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Keywords: GGA
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Journal Articles
J Cell Sci (2012) 125 (3): 634–648.
Published: 1 February 2012
... to interact directly with the ear domain of γ-adaptin of Drosophila AP-1, but not with the GAE domain of Drosophila GGA. In S2 cells, Drosophila Aftiphilin and AP-1 formed a complex and colocalized at the Golgi compartment. Moreover, tissue-specific depletion of AP-1 or Aftiphilin in the developing eyes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (3): 460–471.
Published: 1 February 2010
... that a clathrin adaptor Drosophila GGA (dGGA), a homolog of mammalian GGA proteins, localizes to the trans -Golgi network (TGN) and is capable of recruiting clathrin from the cytosol onto TGN membranes. dGGA itself is recruited from the cytosol to the TGN in an ARF1 small GTPase (dARF79F)-dependent manner. dGGA...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (8): 1243–1251.
Published: 15 April 2008
..., we show that the internalized IRAP-AA 76,77 construct is sequestered in an IRC that is insensitive to brefeldin A yet sensitive to a dominant-interfering mutant of AS160 (AS160-4P). In addition, we show that the GGA clathrin adaptors are not required for the re-entry of IRAP from the cell surface...
Journal Articles
J Cell Sci (2004) 117 (22): 5437–5445.
Published: 15 October 2004
...). Because most BACE activity occurs in endosomes, signals regulating its trafficking to these compartments are important to an understanding of AD pathogenesis. A DISLL sequence near the BACE C-terminus mediates binding of BACE to the VHS domains of Golgi-localized γ-ear-containing ARF-binding (GGA...
Journal Articles
J Cell Sci (2001) 114 (19): 3413–3418.
Published: 1 October 2001
...Annette L. Boman The GGA proteins are a novel family of proteins that were discovered nearly simultaneously by several labs studying very different aspects of membrane trafficking. Since then, several studies have described the GGA proteins and their functions in yeast and mammalian cells. Four...