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1-20 of 24
Keywords: Focal adhesion kinase
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Journal Articles
Point contact-restricted cAMP signaling controls ephrin-A5-induced axon repulsion
Available to PurchaseJohann Bécret, Claudia Gomez-Bravo, Camille Michaud, Ahlem Assali, Naïg A. L. Chenais, Izeta Kankadze, Fiona Roche, Sandrine Couvet, Coralie Fassier, Xavier Nicol
Journal:
Journal of Cell Science
J Cell Sci (2025) 138 (2): JCS263480.
Published: 22 January 2025
... emerged as a flexible strategy to reach such a specificity. Here, we show that point contact-restricted cAMP signals control ephrin-A5-evoked axon repulsion in vitro by modulating focal adhesion kinase (FAK; also known as PTK2) phosphorylation and the assembly and disassembly rate of point contacts...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2024) 137 (14): jcs261723.
Published: 22 July 2024
...David D. Schlaepfer; Marjaana Ojalill; Dwayne G. Stupack ABSTRACT Focal adhesion kinase (FAK; encoded by PTK2) was discovered over 30 years ago as a cytoplasmic protein tyrosine kinase that is localized to cell adhesion sites, where it is activated by integrin receptor binding to extracellular...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2022) 135 (20): jcs259089.
Published: 14 October 2022
...Johanne Le Coq; Iván Acebrón; Bárbara Rodrigo Martin; Pilar López Navajas; Daniel Lietha ABSTRACT Focal adhesion kinase (FAK; also known as PTK2) was discovered three decades ago and is now recognised as a key player in the regulation of cell–matrix adhesion and mesenchymal cell migration. Although...
Journal Articles
Integrin α6β4 requires plectin and vimentin for adhesion complex distribution and invasive growth
FreeIn collection:
Adhesion
Journal:
Journal of Cell Science
J Cell Sci (2022) 135 (2): jcs258471.
Published: 28 January 2022
... with other integrins to drive migration and invasive growth. Integrin α6β4 Triple negative breast cancer Focal adhesions Fibrillar adhesions Focal adhesion kinase Vimentin National Institutes of Health http://dx.doi.org/10.13039/100000002 R01 CA223164-01 Markey Women Strong...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2021) 134 (13): jcs258321.
Published: 8 July 2021
... by The Company of Biologists Ltd 2021 Highlighted Article: Fascin and focal adhesion kinase work in conjunction to regulate cell morphology during shape-altering processes such as furrow formation by controlling height and adhesion area, respectively. Cell shape Fascin Focal adhesion kinase...
Includes: Supplementary data
Journal Articles
Oxidized LDL induces FAK-dependent RSK signaling to drive NF-κB activation and VCAM-1 expression
FreeArif Yurdagul, Jr, Florian J. Sulzmaier, Xiao L. Chen, Christopher B. Pattillo, David D. Schlaepfer, A. Wayne Orr
Journal:
Journal of Cell Science
J Cell Sci (2016) 129 (8): 1580–1591.
Published: 15 April 2016
... and monocyte adhesion. Like for other atherogenic factors, oxLDL-induced proinflammatory responses requires integrin-dependent focal adhesion kinase (FAK, also known as PTK2) signaling; however, the mechanism by which FAK mediates oxLDL-dependent NF-κB signaling has yet to be revealed. We now show that oxLDL...
Includes: Supplementary data
Journal Articles
A direct interaction between fascin and microtubules contributes to adhesion dynamics and cell migration
Open AccessGiulia Villari, Asier Jayo, Jennifer Zanet, Briana Fitch, Bryan Serrels, Margaret Frame, Brian M. Stramer, Benjamin T. Goult, Maddy Parsons
Journal:
Journal of Cell Science
J Cell Sci (2015) 128 (24): 4601–4614.
