... lines, ATG4B knockout reduced proliferation, abolished processing of LC3B (also known as MAP1LC3B), and reduced GABARAP and GABARAPL1 levels, but increased ATG4A levels. ATG4B and ATG4A double knockout lines displayed a further reduction in proliferation, characterized by delays in G1-S phase transition...

... interaction and functions, and are reviewed here. Autophagy ATG8 LC3 GABARAP Post-translational modifications Phosphorylation Fundación Ramon Areces National Institutes of Health http://dx.doi.org/10.13039/100000002 K99AG062774 R01AG038664 R01AG07279 P01AG031862...

... work is properly attributed. Summary: The role of the core ATG8 system during autophagosome formation and autophagosome-lysosome fusion. ATG8 Autophagosome Autophagy GABARAP LC3 National Health and Medical Research Council http://dx.doi.org/10.13039/501100000925...

... and biogenesis. In higher eukaryotes, the Atg8 family comprises six members known as the light chain 3 (LC3) or γ-aminobutyric acid (GABA)-receptor-associated protein (GABARAP) proteins. Considerable effort during the last 15 years to decipher the molecular mechanisms that govern autophagy has significantly...

... ( [email protected] ) © 2013. Published by The Company of Biologists Ltd 2013 ATG8 LC3 GABARAP LIR p62 Selective autophagy Macroautophagy (hereafter referred to as autophagy) is an intracellular degradation process, in which a double membrane structure called the phagophore expands...