... an interaction with a G protein pathway complex (GPC) comprising Gα i/o , GAP-43 and G protein regulated inducer of neurite outgrowth 1 (Gprin1) in differentiating cells. Morphological studies indicate that α7 receptors regulate neurite length and complexity via a Gprin1-dependent mechanism that directs...

... ). Hence, there must be intracellular proteins which control nerve cell shape, so-called ‘plasticity’ or ‘growth’ genes. GAP-43 may be such a molecule ( Skene and Willard, 1981 ; Benowitz and Lewis, 1983 ). For example, GAP-43 is localized to the growth cone membrane ( Meiri et al . 1986 ; Skene et al...