...Kristine Bjerve Gützkow; Soheil Naderi; Heidi K. Blomhoff Increased intracellular levels of cAMP, induced by forskolin, lead to permanent G1 arrest of Reh cells. As expected, we observed a rapid dephosphorylation of the retinoblastoma protein (pRB) within 2 hours of forskolin treatment concomitant...

.... ( 1989 ). Gelsolin modulation in epithelial and stromal cells of mammary carcinoma . Am. J. Pathol . 134 , 597 – 603 . Chew , C. S. ( 1983 ). Forskolin stimulation of acid and pepsinogen secretion in isolated gastric glands . Amer. J. Physiol . 245 , C371 – C380 . 10.1152/ajpcell...

... of proteins and their correct sorting towards the cell surface. In the present work we have explored the possibility that post-translational events may interfere with this process by investigating the short term effects of a potent adenylyl cyclase activator, forskolin, on cell surface expression...

... of a polarized monolayer covered by an apical brush border that express several hydrolases. The adaptation of these cells to grow in the continuous presence of forskolin, a drug known to stimulate adenylyl cyclase permanently, has been previously shown to result in a decreased apical expression of hydrolases...