... cycle. In this organism, gene expression is partially controlled through epigenetic mechanisms, the regulation of which is, hence, of paramount importance to the parasite. The P. falciparum (Pf)-GCN5 histone acetyltransferase (HAT), an essential enzyme, acetylates histone 3 and regulates global gene...

...Eliana F. Torres-Zelada; Robert E. Stephenson; Aktan Alpsoy; Benjamin D. Anderson; Selene K. Swanson; Laurence Florens; Emily C. Dykhuizen; Michael P. Washburn; Vikki M. Weake ABSTRACT Metazoans contain two homologs of the Gcn5-binding protein Ada2, Ada2a and Ada2b, which nucleate formation...

... locus, induces large-scale chromatin decondensation, predominantly during G1 phase of the cell cycle. Orc5 associates with the H3 histone acetyl transferase GCN5 (also known as KAT2A), and this association enhances the chromatin-opening function of Orc5. In the absence of Orc5, histone H3 acetylation...

... Histone acetylation Histone phosphorylation ATAC JIL-1 SU(VAR)3-9 GCN5 ADA2 Post-translational modifications of the N-terminal tails of nucleosomal core histones provide important means of regulating chromatin structure and processes that involve chromatin in eukaryotic cells. The different...