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Keywords: GEF
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Membrane trafficking
J Cell Sci (2023) 136 (6): jcs260522.
Published: 8 March 2023
... formation, Rab22A must be activated by a specific guanine-nucleotide-exchange factor (GEF); however, all of the GEFs that have been reported to exhibit Rab22A-GEF activity in vitro also activate Rab5A, an essential regulator of the clathrin-mediated endocytosis pathway, and no Rab22A-specific GEF has ever...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (13): jcs247080.
Published: 9 July 2020
... endosomes initially contain Rab5, which is replaced by Rab7 on late endosomes prior to their fusion with lysosomes. Recruitment of Rab7 to endosomes requires the Mon1–Ccz1 guanine-nucleotide-exchange factor (GEF). Here, we show that full function of the Drosophila Mon1–Ccz1 complex requires a third...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (10): jcs241141.
Published: 27 May 2020
... place across the Golgi. GEF Golgi RAB GTPase Exocytosis Multisubunit tethering complex Ministerio de Ciencia, Innovación y Universidades  BIO2015-65090R RTI2018-093344-B-I00 Comunidad de Madrid 10.13039/100012818 S2017/BMD-3691 InGEMICS-CM Transport protein...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (23): jcs236018.
Published: 3 December 2019
...Brian S. Hercyk; Julie Rich-Robinson; Ahmad S. Mitoubsi; Marcus A. Harrell; Maitreyi E. Das ABSTRACT Cdc42, a conserved regulator of cell polarity, is activated by two GEFs, Gef1 and Scd1, in fission yeast. Why the cell needs two GEFs is unclear, given that they are partially redundant and activate...
Includes: Supplementary data
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Imaging
J Cell Sci (2018) 131 (1): jcs210419.
Published: 8 January 2018
..., distribution and reproduction in any medium provided that the original work is properly attributed. Summary: The development of a fluorescent reporter of GTPase activation based on tripartite split-GFP that enables the evaluation of GEF activity and the effect of modulators of GTPase activation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (10): 1691–1699.
Published: 15 May 2017
... trafficking GEF GAP Ministry of Science and Technology 10.13039/100007225 MOST-103-2320-B-002-048-MY3 CMRPD3E0081-3 The ADP-ribosylation factors (Arfs) are members of a small GTPase family within the Ras superfamily that regulate membrane transport, organelle integrity, membrane lipid...
Journal Articles
In collection:
Imaging
J Cell Sci (2016) 129 (4): 729–742.
Published: 15 February 2016
... and function. Ras signaling GEF GRF1 GRF2 Retina Cone photoreceptor Nuclear migration Intracellular traffic The RASGRF family of mammalian guanine nucleotide exchange factors (GEFs) has two highly homologous members, GRF1 and GRF2 (also known as RASGRF1 and RASGRF2...
Journal Articles
J Cell Sci (2016) 129 (2): 329–340.
Published: 15 January 2016
... Highlighted Article: A combination of a Rab7 sensor and confocal FRET imaging techniques revealed that the Mon1–Ccz1 complex activates Rab7 only on late endosome and dissociates from lysosome in mammalian cells. Small GTPase FRET Endolysosomal pathway GEF Endocytosis and endolysosomal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (16): 3041–3054.
Published: 15 August 2015
...-GTPases is spatio-temporally controlled at endothelial adherens junctions by guanine-nucleotide exchange factors (GEFs) is incompletely understood. Here, we identify a crucial role for the Rho-GEF Trio in stabilizing junctions based around vascular endothelial (VE)-cadherin (also known as CDH5). Trio...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (21): 5074–5085.
Published: 1 November 2013
...Nichol L. G. Miller; Christine Lawson; Elizabeth G. Kleinschmidt; Isabelle Tancioni; Sean Uryu; David D. Schlaepfer Summary Rgnef (also known as p190RhoGEF or ARHGEF28) is a Rho guanine-nucleotide-exchange factor (GEF) that binds focal adhesion kinase (FAK). FAK is recruited to adhesions...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (20): 3478–3489.
Published: 15 October 2010
... in Gas1p transport, cell wall integrity or vacuolar structure. These findings reveal that activation of Arl1p is regulated in part by Syt1p, and imply that Arl1p activation, by using more than one GEF, exerts distinct biological activities at the Golgi compartment. * These authors contributed...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (6): 1093–1103.
Published: 15 March 2007
... protein (CPEB) is required for polyadenylation-induced translation of mRNAs encoding cell cycle regulators. Xenopus Gef (XGef), a Rho-family guanine-exchange factor, influences the activating phosphorylation of CPEB. An exchange-deficient version of XGef does not, therefore implicating Rho-family GTPase...
Journal Articles
Journal Articles
J Cell Sci (2004) 117 (8): 1291–1300.
Published: 15 March 2004
... Polarisation Rho GTPases GEF PAR proteins Polarity touches on essentially every aspect of cell and developmental biology. Cell polarity is of fundamental importance for proliferation, differentiation and morphogenesis; yet, despite these diverse contexts, its broad features, such as the ability...
Journal Articles
J Cell Sci (2004) 117 (2): 155–161.
Published: 15 January 2004
..., PIKE-L, resides in multiple intracellular compartments. Nerve growth factor treatment leads to PIKE-S activation by triggering the nuclear translocation of phospholipase C (PLC)-γ1, which acts as a physiological guanine nucleotide exchange factor (GEF) for PIKE-S through its Src-homlogy 3 (SH3) domain...
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J Cell Sci (2000) 113 (11): 1883–1889.
Published: 1 June 2000
... it is well established that the Sec7 domain functions as a guanine nucleotide exchange factor (GEF) for ADP-ribosylation factors (ARFs) and the PH domain anchors the proteins to membrane phosphoinositols, the function of the N-terminal domain is unknown. Here we show that the N terminus of B2-1 (residues 1...
Journal Articles
J Cell Sci (2000) 113 (4): 729–739.
Published: 15 February 2000
...A. Blangy; E. Vignal; S. Schmidt; A. Debant; C. Gauthier-Rouvière; P. Fort ABSTRACT Rho GTPases regulate the morphology of cells stimulated by extracellular ligands. Their activation is controlled by guanine exchange factors (GEF) that catalyze their binding to GTP. The multidomain Trio protein...