...Pei Zhi Cheryl Chia; Isabelle Gasnereau; Zi Zhao Lieu; Paul A. Gleeson The endopeptidase furin and the trans -Golgi network protein TGN38 are membrane proteins that recycle between the TGN and plasma membrane. TGN38 is transported by a retromer-dependent pathway from early endosomes to the TGN...

.... The upstream role of PCs in the control of many physiological and pathological processes generates a growing interest in understanding their regulation. Here, we demonstrate that the serine protease inhibitor plasminogen activator inhibitor 1 (PAI-1) forms an SDS-stable complex with the PC furin, which leads...

...Jinbo Han; Yiguo Wang; Suming Wang; Chengwu Chi Furin is a proprotein convertase that cycles between the plasma membrane, endosomes and the trans-Golgi network (TGN), maintaining a predominant distribution in the latter. Mint3, a member of the Mint protein family, is involved in the signaling...

... to this work 13 4 2005 © The Company of Biologists Limited 2005 2005 Autotaxin NPP2 Lysophospholipase D Furin Signal peptide Autotaxin, also known as NPP2 (nucleotide pyrophosphatase/phosphodiesterase 2) and hereafter referred to as NPP2] is a protein of 103 kDa...

...Gaétan Mayer; Guy Boileau; Moïse Bendayan Matrix metalloproteinases (MMPs) and integrins are essential for cell and extracellular matrix homeostasis. Both membrane type-1 MMP (MT1-MMP) and the integrin αV subunit are fully activated upon cleavage at a furin recognition site. Furin is shuttled...

... of Biologists 2001 Peptide processing Furin Protein trafficking Protein phosphatase 2A Many bioactive peptides and proteins are produced from larger precursors by proteolytic processing at sites containing basic amino acids. A number of endopeptidases that cleave proteins at basic amino acids...

... approach. Processing of carboxy-terminal fibrillin-1 was strongly influenced by N-glycosylation at the site immediately downstream of the furin site, and by association with calreticulin. The carboxy terminus of fibrillin-2 underwent less efficient processing than carboxy-terminal fibrillin-1 under...

...-6-phosphate receptors (M6PRs) in the recruitment of AP-1 to ISGs. M6PRs were detected in ISGs isolated from PC12 cells by subcellular fractionation, and by immuno-EM labelling on cryosections. In light of our previous results, where greater than 80% of the ISGs were found to contain furin, we...