Skip Nav Destination
Close Modal
Update search
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISBN
- EISBN
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISBN
- EISBN
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISBN
- EISBN
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISBN
- EISBN
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISBN
- EISBN
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISBN
- EISBN
- ISSN
- EISSN
- Issue
- Volume
- References
NARROW
Date
Availability
1-20 of 54
Keywords: Focal adhesions
Close
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
1
Sort by
Journal Articles
Bhagya Shree Choudhary, Nazia Chaudhary, Bushra K. Khan, Aditi Vijan, Dibita Mandal, Leena Pilankar, Shubham Gawand, Prerana Uttankar, Megha Sharma, Anusha Shivashankar, Rinki Doloi, Neha Joshi, Manjula Das, Sorab N. Dalal
Journal:
Journal of Cell Science
J Cell Sci jcs.263663.
Published: 13 May 2025
... to inhibiting actin glutathionylation, LCN2 stimulates invasion by promoting the formation of focal adhesions, which is independent of the ability of LCN2 to bind iron. LCN2 promotes focal adhesion formation by promoting the activation of c-Src by stimulating the expression of the transcription factor ETS1...
Journal Articles
c-Src-induced vascular malformations require localised matrix degradation at focal adhesions
Open AccessPatricia Essebier, Mikaela Keyser, Teodor Yordanov, Brittany Hill, Alexander Yu, Ivar Noordstra, Alpha S. Yap, Samantha J. Stehbens, Anne K. Lagendijk, Lilian Schimmel, Emma J. Gordon
Journal:
Journal of Cell Science
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2024) 137 (13): jcs262101.
Published: 10 July 2024
... and focal adhesion signalling. Here, we show that constitutive activation of c-Src in endothelial cells results in rapid vascular expansion, operating independently of growth factor stimulation or fluid shear stress forces. This is driven by an increase in focal adhesion signalling and size...
Includes: Supplementary data
Journal Articles
Paxillin regulates liver fibrosis via actin polymerization and ERK activation in hepatic stellate cells
Open Access
Journal:
Journal of Cell Science
J Cell Sci (2023) 136 (18): jcs261122.
Published: 28 September 2023
... in HSC activation and liver fibrosis. Although these findings are novel, they are consistent with a previous study showing that focal adhesion kinase (FAK, also known as PTK2, another important FA protein) promotes HSC activation in vitro and liver fibrosis in vivo ( Zhao et al., 2017 ). Given...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2022) 135 (7): jcs258764.
Published: 14 April 2022
... the spatial organization within focal adhesions by analyzing several adhesion proteins with structured illumination microscopy (SIM). Paxillin (Pax) serves as a scaffold protein and signaling hub in focal adhesions, and focal adhesion kinase (FAK, also known as PTK2) regulates the dynamics of adhesions. We...
Includes: Supplementary data
Journal Articles
Integrin α6β4 requires plectin and vimentin for adhesion complex distribution and invasive growth
FreeIn collection:
Adhesion
Journal:
Journal of Cell Science
J Cell Sci (2022) 135 (2): jcs258471.
Published: 28 January 2022
..., integrin α6β4 distinctly distributed peripherally as well as centrally, proximal to the nucleus. Upon fibronectin addition, integrin α6β4 was centrally recruited to large focal adhesions (FAs) and enhanced Fak (also known as PTK2) phosphorylation. Integrin β4 plectin-binding mutants or genetic deletion...
Includes: Supplementary data
Journal Articles
Differential cellular responses to adhesive interactions with galectin-8- and fibronectin-coated substrates
Open AccessIn collection:
Adhesion
Wenhong Li, Ana Sancho, Wen-Lu Chung, Yaron Vinik, Jürgen Groll, Yehiel Zick, Ohad Medalia, Alexander D. Bershadsky, Benjamin Geiger
Journal:
Journal of Cell Science
J Cell Sci (2021) 134 (8): jcs252221.
Published: 27 April 2021
..., cell spreading on galectin-8-coated substrates resulted in increased projected cell area, more-pronounced extension of filopodia and, yet, the inability to form focal adhesions and stress fibers. These differences can be partially reversed by experimental manipulations of small G-proteins of the Rho...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2020) 133 (20): jcs244848.
