... and hydrogen peroxide induce phosphorylation of eIF2α, a known Gcn2 target, and an arrest in G1 phase. By contrast, exposure to psoralen plus long-wavelength ultraviolet light, inducing DNA adducts and crosslinks, or to ionizing radiation induce neither eIF2α phosphorylation nor a cell-cycle delay. We conclude...

... in the levels of p21 or p27, the Cdk inhibitors that are often targeted by extracellular signals in G1 phase ( Fig. 3C ). Moreover, ERK activity was not affected by knock-down of E-cadherin ( Fig. 3C ), indicating that cadherin induction of cyclin D1 operated through a distinct signaling pathway. Fig. 3...

... 2007 Actin cytoskeleton Cell cycle progression Cell spreading Cyclin D G1 phase Integrin signaling G1 phase progression of nontransformed adherent cells depends both on the presence of growth factors and adhesion to the extracellular matrix (ECM). Growth factor-stimulated adherent...

... AKAP149 is a novel PP1-specifying subunit involved in maintaining nuclear architecture through G1 phase. PP1 remains associated with NE-bound AKAP149 during G1 but is released from AKAP149 upon S phase entry, as AKAP149 becomes serine-phosphorylated. NE-associated AKAP149 inhibits PP1 activity towards...

... damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation. EMBO J. 17 , 2687 -2698. Donjerkovic, D. and Scott, D. W. ( 2000 ). Regulation of the G1 phase of the mammalian cell cycle. Cell Res. 10 , 1 -16. Durocher, D. and Jackson, S. P. ( 2001...

... – 376 . 10.1242/jcs.75.1.357 Moreno , S. and Nurse , P. ( 1994 ). Regulation of progression through the G1 phase of the cell cycle by the rum1+ gene . Nature 367 , 236 – 242 . 10.1038/367236a0 Nishi , K. , Shimoda , C. and Hayashibe , M. ( 1978...