Published: 15 December 2015
... contributes to fascin-dependent control of focal adhesion dynamics and cell migration speed. We also show that fascin forms a complex with focal adhesion kinase (FAK, also known as PTK2) and Src, and that this signalling pathway lies downstream of fascin–microtubule association in the control of adhesion...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2014) 127 (7): 1394–1405.
Published: 1 April 2014
.... Furthermore, we found that CasSD phosphorylation in the early stages of cell spreading required: (1) integrin anchorage and integrin-mediated activation of SFKs, (2) association of Cas with focal adhesion kinase (FAK), and (3) N-WASP-driven actin-assembly activity. These findings, and analyses...
Includes: Supplementary data
Journal Articles
Oisun Jung, Suyong Choi, Sun-Bok Jang, Sin-Ae Lee, Ssang-Taek Lim, Yoon-Ju Choi, Hye-Jin Kim, Do-Hee Kim, Tae Kyoung Kwak, Hyeonjung Kim, Minkyung Kang, Mi-Sook Lee, Sook Young Park, Jihye Ryu, Doyoung Jeong, Hae-Kap Cheong, Hyun Jeong Kim, Ki Hun Park, Bong-Jin Lee, David D. Schlaepfer, Jung Weon Lee
Journal:
Journal of Cell Science
J Cell Sci (2012) 125 (24): 5960–5973.
Published: 15 December 2012
... Lee Summary Transmembrane 4 L six family member 5 (TM4SF5) plays an important role in cell migration, and focal adhesion kinase (FAK) activity is essential for homeostatic and pathological migration of adherent cells. However, it is unclear how TM4SF5 signaling mediates the activation of cellular...
Includes: Supplementary data
Journal Articles
Mihoko Kajita, Catherine Hogan, Andrew R. Harris, Sophie Dupre-Crochet, Nobue Itasaki, Koichi Kawakami, Guillaume Charras, Masazumi Tada, Yasuyuki Fujita
Journal:
Journal of Cell Science
J Cell Sci (2010) 123 (2): 171–180.
Published: 15 January 2010
... by normal MDCK cells, myosin-II and focal adhesion kinase (FAK) are activated in Src cells, which further activate downstream mitogen-activated protein kinase (MAPK). Importantly, activation of these signalling pathways depends on the presence of surrounding normal cells and plays a crucial role in apical...
Includes: Multimedia, Supplementary data
Journal Articles
Nadia K. Zouq, James A. Keeble, Jennefer Lindsay, Anthony J. Valentijn, Lu Zhang, Deborah Mills, Christopher E. Turner, Charles H. Streuli, Andrew P. Gilmore
Journal:
Journal of Cell Science
J Cell Sci (2009) 122 (3): 357–367.
Published: 1 February 2009
... differentiate or undergo apoptosis depending on their local adhesive interactions. Apoptosis in response to an inappropriate ECM environment is termed `anoikis', or homelessness. Several studies, utilising a variety of cell types, have indicated a common, crucial role for focal adhesion kinase (FAK...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2006) 119 (1): 47–55.
Published: 1 January 2006
... activity is required for netrin to stimulate UNC5 tyrosine phosphorylation in neurons and transfected cells. The SH2 domain of Src kinase directly interacts with the cytosolic domain of UNC5 in a tyrosine-phosphorylation-dependent manner. Furthermore, the tyrosine kinase focal adhesion kinase (FAK) is also...
Journal Articles
Regulation of focal adhesion dynamics and disassembly by phosphorylation of FAK at tyrosine 397
FreeAbdelkader Hamadi, Maya Bouali, Monique Dontenwill, Herrade Stoeckel, Kenneth Takeda, Philippe Rondé
Journal:
Journal of Cell Science
J Cell Sci (2005) 118 (19): 4415–4425.
Published: 1 October 2005
...Abdelkader Hamadi; Maya Bouali; Monique Dontenwill; Herrade Stoeckel; Kenneth Takeda; Philippe Rondé One of the major tyrosine phosphorylation activities linked to integrin signalling is that of focal adhesion kinase (FAK). High amounts of FAK are located at specialised subcellular compartments...