Published: 22 October 2020
... that drive early stages during the development of focal adhesions and invadopodia, and review distinct processes that lead to the maturation of the two integrin-associated adhesions. We hypothesize that adhesions to the ECM in both structures are initiated by shear forces that are generated by nearby...
Journal Articles
Michael Bachmann, Markus Schäfer, Vasyl V. Mykuliak, Marta Ripamonti, Lia Heiser, Kai Weißenbruch, Sarah Krübel, Clemens M. Franz, Vesa P. Hytönen, Bernhard Wehrle-Haller, Martin Bastmeyer
Journal:
Journal of Cell Science
J Cell Sci (2020) 133 (9): jcs242404.
Published: 11 May 2020
... , 1655 - 1699 . 10.1152/physrev.00036.2018 Ballestrem , C. , Hinz , B. , Imhof , B. A. and Wehrle-Haller , B. ( 2001 ). Marching at the front and dragging behind: differential alphaVbeta3-integrin turnover regulates focal adhesion behavior . J. Cell Biol. 155 , 1319 - 1332...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2019) 132 (10): jcs224030.
Published: 15 May 2019
.... Cell Sci. 124 , 820 - 830 . 10.1242/jcs.078832 Calalb , M. B. , Polte , T. R. and Hanks , S. K. ( 1995 ). Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases . Mol. Cell. Biol. 15...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
Journal:
Journal of Cell Science
J Cell Sci (2019) 132 (9): jcs229013.
Published: 30 April 2019
... ligand tether length affects the size and length of focal adhesions and influences cell spreading and attachment . Sci. Rep. 6 , 34334 . 10.1038/srep34334 Augst , A. D. , Kong , H. J. and Mooney , D. J. ( 2006 ). Alginate hydrogels as biomaterials . Macromol. Biosci. 6...
Journal Articles
Martinho Soto-Ribeiro, Birgit Kastberger, Michael Bachmann, Latifeh Azizi, Kenza Fouad, Marie-Claude Jacquier, David Boettiger, Daniel Bouvard, Martin Bastmeyer, Vesa P. Hytönen, Bernhard Wehrle-Haller
Journal:
Journal of Cell Science
J Cell Sci (2019) 132 (8): jcs224493.
Published: 25 April 2019
... and effects on cell proliferation. On fibronectin, GFP-tagged β1A integrin showed dynamic exchange in peripheral focal adhesions, and long, central fibrillar adhesions. In contrast, GFP–β1D integrins exchanged slowly, forming immobile and short central adhesions. While adhesion recruitment of GFP–β1A integrin...
Includes: Supplementary data
Journal Articles
Applied stretch initiates directional invasion through the action of Rap1 GTPase as a tension sensor
FreeSpencer A. Freeman, Sonja Christian, Pamela Austin, Irene Iu, Marcia L. Graves, Lin Huang, Shuo Tang, Daniel Coombs, Michael R. Gold, Calvin D. Roskelley
Journal:
Journal of Cell Science
J Cell Sci (2017) 130 (1): 152–163.
Published: 1 January 2017
... GTPases (Rap1a and Rap1b, referred to collectively as Rap1). Under these conditions Rap1 activity stimulates the formation of focal adhesion structures that align with the tensional axis as single tumor cells move into the matrix. These effects are mediated by the ability of Rap1 to induce the polarized...
Includes: Supplementary data
Journal Articles
In collection:
Cell migration
Lei Qi, Naser Jafari, Xiang Li, Zaozao Chen, Liqing Li, Vesa P. Hytönen, Benjamin T. Goult, Chang-Guo Zhan, Cai Huang
Journal:
Journal of Cell Science
J Cell Sci (2016) 129 (19): 3661–3674.
Published: 1 October 2016
... and talin2, respectively. Talin1 regulates focal adhesion dynamics, cell migration and invasion, whereas the biological function of talin2 is not clear and, indeed, talin2 has been presumed to function redundantly with talin1. Here, we show that talin2 has a much stronger binding to β-integrin tails than...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
Adil R. Sarhan, Trushar R. Patel, Alana R. Cowell, Michael G. Tomlinson, Carina Hellberg, John K. Heath, Debbie L. Cunningham, Neil A. Hotchin
Journal:
Journal of Cell Science
J Cell Sci (2016) 129 (15): 2962–2971.
