... emerged as a flexible strategy to reach such a specificity. Here, we show that point contact-restricted cAMP signals control ephrin-A5-evoked axon repulsion in vitro by modulating focal adhesion kinase (FAK; also known as PTK2) phosphorylation and the assembly and disassembly rate of point contacts...

...David D. Schlaepfer; Marjaana Ojalill; Dwayne G. Stupack ABSTRACT Focal adhesion kinase (FAK; encoded by PTK2) was discovered over 30 years ago as a cytoplasmic protein tyrosine kinase that is localized to cell adhesion sites, where it is activated by integrin receptor binding to extracellular...

...Johanne Le Coq; Iván Acebrón; Bárbara Rodrigo Martin; Pilar López Navajas; Daniel Lietha ABSTRACT Focal adhesion kinase (FAK; also known as PTK2) was discovered three decades ago and is now recognised as a key player in the regulation of cell–matrix adhesion and mesenchymal cell migration. Although...

... with other integrins to drive migration and invasive growth. Integrin α6β4 Triple negative breast cancer Focal adhesions Fibrillar adhesions Focal adhesion kinase Vimentin National Institutes of Health http://dx.doi.org/10.13039/100000002 R01 CA223164-01 Markey Women Strong...

... by The Company of Biologists Ltd 2021 Highlighted Article: Fascin and focal adhesion kinase work in conjunction to regulate cell morphology during shape-altering processes such as furrow formation by controlling height and adhesion area, respectively. Cell shape Fascin Focal adhesion kinase...

... and monocyte adhesion. Like for other atherogenic factors, oxLDL-induced proinflammatory responses requires integrin-dependent focal adhesion kinase (FAK, also known as PTK2) signaling; however, the mechanism by which FAK mediates oxLDL-dependent NF-κB signaling has yet to be revealed. We now show that oxLDL...

... contributes to fascin-dependent control of focal adhesion dynamics and cell migration speed. We also show that fascin forms a complex with focal adhesion kinase (FAK, also known as PTK2) and Src, and that this signalling pathway lies downstream of fascin–microtubule association in the control of adhesion...

.... Furthermore, we found that CasSD phosphorylation in the early stages of cell spreading required: (1) integrin anchorage and integrin-mediated activation of SFKs, (2) association of Cas with focal adhesion kinase (FAK), and (3) N-WASP-driven actin-assembly activity. These findings, and analyses...

... Lee Summary Transmembrane 4 L six family member 5 (TM4SF5) plays an important role in cell migration, and focal adhesion kinase (FAK) activity is essential for homeostatic and pathological migration of adherent cells. However, it is unclear how TM4SF5 signaling mediates the activation of cellular...

... by normal MDCK cells, myosin-II and focal adhesion kinase (FAK) are activated in Src cells, which further activate downstream mitogen-activated protein kinase (MAPK). Importantly, activation of these signalling pathways depends on the presence of surrounding normal cells and plays a crucial role in apical...

... differentiate or undergo apoptosis depending on their local adhesive interactions. Apoptosis in response to an inappropriate ECM environment is termed `anoikis', or homelessness. Several studies, utilising a variety of cell types, have indicated a common, crucial role for focal adhesion kinase (FAK...

... activity is required for netrin to stimulate UNC5 tyrosine phosphorylation in neurons and transfected cells. The SH2 domain of Src kinase directly interacts with the cytosolic domain of UNC5 in a tyrosine-phosphorylation-dependent manner. Furthermore, the tyrosine kinase focal adhesion kinase (FAK) is also...

...Abdelkader Hamadi; Maya Bouali; Monique Dontenwill; Herrade Stoeckel; Kenneth Takeda; Philippe Rondé One of the major tyrosine phosphorylation activities linked to integrin signalling is that of focal adhesion kinase (FAK). High amounts of FAK are located at specialised subcellular compartments...

... 2005 2005 Actin cytoskeleton Fibronectin Staphylococci Focal complexes Focal adhesion kinase Cortactin Integrins are heterodimeric surface receptors of multicellular organisms critically involved in cell-cell and cell-matrix adhesion. In addition to their structural role, integrins...

... and cytoskeletal proteins, the SETA-interacting protein AIP1, which is a rat ortholog of the Xenopus src substrate Xp95, strongly interacted with structural proteins of the cytoskeleton, including actin and tubulins. Both SETA and AIP1 interacted with focal adhesion kinase (FAK) and proline rich tyrosine kinase 2...

... adhesion development by inducing cellular contraction. We show here that, 2 minutes after addition of the microtubule-disrupting drug nocodazole,the local densities of the focal adhesion-associated proteins vinculin,paxillin and focal adhesion kinase (FAK) are significantly elevated and the focal adhesion...

... distribution in malignant melanoma: association of the β 3 subunit with tumor progression. Cancer Res. 50 , 6757 -6764. Calalb, M. B., Zhang, X., Polte, T. R. and Hanks, S. K. (1996). Focal adhesion kinase tyrosine-861 is a major site of phosphorylation by Src. Biochem. Biophy. Res. Comm. 228 (3...

... Focal adhesion kinase Cytoskeleton The extracellular matrix (ECM) plays a critical role in modulating the morphology, growth, migration and differentiation of cells (Streuli et al., 1991 ; Juliano and Haskill, 1993). An extensive body of work has addressed the signal transduction pathways...

... bind to the ninth and tenth FIII domains, FIII9-10. Integrin-mediated signal transduction involves activation of signaling pathways of the growth factor-dependent Ras-related small GTP-binding proteins Rho and Rac, and phosphorylation of focal adhesion kinase. We have dissected the requirement of FIII9...

...Wen-Cheng Xiong; Marlene Macklem; J. Thomas Parsons ABSTRACT Focal adhesion kinase and the recently identified proline-rich tyrosine kinase 2 (PYK2), also known as cell adhesion kinase β, related adhesion focal tyrosine kinase or calcium-dependent protein tyrosine kinase, define a new family of non...