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Keywords: Focal adhesion
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Journal Articles
Journal Articles
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In collection:
Adhesion , Cytoskeleton
J Cell Sci (2022) 135 (11): jcs259465.
Published: 6 June 2022
...Alba Zuidema; Wei Wang; Maaike Kreft; Onno B. Bleijerveld; Liesbeth Hoekman; Jonas Aretz; Ralph T. Böttcher; Reinhard Fässler; Arnoud Sonnenberg ABSTRACT The vitronectin receptor integrin αVβ5 can reside in two distinct adhesion structures – focal adhesions (FAs) and flat clathrin lattices (FCLs...
Includes: Supplementary data
Journal Articles
In collection:
Cell Migration
J Cell Sci (2022) 135 (4): jcs259138.
Published: 18 February 2022
... glycosylation. ALFY WDFY3 Endosome Migration Focal adhesion Integrin Norges Forskningsråd http://dx.doi.org/10.13039/501100005416 262652 314684 249753 Norwegian Cancer Society http://dx.doi.org/10.13039/100008730 190251 Hereditary Disease Foundation http...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion , Imaging
J Cell Sci (2022) 135 (3): jcs259430.
Published: 3 February 2022
... contain the non-neuronal proteins LL5β (also known as PHLDB2) and KANK1, which, in migrating cells, organize exocytotic machinery in the vicinity of integrin-based adhesions. Depletion of LL5β or focal adhesion disassembly triggered by myosin II inhibition perturbed the clustering of secretory complexes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (4): jcs254029.
Published: 17 February 2021
...Yi-Chun Liao; Su Hao Lo ABSTRACT Tensins are a family of focal adhesion proteins consisting of four members in mammals (TNS1, TNS2, TNS3 and TNS4). Their multiple domains and activities contribute to the molecular linkage between the extracellular matrix and cytoskeletal networks, as well...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2020) 133 (1): jcs231134.
Published: 3 January 2020
... 2019 © 2020. Published by The Company of Biologists Ltd 2020 http://www.biologists.com/user-licence-1-1/ Highlighted Article: Intracellular transglutaminase 2 influences cellular mechanical state, focal adhesion dynamic and FAK activation in response to substrate stiffness, in part...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion , Cytoskeleton
J Cell Sci (2019) 132 (19): jcs232843.
Published: 9 October 2019
... their participation in adhesion turnover and cellular signalling. In this Review, we focus on the interactions between microtubules and integrin-mediated adhesions, in particular, focal adhesions and podosomes. Starting with the association of microtubules with these adhesive structures, we describe the classical...
Journal Articles
J Cell Sci (2019) 132 (17): jcs225383.
Published: 2 September 2019
... density of inward-rectifier K + channels (K ir 2.1; encoded by KCNJ2 ) and profoundly alter the action potential shape of excitable cells. By using micropatterning to manipulate the localization and size of focal adhesions (FAs) in single HEK293 cells engineered to stably express K ir 2.1 channels...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (7): jcs226514.
Published: 3 April 2019
..., as well as for cell migration. Focal adhesions are complex and highly dynamic structures organized around the cytosolic tails of activated β-integrin adhesion receptors ( Zaidel-Bar and Geiger, 2010 ; Wehrle-Haller, 2012 ; Horton et al., 2015 ). Talins are focal adhesion scaffold proteins...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2019) 132 (2): jcs217349.
Published: 21 January 2019
... gene), both of which localize to focal adhesions, cooperatively function as mechanosensors of ECM stiffness. On a rigid ECM, vinexin α interacts with vinculin and induces a conformational change in vinculin to give an ‘open’ form, which promotes nuclear localization of Yes-associated protein (YAP, also...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (3): jcs210237.
Published: 2 February 2018
... of multiple actin-based structures, likely by regulation of integrin signaling. Changes in focal adhesion organization and basal actin stress fibers in MRP-knockout (KO) cells were reminiscent of those seen in FAK-KO cells. In addition, we found alterations in cell–cell interactions in MRP-KO cells associated...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2017) 130 (20): 3517–3531.
Published: 15 October 2017
...) constitute an adaptor protein family called the vinexin (SORBS) family that is targeted to focal adhesions (FAs). Although numerous studies have focused on each of the SORBS proteins and partially elucidated their involvement in mechanotransduction, a comparative analysis of their function has not been well...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (14): 2382–2393.
Published: 15 July 2017
... by The Company of Biologists Ltd 2017 http://www.biologists.com/user-licence-1-1/ Summary: ARHGAP42 is activated by Src-mediated Tyr-376 phosphorylation to inhibit RhoA, and promote focal adhesion dynamics and cell motility. Src Motility RhoA GAP GRAF Focal adhesion Tyrosine...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Adhesion
J Cell Sci (2017) 130 (9): 1612–1624.
Published: 1 May 2017
...Ben Stutchbury; Paul Atherton; Ricky Tsang; De-Yao Wang; Christoph Ballestrem ABSTRACT Focal adhesions (FAs) are macromolecular complexes that regulate cell adhesion and mechanotransduction. By performing fluorescence recovery after photobleaching (FRAP) and fluorescence loss after photoactivation...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Cell Migration
J Cell Sci (2016) 129 (21): 4105–4117.
Published: 1 November 2016
.../ Summary: Translation affects adhesion and invasion potential of spreading initiation centers (SICs) producing mesenchymal cells, but not epithelial cells, which are deprived of SICs Spreading initiation centers SICs RNA-binding proteins Focal adhesion Translation regulation Invasion...
Includes: Supplementary data