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Keywords: Fusion pore
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Journal Articles
J Cell Sci (2014) 127 (24): 5218–5227.
Published: 15 December 2014
...Kathrin Neuland; Neeti Sharma; Manfred Frick ABSTRACT Ca 2+ -dependent regulation of fusion pore dilation and closure is a key mechanism determining the output of cellular secretion. We have recently described ‘fusion-activated’ Ca 2+ entry (FACE) following exocytosis of lamellar bodies in alveolar...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (18): 4271–4282.
Published: 15 September 2005
... fusion, respectively. We further show that in up to 70% of the cases exocytosis does not result in significant release of the peptide cargo, likely because of a mechanism that leads to premature closure of the fusion pore. Release of nucleotides and protons occurred regardless of whether peptides were...
Journal Articles
J Cell Sci (2003) 116 (23): 4751–4762.
Published: 1 December 2003
... Freeze-fracture Fusion pore Vacuolar H + -ATPases (V-ATPases) translocate protons across the membrane of various organelles (lysosomes, endosomes, trans-Golgi cisternae, secretory granules etc.), creating an electrochemical proton gradient that is acidic and positive within these intracellular...
Journal Articles
J Cell Sci (2003) 116 (2): 273–283.
Published: 15 January 2003
... in the localized exocytosis. In the present report, scanning electron microscopy revealed collections of pits or craters, up to ∼1.5 μm in diameter. These pits are evidently fusion pores at sites of recent exocytosis, clustered in the immediate vicinity of the deepening furrow base and therefore near the furrow...
Includes: Multimedia, Supplementary data