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Keywords: Formin
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Journal Articles
J Cell Sci jcs.258973.
Published: 11 October 2021
...Anja Schmidt; Long Li; Zhiyi Lv; Shuling Yan; Jörg Großhans Rho signaling with its major targets the formin Dia, Rho kinase (Rok) and non-muscle myosin II control turnover, amount and contractility of actomyosin. Much less investigated has been a potential function for the distribution of F-actin...
Journal Articles
J Cell Sci (2020) 133 (3): jcs233791.
Published: 12 February 2020
...Peter van Gisbergen; Shu-Zon Wu; Xiaohang Cheng; Kelli A. Pattavina; Magdalena Bezanilla ABSTRACT Formins are actin regulators critical for diverse processes across eukaryotes. With many formins in plants and animals, it has been challenging to determine formin function in vivo . We found...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (13): jcs227447.
Published: 01 July 2019
... show that increasing ergosterol levels in the plasma membrane blocks the assembly of F-actin cables from cytokinetic precursor nodes, preventing their compaction into a ring. Abnormal F-actin cables form after a delay, leading to randomly placed septa. Since the formin Cdc12 was detected on cytokinetic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (15): 2506–2519.
Published: 01 August 2017
.... However, despite the relatively large number of proteins implicated in actin−microtubule crosstalk, the mechanisms whereby actin polymerization is coupled to microtubule stabilization and advancement in the peripheral growth cone remained largely unclear. Here, we identified the formin Dishevelled...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (10): 1730–1739.
Published: 15 May 2017
...Matthew R. Miller; Eric W. Miller; Scott D. Blystone ABSTRACT Having previously located the formin FMNL1 in macrophage podosomes, we developed an in vivo model to assess the role of FMNL1 in the migration activities of primary macrophages. Deletion of FMNL1 in mice was genetically lethal; however...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (6): 1085–1091.
Published: 15 March 2016
... barbed-end-interacting proteins and the kinetic mechanisms by which they regulate actin filament assembly. We take F-actin capping protein, gelsolin, profilin and barbed-end-tracking polymerases, including formins and WH2-domain-containing proteins, as examples, and illustrate how their activity...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (8): 1796–1805.
Published: 15 April 2013
... of lateral and basal domains as well as suppression of tubular extensions in the basal domain. The actin nucleator mediating this function is unknown. We found that the formin Diaphanous (Dia) is required for establishing and maintaining distinct lateral and basal domains during cellularization. In dia...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (11): 2765–2774.
Published: 01 June 2012
... completely. Simultaneous imaging of the vesicle membrane and the actin coat revealed that contraction of the actin coat compresses the vesicle following fusion. This leads to active extrusion of vesicle contents. Initial actin coating of fused vesicles is dependent on activation of Rho and formin-dependent...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2012) 125 (6): 1420–1428.
Published: 15 March 2012
... into parallel arrays directed at the growing tip. In other systems, similar microtubule alignments are mediated by the formin family of cytoskeletal regulators. We screened a library of human formins and indentified formin-like 3 (FMNL3; also known as FRL2) as a crucial regulator of EC elongation during...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (9): 1533–1541.
Published: 01 May 2011
... dynamics. Actin cables in yeast are formin-generated linear actin arrays that serve as tracks for directed intracellular transport by type V myosins. Cables are constantly reorganized throughout the cell cycle but the molecular basis for such dynamics remains poorly understood. By combining total internal...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (4): 589–599.
Published: 15 February 2011
... mRNA to the perinuclear region, providing a new way to manipulate intracellular mRNA localization. Formin Diaphanous Translation GTPase Cytoskeleton FRET Actin Although ongoing translation is important for tethering the mRNAs encoding for secreted and membrane proteins on the ER...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (8): 1247–1252.
Published: 15 April 2010
... downstream partner in stress-fiber formation – the Diaphanous-related formin mDia1. Rif-induced stress fibers also depend on the activity of the ROCK protein kinase. Unlike RhoA, Rif does not raise ROCK activity in cells, instead Rif appears to regulate the localization of myosin light chain phosphorylation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (9): 1430–1440.
Published: 01 May 2009
...Ekta Seth Chhabra; Vinay Ramabhadran; Scott A. Gerber; Henry N. Higgs In addition to its ability to accelerate filament assembly, which is common to formins, INF2 is a formin protein with the unique biochemical ability to accelerate actin filament depolymerization. The depolymerization activity...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (20): 3403–3412.
Published: 15 October 2008
...Chiharu Higashida; Shiro Suetsugu; Takahiro Tsuji; James Monypenny; Shuh Narumiya; Naoki Watanabe mDia1 belongs to the formin family of proteins that share FH1 and FH2 domains. Although formins play a critical role in the formation of many actin-based cellular structures, the physiological...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (19): 3475–3487.
Published: 01 October 2007
..., severing, contraction, bundling or engagement to the membrane. Mammalian Diaphanous-related (mDia) formins, which nucleate, processively elongate, and in some cases bundle actin filaments, have been extensively studied in vitro, but their function in the cell has been less well characterized. Here we study...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2005) 118 (13): 2837–2848.
Published: 01 July 2005
... stimulation, allowing the tethered MAPK cascade to be activated by Ste20, a Cdc42-anchored kinase. Here we show that stable recruitment of Ste5 at cortical sites requires the formin Bni1, Bni1-induced actin cables, Rho1 and Myo2. Rho1 directs recruitment of Bni1 via the Rho-binding domain, and Bni1 mediates...
Includes: Supplementary data
Journal Articles
J Cell Sci (2004) 117 (13): 2709–2720.
Published: 01 June 2004
..., linking innate and adaptive immune responses. The mechanisms enabling CD21 to independently relay information between the exterior and interior of the cell, however, remain unresolved. We show that formin homologue overexpressed in spleen (FHOS/FHOD1) binds the cytoplasmic domain of human CD21 through its...
Includes: Supplementary data