Published: 1 August 2016
...Adil R. Sarhan; Trushar R. Patel; Alana R. Cowell; Michael G. Tomlinson; Carina Hellberg; John K. Heath; Debbie L. Cunningham; Neil A. Hotchin ABSTRACT Focal adhesions are complex multi-molecular structures that link the actin cytoskeleton to the extracellular matrix through integrin adhesion...
Journal Articles
In collection:
Mechanobiology
Journal:
Journal of Cell Science
J Cell Sci (2016) 129 (7): 1293–1304.
Published: 1 April 2016
...Ariel Livne; Benjamin Geiger ABSTRACT Ventral stress fibers and focal adhesions are physically coupled structures that play key roles in cellular mechanics and force sensing. The tight functional interdependence between the two is manifested not only by their apparent proximity but also by the fact...
Journal Articles
GEF-H1 controls focal adhesion signaling that regulates mesenchymal stem cell lineage commitment
Open AccessI-Husan Huang, Cheng-Te Hsiao, Jui-Chung Wu, Rong-Fong Shen, Ching-Yi Liu, Yang-Kao Wang, Yu-Chen Chen, Chi-Ming Huang, Juan C. del álamo, Zee-Fen Chang, Ming-Jer Tang, Kay-Hooi Khoo, Jean-Cheng Kuo
Journal:
Journal of Cell Science
J Cell Sci (2014) 127 (19): 4186–4200.
Published: 1 October 2014
...I-Husan Huang; Cheng-Te Hsiao; Jui-Chung Wu; Rong-Fong Shen; Ching-Yi Liu; Yang-Kao Wang; Yu-Chen Chen; Chi-Ming Huang; Juan C. del álamo; Zee-Fen Chang; Ming-Jer Tang; Kay-Hooi Khoo; Jean-Cheng Kuo ABSTRACT Focal adhesions (FAs) undergo maturation that culminates in size and composition changes...
Includes: Supplementary data
Journal Articles
Pradeep D. Uchil, Tobias Pawliczek, Tracy D. Reynolds, Siyuan Ding, Angelika Hinz, James B. Munro, Fang Huang, Robert W. Floyd, Haitao Yang, William L. Hamilton, Joerg Bewersdorf, Yong Xiong, David A. Calderwood, Walther Mothes
Journal:
Journal of Cell Science
J Cell Sci (2014) 127 (18): 3928–3942.
Published: 15 September 2014
...Pradeep D. Uchil; Tobias Pawliczek; Tracy D. Reynolds; Siyuan Ding; Angelika Hinz; James B. Munro; Fang Huang; Robert W. Floyd; Haitao Yang; William L. Hamilton; Joerg Bewersdorf; Yong Xiong; David A. Calderwood; Walther Mothes ABSTRACT Focal adhesions are macromolecular complexes that connect...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2013) 126 (14): 3021–3030.
Published: 15 July 2013
...Ching-Wei Chang; Sanjay Kumar Summary Actomyosin stress fibers (SFs) enable cells to exert traction on planar extracellular matrices (ECMs) by tensing focal adhesions (FAs) at the cell–ECM interface. Although it is widely appreciated that the spatial and temporal distribution of these tensile...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2011) 124 (23): 3941–3955.
Published: 1 December 2011
... role of srGAP3 on actin dynamics, specifically on lamellipodia formation. We show that the F-BAR domain localizes srGAP3 to the leading edge of cellular protrusions whereas the SH3 domain is important for focal adhesion targeting. We report on a novel srGAP3 interaction partner, lamellipodin, which...
Includes: Multimedia, Supplementary data
Journal Articles
Sarah H. Ross, Anneke Post, Judith H. Raaijmakers, Ingrid Verlaan, Martijn Gloerich, Johannes L. Bos
Journal:
Journal of Cell Science
J Cell Sci (2011) 124 (11): 1808–1818.
Published: 1 June 2011
... ) ‡ These authors contributed equally to this work 10 1 2011 © 2011. 2011 Cell spreading Ezrin Focal adhesions Rap1 The response of cells following contact with an extracellular matrix, either for spreading or for migration, requires the tightly controlled regulation of cell adhesion...
Includes: Supplementary data
1