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Keywords: Fusion
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Journal Articles
In collection:
Mitochondria
J Cell Sci (2021) 134 (24): jcs258944.
Published: 15 December 2021
... it is established that impairments in mitochondrial fusion and fission impact the mitochondrial genome and can lead to mtDNA depletion, abnormal nucleoid organization or accumulation of deletions, it is not entirely clear how or why remodeling mitochondrial network morphology affects mtDNA. Here, we focus on recent...
Journal Articles
J Cell Sci (2019) 132 (4): jcs218321.
Published: 10 August 2018
... unilamellar vesicles and infectious X-31 influenza virus, and testing for the newly identified pore intermediate of membrane fusion, we observed ∼30–87% poration, depending upon lipid composition. Testing the hypothesis that spontaneous curvature (SC) of the lipid monolayer controls membrane poration, our...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (10): jcs213587.
Published: 21 May 2018
..., this leads to various physiological defects, including embryonic lethality, neurodegeneration and overt inflammation. The reasons for such drastic lysosome enlargement remain unclear. Here, we examined whether biosynthesis and/or fusion-fission dynamics contribute to swelling. First, we show that PIKfyve...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (11): 1877–1889.
Published: 1 June 2017
...Swati Arora; Ingrid Saarloos; Robbelien Kooistra; Rhea van de Bospoort; Matthijs Verhage; Ruud F. Toonen ABSTRACT Neuronal dense-core vesicles (DCVs) transport and secrete neuropeptides necessary for development, plasticity and survival, but little is known about their fusion mechanism. We show...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
J Cell Sci (2017) 130 (7): 1209–1216.
Published: 1 April 2017
... membrane (phagophore), formation and maturation of the autophagosome and, finally, fusion with a late endosome or lysosome. Although there are significant insights into each of these steps, the mechanisms of autophagosome–lysosome fusion are least understood, although there have been several recent...
Journal Articles
J Cell Sci (2012) 125 (24): 5937–5943.
Published: 15 December 2012
...Jin Xu; Kimberly A. Toops; Fernando Diaz; Jose Maria Carvajal-Gonzalez; Diego Gravotta; Francesca Mazzoni; Ryan Schreiner; Enrique Rodriguez-Boulan; Aparna Lakkaraju Summary Fusion of lysosomes with the plasma membrane is a calcium-dependent process that is crucial for membrane repair, limiting...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (7): 1683–1692.
Published: 1 April 2012
...Surya Karunakaran; Terry Sasser; Sailasree Rajalekshmi; Rutilio A. Fratti Homotypic vacuole fusion requires SNAREs, the Rab Ypt7p, the tethering complex HOPS, regulatory lipids and actin. In Saccharomyces cerevisiae , actin functions at two stages of vacuole fusion. Pre-existing actin filaments...
Journal Articles
J Cell Sci (2011) 124 (7): 1126–1135.
Published: 1 April 2011
...Fabian Anton; Julia M. Fres; Astrid Schauss; Benoît Pinson; Gerrit J. K. Praefcke; Thomas Langer; Mafalda Escobar-Henriques Dynamin-related GTPase proteins (DRPs) are main players in membrane remodelling. Conserved DRPs called mitofusins (Mfn1/Mfn2/Fzo1) mediate the fusion of mitochondrial outer...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (19): 3266–3275.
Published: 1 October 2010
... of the gene leads to aberrant vacuolar morphology and defective vacuolar protein sorting. These phenotypes are hallmarks of malfunctioning vacuole homeostasis and indicate that membrane fusion is probably altered. Here, we investigated the role of Nhx1p in the regulation of homotypic vacuole fusion. Vacuoles...
Journal Articles
J Cell Sci (2010) 123 (18): 3052–3060.
Published: 15 September 2010
... differentiate and undergo cell–cell fusion to form regenerating myofibers. Myogenic progenitor cells must be precisely regulated and positioned for proper cell fusion to occur. Chemokines are secreted proteins that share both leukocyte chemoattractant and cytokine-like behavior and affect the physiology...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (15): 2533–2542.
