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Keywords: Focal adhesion kinase
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Journal Articles
In collection:
Adhesion , Cytoskeleton
J Cell Sci (2021) 134 (13): jcs258321.
Published: 08 July 2021
... regime, we found that, in mononucleated macrophages, focal adhesion kinase (FAK; also known as PTK2) is involved in regulating the adhesion area during optogenetically induced furrow formation, while the actin-bundling protein fascin is involved in regulating the height. This allows the cell to generate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (8): 1580–1591.
Published: 15 April 2016
... and monocyte adhesion. Like for other atherogenic factors, oxLDL-induced proinflammatory responses requires integrin-dependent focal adhesion kinase (FAK, also known as PTK2) signaling; however, the mechanism by which FAK mediates oxLDL-dependent NF-κB signaling has yet to be revealed. We now show that oxLDL...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (24): 4601–4614.
Published: 15 December 2015
... contributes to fascin-dependent control of focal adhesion dynamics and cell migration speed. We also show that fascin forms a complex with focal adhesion kinase (FAK, also known as PTK2) and Src, and that this signalling pathway lies downstream of fascin–microtubule association in the control of adhesion...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (7): 1394–1405.
Published: 01 April 2014
.... Furthermore, we found that CasSD phosphorylation in the early stages of cell spreading required: (1) integrin anchorage and integrin-mediated activation of SFKs, (2) association of Cas with focal adhesion kinase (FAK), and (3) N-WASP-driven actin-assembly activity. These findings, and analyses...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (24): 5960–5973.
Published: 15 December 2012
... Lee Summary Transmembrane 4 L six family member 5 (TM4SF5) plays an important role in cell migration, and focal adhesion kinase (FAK) activity is essential for homeostatic and pathological migration of adherent cells. However, it is unclear how TM4SF5 signaling mediates the activation of cellular...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (2): 171–180.
Published: 15 January 2010
... by normal MDCK cells, myosin-II and focal adhesion kinase (FAK) are activated in Src cells, which further activate downstream mitogen-activated protein kinase (MAPK). Importantly, activation of these signalling pathways depends on the presence of surrounding normal cells and plays a crucial role in apical...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (3): 357–367.
Published: 01 February 2009
... differentiate or undergo apoptosis depending on their local adhesive interactions. Apoptosis in response to an inappropriate ECM environment is termed `anoikis', or homelessness. Several studies, utilising a variety of cell types, have indicated a common, crucial role for focal adhesion kinase (FAK...
Journal Articles
J Cell Sci (2006) 119 (1): 47–55.
Published: 01 January 2006
... activity is required for netrin to stimulate UNC5 tyrosine phosphorylation in neurons and transfected cells. The SH2 domain of Src kinase directly interacts with the cytosolic domain of UNC5 in a tyrosine-phosphorylation-dependent manner. Furthermore, the tyrosine kinase focal adhesion kinase (FAK) is also...
Journal Articles
J Cell Sci (2005) 118 (19): 4415–4425.
Published: 01 October 2005
...Abdelkader Hamadi; Maya Bouali; Monique Dontenwill; Herrade Stoeckel; Kenneth Takeda; Philippe Rondé One of the major tyrosine phosphorylation activities linked to integrin signalling is that of focal adhesion kinase (FAK). High amounts of FAK are located at specialised subcellular compartments...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2005) 118 (10): 2189–2200.
Published: 15 May 2005
... Limited 2005 2005 Actin cytoskeleton Fibronectin Staphylococci Focal complexes Focal adhesion kinase Cortactin Integrins are heterodimeric surface receptors of multicellular organisms critically involved in cell-cell and cell-matrix adhesion. In addition to their structural role...
Includes: Supplementary data
Journal Articles
J Cell Sci (2003) 116 (14): 2845–2855.
Published: 15 July 2003
... and cytoskeletal proteins, the SETA-interacting protein AIP1, which is a rat ortholog of the Xenopus src substrate Xp95, strongly interacted with structural proteins of the cytoskeleton, including actin and tubulins. Both SETA and AIP1 interacted with focal adhesion kinase (FAK) and proline rich tyrosine kinase 2...
Journal Articles
J Cell Sci (2003) 116 (6): 975–986.
Published: 15 March 2003
... adhesion development by inducing cellular contraction. We show here that, 2 minutes after addition of the microtubule-disrupting drug nocodazole,the local densities of the focal adhesion-associated proteins vinculin,paxillin and focal adhesion kinase (FAK) are significantly elevated and the focal adhesion...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2001) 114 (14): 2665–2672.
Published: 15 July 2001
... of a kinase-inactive Src mutant suppressed invasion. Our results suggest that signals initiated by αvβ3 promote metastasis in K1735 melanoma cells through the phosphorylation of FAK and activation of Src. © The Company of Biologists Limited 2001 2001 β3 integrins Melanoma Focal adhesion kinase Src...
Journal Articles
J Cell Sci (1994) 1994 (Supplement_18): 109–113.
Published: 01 January 1994
... of the cell. This brief review considers recent information on the role of focal adhesion-associated protein tyrosine kinases in integrin-regulated cell signalling. * Author for correspondence © The Company of Biologists Limited 1994 1994 integrin paxillin focal adhesion kinase Journal...