to the cell surface. Rab GTPases regulate the trafficking itinerary of GLUT4 and several have been found on immunopurified GLUT4 vesicles. Specifically, Rab14 has previously been implicated in GLUT4 trafficking in muscle although its role, if any, in adipocytes...
Includes: Supplementary data
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J Cell Sci (2008) 121 (20): 3413–3421.
Published: 15 October 2008
...: SNAP-25 and VAMP2. Depletion of endogenous CENPF disrupts GLUT4 trafficking whereas expression of a dominant-negative form of CENPF inhibits cell coupling. Taken together, these studies demonstrate that CENPF provides a direct link between proteins of the SNARE system and the microtubule network...
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J Cell Sci (2007) 120 (23): 4197–4208.
Published: 1 December 2007
...Gavin I. Welsh; Sophie E. Leney; Bethan Lloyd-Lewis; Matthew Wherlock; Andrew J. Lindsay; Mary W. McCaffrey; Jeremy M. Tavaré The translocation of GLUT4 to the plasma membrane underlies the ability of insulin to stimulate glucose uptake, an event that involves the activation of protein kinase B...
Includes: Supplementary data
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J Cell Sci (2002) 115 (14): 2857–2866.
Published: 15 July 2002
...Pierre-Henri Ducluzeau; Laura M. Fletcher; Gavin I. Welsh; Jeremy M. Tavaré We have investigated the role of protein kinase B (Akt) in the insulin-stimulated translocation of vesicles containing the insulin-responsive isoform of glucose transporter (GLUT4) to the plasma membrane of adipocytes...
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J Cell Sci (2000) 113 (22): 4065–4076.
Published: 15 November 2000
...Michael A. Lampson; Attila Racz; Samuel W. Cushman; Timothy E. McGraw ABSTRACT Insulin-responsive trafficking of the GLUT4 glucose transporter and the insulin-regulated aminopeptidase (IRAP) in adipose and muscle cells is well established. Insulin regulation of GLUT4 trafficking in these cells...
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J Cell Sci (1999) 112 (24): 4793–4800.
Published: 15 December 1999
...Alison K. Gillingham; Françoise Koumanov; Paul R. Pryor; Barbara J. Reaves; Geoffrey D. Holman ABSTRACT Nycodenz gradients have been used to examine the in vitro effects of GTP-γ-S on adaptor complex association with GLUT4 vesicles. On addition of GTP-γ-S, GLUT4 fractionates as a heavier population...