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Keywords: Focal adhesions
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Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2022) 135 (7): jcs258764.
Published: 14 April 2022
... the spatial organization within focal adhesions by analyzing several adhesion proteins with structured illumination microscopy (SIM). Paxillin (Pax) serves as a scaffold protein and signaling hub in focal adhesions, and focal adhesion kinase (FAK, also known as PTK2) regulates the dynamics of adhesions. We...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2022) 135 (2): jcs258471.
Published: 28 January 2022
..., integrin α6β4 distinctly distributed peripherally as well as centrally, proximal to the nucleus. Upon fibronectin addition, integrin α6β4 was centrally recruited to large focal adhesions (FAs) and enhanced Fak (also known as PTK2) phosphorylation. Integrin β4 plectin-binding mutants or genetic deletion...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2021) 134 (8): jcs252221.
Published: 27 April 2021
..., cell spreading on galectin-8-coated substrates resulted in increased projected cell area, more-pronounced extension of filopodia and, yet, the inability to form focal adhesions and stress fibers. These differences can be partially reversed by experimental manipulations of small G-proteins of the Rho...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (20): jcs244848.
Published: 22 October 2020
... of invadopodia. In this Hypothesis, we discuss common mechanisms that drive early stages during the development of focal adhesions and invadopodia, and review distinct processes that lead to the maturation of the two integrin-associated adhesions. We hypothesize that adhesions to the ECM in both...
Journal Articles
J Cell Sci (2020) 133 (9): jcs242404.
Published: 11 May 2020
.... ( 2001 ). Marching at the front and dragging behind: differential alphaVbeta3-integrin turnover regulates focal adhesion behavior . J. Cell Biol.   155 , 1319 - 1332 . 10.1083/jcb.200107107 Benito-Jardón , M. , Klapproth , S. , Gimeno-LLuch , I. , Petzold , T. , Bharadwaj , M...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (10): jcs224030.
Published: 15 May 2019
..., and efficient cell spreading and migration. Clathrin Cell spreading Focal adhesions Integrin signaling Clathrin has well-established functions in cellular membrane trafficking events. These include mediating endocytosis of diverse cargoes from coated pits in the plasma membrane, sorting...
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Journal Articles
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Mechanobiology
J Cell Sci (2019) 132 (9): jcs229013.
Published: 30 April 2019
... length affects the size and length of focal adhesions and influences cell spreading and attachment . Sci. Rep.   6 , 34334 . 10.1038/srep34334 Augst , A. D. , Kong , H. J. and Mooney , D. J. ( 2006 ). Alginate hydrogels as biomaterials . Macromol. Biosci.   6 , 623 - 633...
Journal Articles
J Cell Sci (2019) 132 (8): jcs224493.
Published: 25 April 2019
... and effects on cell proliferation. On fibronectin, GFP-tagged β1A integrin showed dynamic exchange in peripheral focal adhesions, and long, central fibrillar adhesions. In contrast, GFP–β1D integrins exchanged slowly, forming immobile and short central adhesions. While adhesion recruitment of GFP–β1A integrin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (1): 152–163.
Published: 1 January 2017
... GTPases (Rap1a and Rap1b, referred to collectively as Rap1). Under these conditions Rap1 activity stimulates the formation of focal adhesion structures that align with the tensional axis as single tumor cells move into the matrix. These effects are mediated by the ability of Rap1 to induce the polarized...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (19): 3661–3674.
Published: 1 October 2016
... and talin2, respectively. Talin1 regulates focal adhesion dynamics, cell migration and invasion, whereas the biological function of talin2 is not clear and, indeed, talin2 has been presumed to function redundantly with talin1. Here, we show that talin2 has a much stronger binding to β-integrin tails than...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2016) 129 (15): 2962–2971.
Published: 1 August 2016
...Adil R. Sarhan; Trushar R. Patel; Alana R. Cowell; Michael G. Tomlinson; Carina Hellberg; John K. Heath; Debbie L. Cunningham; Neil A. Hotchin ABSTRACT Focal adhesions are complex multi-molecular structures that link the actin cytoskeleton to the extracellular matrix through integrin adhesion...
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2016) 129 (7): 1293–1304.
Published: 1 April 2016
...Ariel Livne; Benjamin Geiger ABSTRACT Ventral stress fibers and focal adhesions are physically coupled structures that play key roles in cellular mechanics and force sensing. The tight functional interdependence between the two is manifested not only by their apparent proximity but also by the fact...
Journal Articles
J Cell Sci (2014) 127 (19): 4186–4200.
Published: 1 October 2014
...I-Husan Huang; Cheng-Te Hsiao; Jui-Chung Wu; Rong-Fong Shen; Ching-Yi Liu; Yang-Kao Wang; Yu-Chen Chen; Chi-Ming Huang; Juan C. del álamo; Zee-Fen Chang; Ming-Jer Tang; Kay-Hooi Khoo; Jean-Cheng Kuo ABSTRACT Focal adhesions (FAs) undergo maturation that culminates in size and composition changes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (18): 3928–3942.
Published: 15 September 2014
...Pradeep D. Uchil; Tobias Pawliczek; Tracy D. Reynolds; Siyuan Ding; Angelika Hinz; James B. Munro; Fang Huang; Robert W. Floyd; Haitao Yang; William L. Hamilton; Joerg Bewersdorf; Yong Xiong; David A. Calderwood; Walther Mothes ABSTRACT Focal adhesions are macromolecular complexes that connect...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (14): 3021–3030.
Published: 15 July 2013
...Ching-Wei Chang; Sanjay Kumar Summary Actomyosin stress fibers (SFs) enable cells to exert traction on planar extracellular matrices (ECMs) by tensing focal adhesions (FAs) at the cell–ECM interface. Although it is widely appreciated that the spatial and temporal distribution of these tensile...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (23): 3941–3955.
Published: 1 December 2011
... role of srGAP3 on actin dynamics, specifically on lamellipodia formation. We show that the F-BAR domain localizes srGAP3 to the leading edge of cellular protrusions whereas the SH3 domain is important for focal adhesion targeting. We report on a novel srGAP3 interaction partner, lamellipodin, which...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (11): 1808–1818.
Published: 1 June 2011
... ) ‡ These authors contributed equally to this work 10 1 2011 © 2011. 2011 Cell spreading Ezrin Focal adhesions Rap1 The response of cells following contact with an extracellular matrix, either for spreading or for migration, requires the tightly controlled regulation of cell adhesion...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (9): 1425–1432.
Published: 1 May 2011
...Haguy Wolfenson; Alexander Bershadsky; Yoav I. Henis; Benjamin Geiger Focal adhesions (FAs) have key roles in the interaction of cells with the extracellular matrix (ECM) and in adhesion-mediated signaling. These dynamic, multi-protein structures sense the ECM both chemically and physically...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (1): 118–127.
Published: 1 January 2010
... is a resident of focal adhesions. © 2010. 2010 Cell adhesion Cell motility Focal adhesions Dystroglycan Vinculin Vinexin The adhesion of cells to each other and to their substrate is key to generating cell shape and cell organisation in tissues. Understanding how cells adhere is important...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (18): 3225–3232.
Published: 15 September 2009
...Claudia Asperti; Veronica Astro; Antonio Totaro; Simona Paris; Ivan de Curtis Integrin activation is needed to link the extracellular matrix with the actin cytoskeleton during cell motility. Protrusion requires coordination of actin dynamics with focal-adhesion turnover. We report that the adaptor...
Includes: Multimedia, Supplementary data