...Richard J. McDowell; Jessica Rodgers; Nina Milosavljevic; Robert J. Lucas ABSTRACT Melanopsin is an opsin photopigment and light-activated G-protein-coupled receptor; it is expressed in photoreceptive retinal ganglion cells (mRGCs) and can be employed as an optogenetic tool. Mammalian melanopsins...

...: Superior activation of G protein-coupled receptor signaling by a viral chemokine might lead to novel ideas for fine-tuning immune responses and improve control of infection. Chemokines Cytomegalovirus Dendritic cells G-protein-coupled receptor Immune evasion XCL1 XCR1 Deutsche...

... to enable successful conjugation in S. pombe . Fission yeast Mating pheromone G-protein-coupled receptor Autocrine Sexual agglutination Cell fusion Sexual reproduction accelerates evolution by increasing the diversity of the gene pool. The fission yeast Schizosaccharomyces pombe has...

...Bhagawat C. Subramanian; Konstadinos Moissoglu; Carole A. Parent ABSTRACT Neutrophils sense and respond to diverse chemotactic cues through G-protein-coupled receptors (GPCRs). However, the precise trafficking dynamics of chemoattractant GPCRs during neutrophil activation and chemotaxis remain...

...Véronik Lachance; Jade Degrandmaison; Sébastien Marois; Mélanie Robitaille; Samuel Génier; Stéphanie Nadeau; Stéphane Angers; Jean-Luc Parent ABSTRACT We and others have shown that trafficking of G-protein-coupled receptors is regulated by Rab GTPases. Cargo-mediated regulation of vesicular...

...Freek van Hemert; Milena D. Lazova; B. Ewa Snaar-Jagaska; Thomas Schmidt The interaction of G-protein-coupled receptors with G proteins is a key event in transmembrane signal transduction that leads to vital decision-making by the cell. Here, we applied single-molecule epifluorescence microscopy...

... a shuttling of the G protein subunits between the cytoplasm and the membrane. It is therefore very feasible that the dynamic process of G protein coupling to the G protein-coupled receptor could be affected by downstream signalling components. This is currently tested in D. discoideum. Certainly, in order...

...Ryan J. Hoefen; Bradford C. Berk The G-protein-coupled receptor (GPCR)-kinase-interacting proteins 1 and 2 (GIT1 and GIT2) are ubiquitous multidomain proteins involved in diverse cellular processes. They traffic between three distinct cellular compartments (cytoplasmic complexes, focal adhesions...

... by a G-protein-coupled receptor (GPCR). Orphan GPCRs with homology to peptide receptors were screened for HA interaction. Electrophysiological recordings in frog oocytes and in mammalian cell lines as well as Ca 2+ mobilisation assays revealed nanomolar affinities of HA to GPR37. HA signal transduction...

... and desensitization of the lysophosphatidic acid receptor LPA1. Biochem. J. 385 , 677 -684. Barak, L. S., Ferguson, S. S., Zhang, J. and Caron, M. G. ( 1997 ). A beta-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation. J. Biol. Chem. 272 , 27497 -27500...

...Junhyong Kim; John R. Carlson A new algorithm that examines DNA databases for proteins that have a particular structure, as opposed to a particular sequence, represents a novel`e-genetics' approach to gene discovery. The algorithm has successfully identified new G-protein-coupled receptors, which...

...Louis M. Luttrell; Robert J. Lefkowitz β-arrestins are versatile adapter proteins that form complexes with most G-protein-coupled receptors (GPCRs) following agonist binding and phosphorylation of receptors by G-protein-coupled receptor kinases (GRKs). They play a central role in the interrelated...