Includes: Multimedia, Supplementary data
Journal Articles
Cellular invasion by Staphylococcus aureus reveals a functional link between focal adhesion kinase and cortactin in integrin-mediated internalisation
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2005) 118 (10): 2189–2200.
Published: 15 May 2005
... 2005 2005 Actin cytoskeleton Fibronectin Staphylococci Focal complexes Focal adhesion kinase Cortactin Integrins are heterodimeric surface receptors of multicellular organisms critically involved in cell-cell and cell-matrix adhesion. In addition to their structural role, integrins...
Includes: Supplementary data
Journal Articles
SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse cytoskeletal elements, including FAKs, and modulate cell adhesion
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2003) 116 (14): 2845–2855.
Published: 15 July 2003
... and cytoskeletal proteins, the SETA-interacting protein AIP1, which is a rat ortholog of the Xenopus src substrate Xp95, strongly interacted with structural proteins of the cytoskeleton, including actin and tubulins. Both SETA and AIP1 interacted with focal adhesion kinase (FAK) and proline rich tyrosine kinase 2...
Journal Articles
Live-cell monitoring of tyrosine phosphorylation in focal adhesions following microtubule disruption
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2003) 116 (6): 975–986.
Published: 15 March 2003
... adhesion development by inducing cellular contraction. We show here that, 2 minutes after addition of the microtubule-disrupting drug nocodazole,the local densities of the focal adhesion-associated proteins vinculin,paxillin and focal adhesion kinase (FAK) are significantly elevated and the focal adhesion...
Includes: Multimedia, Supplementary data
Journal Articles
Integrin αvβ3 mediates K1735 murine melanoma cell motility in vivo and in vitro
Available to PurchaseXiaowu Li, Joseph Regezi, F. Patrick Ross, Scott Blystone, Duško Ilić, Stanley P. L. Leong, Daniel M. Ramos
Journal:
Journal of Cell Science
J Cell Sci (2001) 114 (14): 2665–2672.
Published: 15 July 2001
... distribution in malignant melanoma: association of the β 3 subunit with tumor progression. Cancer Res. 50 , 6757 -6764. Calalb, M. B., Zhang, X., Polte, T. R. and Hanks, S. K. (1996). Focal adhesion kinase tyrosine-861 is a major site of phosphorylation by Src. Biochem. Biophy. Res. Comm. 228 (3...
Journal Articles
Clustering of cell surface β1,4-galactosyltransferase I induces transient tyrosine phosphorylation of focal adhesion kinase and loss of stress fibers
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2000) 113 (2): 237–245.
Published: 15 January 2000
... Focal adhesion kinase Cytoskeleton The extracellular matrix (ECM) plays a critical role in modulating the morphology, growth, migration and differentiation of cells (Streuli et al., 1991 ; Juliano and Haskill, 1993). An extensive body of work has addressed the signal transduction pathways...
Journal Articles
Differential activation of focal adhesion kinase, Rho and Rac by the ninth and tenth FIII domains of fibronectin
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (1999) 112 (17): 2937–2946.
Published: 1 September 1999
... bind to the ninth and tenth FIII domains, FIII9-10. Integrin-mediated signal transduction involves activation of signaling pathways of the growth factor-dependent Ras-related small GTP-binding proteins Rho and Rac, and phosphorylation of focal adhesion kinase. We have dissected the requirement of FIII9...
Journal Articles
Expression and characterization of splice variants of PYK2, a focal adhesion kinase-related protein
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (1998) 111 (14): 1981–1991.
Published: 30 July 1998
...Wen-Cheng Xiong; Marlene Macklem; J. Thomas Parsons ABSTRACT Focal adhesion kinase and the recently identified proline-rich tyrosine kinase 2 (PYK2), also known as cell adhesion kinase β, related adhesion focal tyrosine kinase or calcium-dependent protein tyrosine kinase, define a new family of non...
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