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Keywords: Force
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Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (3): jcs248385.
Published: 08 February 2021
... their metabolism to provide the energy necessary for cytoskeletal remodeling that occurs during cell migration, epithelial to mesenchymal transitions, and the cellular response to external forces. These studies have revealed that mechanotransduction, cell migration, and epithelial to mesenchymal transitions...
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2018) 131 (24): jcs216648.
Published: 14 December 2018
...Hannah Campbell; Christy Heidema; Daisy G. Pilarczyk; Kris A. DeMali ABSTRACT The response of cells to mechanical inputs is a key determinant of cell behavior. In response to external forces, E-cadherin initiates signal transduction cascades that allow the cell to modulate its contractility...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (2): 261–269.
Published: 15 January 2011
...Fanjie Meng; Frederick Sachs Mechanical forces are ubiquitous modulators of cell activity but little is known about the mechanical stresses in the cell. Genetically encoded FRET-based force sensors now allow the measurement of local stress in specific host proteins in vivo in real time...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2010) 123 (5): 712–722.
Published: 01 March 2010
... and motility. We used a dual pipette assay to measure the force required to separate E-cadherin-producing cell doublets and to investigate the role of integrin in regulating the strength of intercellular adhesion. A greater force was required to separate cell doublets bound to fibronectin or vitronectin-coated...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (20): 3644–3651.
Published: 15 October 2009
...Alexandra M. Goldyn; Borja Aragüés Rioja; Joachim P. Spatz; Christoph Ballestrem; Ralf Kemkemer Mechanical forces play a crucial role in controlling the integrity and functionality of cells and tissues. External forces are sensed by cells and translated into signals that induce various responses...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (5): 656–666.
Published: 01 March 2009
... traction forces. * Author for correspondence (e-mail: gbunt@gwdg.de ) 6 11 2008 © The Company of Biologists Limited 2009 2009 FERM conformation FAK FRET Migration ROCK Force Cell adhesion and migration are essential processes for embryonic development, wound healing...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (21): 3649–3663.
Published: 01 November 2008
... targeted membrane traffic and two force-generation mechanisms – hydrostatic pressure in a barrier-sealed volume and regulation of ROCK-mediated contractility – which act in parallel, to open up a lumen. These mechanisms might either regulate or be regulated by the accompanying morphometric changes...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (10): 1801–1809.
Published: 15 May 2007
...). The signaling mechanisms that mediate force-induced myofibroblast differentiation and SMA expression are not defined. We examined the role of the Rho–Rho-kinase pathway in force-induced SMA expression in fibroblasts using an in vitro model system that applies static tensile forces (0.65 pN/μm 2 ) to integrins...
Journal Articles
J Cell Sci (2006) 119 (9): 1886–1895.
Published: 01 May 2006
... monomers. A prominent requirement for α 2 β 1 integrins became apparent when fibroblasts executed mechanical tasks of high complexity in three-dimensional surroundings, such as contracting free-floating collagen gels and developing isometric forces in tethered lattices. The deficits observed for α 2...
Journal Articles
J Cell Sci (2005) 118 (2): 369–379.
Published: 15 January 2005
... frequency of transients in cells with a stretched, fibroblastic morphology is consistent with the idea that more elongated cells experience greater cytoskeletal tension. This is also supported by the finding that elongated fibroblast-shaped keratocytes generate larger traction forces than fan-shaped ones...
Journal Articles
J Cell Sci (2003) 116 (18): 3761–3770.
Published: 15 September 2003
... The Company of Biologists Limited 2003 2003 Chemotaxis Myosin Force Deformation Under-agarose assay Folate Dictyostelium Actin cross-linking Dictyostelium discoideum is a social, eukaryotic amoebae that normally moves through the soil using chemotaxis to folic acid to search...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2002) 115 (7): 1423–1433.
Published: 01 April 2002
... was quantified using a centrifugal detachment assay to assess the relative number of cells remaining adherent after a 10 minute application of defined distraction force. An unusual relationship between cell detachment and distraction force at relatively low values of applied force was found on substrates...