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Keywords: Focal adhesions
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J Cell Sci (2023) 136 (18): jcs261122.
Published: 28 September 2023
..., they are consistent with a previous study showing that focal adhesion kinase (FAK, also known as PTK2, another important FA protein) promotes HSC activation in vitro and liver fibrosis in vivo ( Zhao et al., 2017 ). Given that paxillin and FAK closely interact and are recruited early during FA formation, our...
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Series: REVIEW COMMONS TRANSFER
J Cell Sci (2022) 135 (7): jcs258764.
Published: 14 April 2022
... the spatial organization within focal adhesions by analyzing several adhesion proteins with structured illumination microscopy (SIM). Paxillin (Pax) serves as a scaffold protein and signaling hub in focal adhesions, and focal adhesion kinase (FAK, also known as PTK2) regulates the dynamics of adhesions. We...
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Adhesion
J Cell Sci (2022) 135 (2): jcs258471.
Published: 28 January 2022
..., integrin α6β4 distinctly distributed peripherally as well as centrally, proximal to the nucleus. Upon fibronectin addition, integrin α6β4 was centrally recruited to large focal adhesions (FAs) and enhanced Fak (also known as PTK2) phosphorylation. Integrin β4 plectin-binding mutants or genetic deletion...
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Adhesion
J Cell Sci (2021) 134 (8): jcs252221.
Published: 27 April 2021
..., cell spreading on galectin-8-coated substrates resulted in increased projected cell area, more-pronounced extension of filopodia and, yet, the inability to form focal adhesions and stress fibers. These differences can be partially reversed by experimental manipulations of small G-proteins of the Rho...
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Adhesion , Migration
J Cell Sci (2020) 133 (20): jcs244848.
Published: 22 October 2020
... adhesions and invadopodia initiation and maturation, despite the differences in their morphology and functions. Cell adhesion Cell invasion Integrin adhesions Mechanosensing Focal adhesions Invadopodia Israel Science Foundation 10.13039/501100003977 Cell-matrix interactions...
Journal Articles
J Cell Sci (2020) 133 (9): jcs242404.
Published: 11 May 2020
.../ Highlighted Article: Most integrins can bind several ligands. We show how one integrin, αVβ3, selects between two different ligands, fibronectin and vitronectin, based on force-regulated conformational changes in αVβ3 integrin. αVβ3 integrin ECM Ligand selection Focal adhesions Fibronectin...
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J Cell Sci (2019) 132 (10): jcs224030.
Published: 15 May 2019
..., and efficient cell spreading and migration. Clathrin Cell spreading Focal adhesions Integrin signaling National Institutes of Health GM-49217 Clathrin has well-established functions in cellular membrane trafficking events. These include mediating endocytosis of diverse cargoes from...
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Mechanobiology
J Cell Sci (2019) 132 (9): jcs229013.
Published: 30 April 2019
... into mechanobiology. Cellular biomechanics Focal adhesions Mechanobiology Nanotopography Viscoelasticity European Research Council 10.13039/100010663 282051 A variety of cellular processes, including cell morphology, polarisation, migration, stem cell differentiation and cancer...
Journal Articles
J Cell Sci (2019) 132 (8): jcs224493.
Published: 25 April 2019
... and effects on cell proliferation. On fibronectin, GFP-tagged β1A integrin showed dynamic exchange in peripheral focal adhesions, and long, central fibrillar adhesions. In contrast, GFP–β1D integrins exchanged slowly, forming immobile and short central adhesions. While adhesion recruitment of GFP–β1A integrin...
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Journal Articles
J Cell Sci (2017) 130 (1): 152–163.
Published: 1 January 2017
... GTPases (Rap1a and Rap1b, referred to collectively as Rap1). Under these conditions Rap1 activity stimulates the formation of focal adhesion structures that align with the tensional axis as single tumor cells move into the matrix. These effects are mediated by the ability of Rap1 to induce the polarized...
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Migration
J Cell Sci (2016) 129 (19): 3661–3674.
Published: 1 October 2016
... and talin2, respectively. Talin1 regulates focal adhesion dynamics, cell migration and invasion, whereas the biological function of talin2 is not clear and, indeed, talin2 has been presumed to function redundantly with talin1. Here, we show that talin2 has a much stronger binding to β-integrin tails than...
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J Cell Sci (2013) 126 (14): 3021–3030.
Published: 15 July 2013
...Ching-Wei Chang; Sanjay Kumar Summary Actomyosin stress fibers (SFs) enable cells to exert traction on planar extracellular matrices (ECMs) by tensing focal adhesions (FAs) at the cell–ECM interface. Although it is widely appreciated that the spatial and temporal distribution of these tensile...
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Journal Articles
J Cell Sci (2011) 124 (23): 3941–3955.
Published: 1 December 2011
... role of srGAP3 on actin dynamics, specifically on lamellipodia formation. We show that the F-BAR domain localizes srGAP3 to the leading edge of cellular protrusions whereas the SH3 domain is important for focal adhesion targeting. We report on a novel srGAP3 interaction partner, lamellipodin, which...
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Journal Articles
J Cell Sci (2011) 124 (11): 1808–1818.
Published: 1 June 2011
... ) ‡ These authors contributed equally to this work 10 1 2011 © 2011. 2011 Cell spreading Ezrin Focal adhesions Rap1 The response of cells following contact with an extracellular matrix, either for spreading or for migration, requires the tightly controlled regulation of cell adhesion...
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J Cell Sci (2011) 124 (9): 1425–1432.
Published: 1 May 2011
...Haguy Wolfenson; Alexander Bershadsky; Yoav I. Henis; Benjamin Geiger Focal adhesions (FAs) have key roles in the interaction of cells with the extracellular matrix (ECM) and in adhesion-mediated signaling. These dynamic, multi-protein structures sense the ECM both chemically and physically...
Includes: Supplementary data