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Keywords: GAP
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Journal Articles
J Cell Sci (2020) 133 (3): jcs238865.
Published: 10 February 2020
... and cardiofaciocutaneous syndromes are all driven by excessive RAS–ERK signaling ( Roberts et al., 2006 ). Just as GTP loading is tightly regulated in normal tissue, the GTPase activity of RAS is under the control of a family of regulatory proteins called GTPase-activating proteins (GAPs). Although GTPase activity...
Journal Articles
J Cell Sci (2018) 131 (17): jcs216630.
Published: 3 September 2018
... inactive state. This cycle is regulated by guanine-nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Several efforts have been made in connecting the correct GEFs and GAPs to their specific Rab. Here, we aimed to identify GAPs for Rab7b, the small GTPase involved in transport from...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (14): 2382–2393.
Published: 15 July 2017
... dynamics. In an earlier phosphotyrosine proteomics study, we identified a novel Rho-GTPase activating protein, now known as ARHGAP42, as a likely biologically relevant Src substrate. ARHGAP42 is a member of a family of RhoGAPs distinguished by tandem BAR-PH domains lying N-terminal to the GAP domain. Like...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (10): 1691–1699.
Published: 15 May 2017
... trafficking GEF GAP The ADP-ribosylation factors (Arfs) are members of a small GTPase family within the Ras superfamily that regulate membrane transport, organelle integrity, membrane lipid modifications, cytoskeletal dynamics and signal transduction ( Boman and Kahn, 1995 ; Gillingham and Munro...
Journal Articles
J Cell Sci (2007) 120 (15): 2683–2693.
Published: 1 August 2007
...Carlene D. Moore; Erin E. Thacker; Jennifer Larimore; David Gaston; Alison Underwood; Brian Kearns; Sean I. Patterson; Trevor Jackson; Chris Chapleau; Lucas Pozzo-Miller; Anne Theibert Centaurin α1 is an Arf GTPase-activating protein (GAP) that is highly expressed in the nervous system...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2005) 118 (20): 4689–4700.
Published: 15 October 2005
... downregulation is p190, a ubiquitously expressed GTPase activating protein (GAP). We show that, in p190-deficient fibroblasts, the typical functional activities mediated by plexins (such as cell collapse and inhibition of integrin-based adhesion) are blocked or greatly impaired. Notably, the functional response...
Includes: Supplementary data
Journal Articles
J Cell Sci (2000) 113 (9): 1611–1621.
Published: 1 May 2000
.... To this end we isolated and characterized the A. gossypii homolog of the Saccharomyces cerevisiae BEM2 gene which is part of a network of rho-GTPases and their regulators required for bud emergence and bud growth in yeast. Here we show that the AgBem2 protein contains a GAP-(GTPase activating protein) domain...
Journal Articles
J Cell Sci (1999) 112 (2): 231–242.
Published: 15 January 1999
...Joan M. Taylor; Marlene M. Macklem; J. Thomas Parsons ABSTRACT Graf, the GTPase regulator associated with focal adhesion kinase was previously shown to have GAP activity for Rho A and Cdc42 in vitro ( Hildebrand et al 1996 Mol. Cell Biol. 16: 3169-3178). In this study we sought to determine whether...
Journal Articles
J Cell Sci (1998) 111 (7): 941–950.
Published: 1 April 1998
... which, like other calmodulin-containing myosins, exhibits maximal velocity of actin filaments (15 nm/second) in the absence of Ca 2+ . Native myosin-IXb exhibits GAP activity on rho. Class IX myosins may be an important link between rho and rho-dependent remodeling of the actin cytoskeleton...
Journal Articles
J Cell Sci (1996) 109 (3): 653–661.
Published: 1 March 1996
... domain of protein kinase C and a putative GTPase-activating protein (GAP) domain of the rho/rac family of ras-like G-proteins. Northern blot analysis of 16 different human tissues revealed an ∼8 kb transcript that is most highly expressed in peripheral blood leukocytes, with somewhat lower levels...