Published: 1 August 2010
... dynamics, which is described as the balance between mitochondrial fusion and fission, has revealed that functional and structural alterations in mitochondrial morphology are important factors in several key pathologies associated with aging. Indeed, a recent wave of studies has demonstrated the pleiotropic...
Journal Articles
J Cell Sci (2009) 122 (19): 3542–3553.
Published: 1 October 2009
.... The V-ATPase V 0 subunit is thought to have a separate role in budding and fusion events. Prolonged treatment of professional secretory cells with selective V-ATPase inhibitors (bafilomycin A1, concanamycin A) was used to investigate its role in secretory-granule biogenesis. As expected...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (7): 1045–1053.
Published: 1 April 2009
...Jason H. Pomerantz; Semanti Mukherjee; Adam T. Palermo; Helen M. Blau Fusion of mammalian cells to form stable, non-dividing heterokaryons results in nuclear reprogramming without the exchange of genetic material. In this report, we show that reprogramming in somatic cell heterokaryons involves...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (4): 670–681.
Published: 15 February 2007
... a model of IGF-1-induced hypertrophy of human myotubes, in which hypertrophy was not only characterized by an increase in myotube size and myosin content but also by an increased recruitment of reserve cells for fusion. Here, we describe a new mechanism of IGF-1-induced hypertrophy by demonstrating...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (17): 3561–3570.
Published: 1 September 2006
... from triangular to bipolar when they form groups of aligned cells. Antisense oligonucleotide knockdown of non-muscle myosin 2A, but not non-muscle myosin 2B, inhibited this shape change, interfered with cell-cell adhesion, had a minor effect on tail retraction and prevented myoblast fusion. By contrast...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (11): 2173–2183.
Published: 1 June 2006
... 18 4 2006 © The Company of Biologists Limited 2006 2006 ER-exit sites ER-to-Golgi transport ERGIC-53 Protein sorting COPI COPII Tethering Fusion The ER-Golgi intermediate compartment (ERGIC) is a complex membrane system between the rough endoplasmic reticulum (ER...
Journal Articles
J Cell Sci (2005) 118 (20): 4701–4708.
Published: 15 October 2005
...Anna McNeil; Paul L. McNeil Homotypic fusion among echinoderm egg yolk granules has previously been reconstituted in vitro, and shown to be a rapid, Ca 2+ -triggered reaction that can produce extremely large (>10 μm diameter) fusion products. We here show that, prior to Ca 2+ -triggered fusion...
Journal Articles
J Cell Sci (2005) 118 (6): 1209–1222.
Published: 15 March 2005
...@imcb.a-star.edu.sg ) 18 1 2005 © The Company of Biologists Limited 2005 2005 Tethering complex TRAPP SNARE Bet3 ER Golgi Vesicle Fusion Intracellular protein transport (in either anterograde or retrograde direction) between different compartments of the secretory...
Journal Articles
J Cell Sci (2004) 117 (11): 2345–2356.
Published: 1 May 2004
...Tim Whalley; Kim Timmers; Jens Coorssen; Ludmila Bezrukov; David H. Kingsley; Joshua Zimmerberg The role of cytosolic ATPases such as N-ethylmaleimide (NEM)-sensitive fusion protein (NSF) in membrane fusion is controversial. We examined the physiology and biochemistry of ATP and NSF in the cortical...
Journal Articles
J Cell Sci (2003) 116 (13): 2763–2774.
Published: 1 July 2003
...Ansgar Santel; Stephan Frank; Brigitte Gaume; Michael Herrler; Richard J. Youle; Margaret T. Fuller Mitochondrial fusion may regulate mitochondrial morphogenesis and underlie complementation between mitochondrial genomes in mammalian cells. The nuclear encoded mitochondrial proteins Mfn1 and Mfn2...