1-20 of 69
Keywords: Focal adhesion
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
In collection:
Adhesion , Cytoskeleton
J Cell Sci (2022) 135 (11): jcs259465.
Published: 6 June 2022
...Alba Zuidema; Wei Wang; Maaike Kreft; Onno B. Bleijerveld; Liesbeth Hoekman; Jonas Aretz; Ralph T. Böttcher; Reinhard Fässler; Arnoud Sonnenberg ABSTRACT The vitronectin receptor integrin αVβ5 can reside in two distinct adhesion structures – focal adhesions (FAs) and flat clathrin lattices (FCLs...
Includes: Supplementary data
Journal Articles
In collection:
Cell Migration
J Cell Sci (2022) 135 (4): jcs259138.
Published: 18 February 2022
... et al., 2016 ; Kadir et al., 2016 ; Orosco et al., 2014 ). Cell migration involves cell polarization to develop a leading and a trailing end, followed by recruitment of the actin cytoskeleton and formation of cell protrusions and focal adhesions (FAs) at the leading edge. FAs are large...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion , Imaging
J Cell Sci (2022) 135 (3): jcs259430.
Published: 3 February 2022
... contain the non-neuronal proteins LL5β (also known as PHLDB2) and KANK1, which, in migrating cells, organize exocytotic machinery in the vicinity of integrin-based adhesions. Depletion of LL5β or focal adhesion disassembly triggered by myosin II inhibition perturbed the clustering of secretory complexes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (4): jcs254029.
Published: 17 February 2021
...Yi-Chun Liao; Su Hao Lo ABSTRACT Tensins are a family of focal adhesion proteins consisting of four members in mammals (TNS1, TNS2, TNS3 and TNS4). Their multiple domains and activities contribute to the molecular linkage between the extracellular matrix and cytoskeletal networks, as well...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (9): jcs240077.
Published: 14 May 2020
..., mitogen-activated protein 4 kinase 4 (MAP4K4) was identified as important novel mediator of endothelial permeability, which signaled via ezrin, radixin and moesin proteins to increase turnover of integrin-based focal adhesions. The combined inhibition of MAP4K4 and Abl-related gene (Arg, also known...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2020) 133 (1): jcs231134.
Published: 3 January 2020
...-mediated activation of FAK and recruitment of zyxin at focal adhesions in keratinocytes ( Eberwein et al., 2015 ). However, p190RhoGAP (herein referring to ARHGAP35 and ARHGAP5) was also found to be highly activated in these conditions, which would translate to decreased RhoA activity and therefore reduced...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion , Cytoskeleton
J Cell Sci (2019) 132 (19): jcs232843.
Published: 9 October 2019
... their participation in adhesion turnover and cellular signalling. In this Review, we focus on the interactions between microtubules and integrin-mediated adhesions, in particular, focal adhesions and podosomes. Starting with the association of microtubules with these adhesive structures, we describe the classical...
Journal Articles
J Cell Sci (2019) 132 (17): jcs225383.
Published: 2 September 2019
... density of inward-rectifier K + channels (K ir 2.1; encoded by KCNJ2 ) and profoundly alter the action potential shape of excitable cells. By using micropatterning to manipulate the localization and size of focal adhesions (FAs) in single HEK293 cells engineered to stably express K ir 2.1 channels...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (7): jcs226514.
Published: 3 April 2019
...   15 , 293 . 10.1186/1471-2105-15-293 Bell , S. and Terentjev , E. M. ( 2017 ). Focal adhesion kinase: the reversible molecular Mechanosensor . Biophys. J.   112 , 2439 - 2450 . 10.1016/j.bpj.2017.04.048 Benito-Jardón , M. , Klapproth , S. , Gimeno-Lluch , I...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2019) 132 (2): jcs217349.
Published: 21 January 2019
... gene), both of which localize to focal adhesions, cooperatively function as mechanosensors of ECM stiffness. On a rigid ECM, vinexin α interacts with vinculin and induces a conformational change in vinculin to give an ‘open’ form, which promotes nuclear localization of Yes-associated protein (YAP, also...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (3): jcs210237.
Published: 2 February 2018
... of multiple actin-based structures, likely by regulation of integrin signaling. Changes in focal adhesion organization and basal actin stress fibers in MRP-knockout (KO) cells were reminiscent of those seen in FAK-KO cells. In addition, we found alterations in cell–cell interactions in MRP-KO cells associated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (1): jcs205393.
Published: 4 January 2018
... of the accumulated integrins. Mechanistically, ADAM9 co-immunoprecipitates with β1 integrin, and both internalization and subsequent degradation of β1 integrin are significantly decreased in ADAM9-silenced cells, with no effect on β1 integrin recycling. Accordingly, the formation of focal adhesions and actin stress...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (20): 3517–3531.
Published: 15 October 2017
...) constitute an adaptor protein family called the vinexin (SORBS) family that is targeted to focal adhesions (FAs). Although numerous studies have focused on each of the SORBS proteins and partially elucidated their involvement in mechanotransduction, a comparative analysis of their function has not been well...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (14): 2382–2393.
Published: 15 July 2017
... - 793 . 10.1038/nature00859 Fincham , V. J. and Frame , M. C. ( 1998 ). The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility . EMBO J.   17 , 81 - 92 . 10.1093/emboj/17.1.81...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (12): 2036–2048.
Published: 15 June 2017
... cells significantly reduced invadopodia formation and matrix degradation, and simultaneously increased overall cell adhesion to the ECM. Live-imaging analysis showed that knockdown of ADAM12 significantly inhibited focal adhesion turnover. Mechanistically, both the disintegrin and metalloproteinase...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2017) 130 (9): 1612–1624.
Published: 1 May 2017
...Ben Stutchbury; Paul Atherton; Ricky Tsang; De-Yao Wang; Christoph Ballestrem ABSTRACT Focal adhesions (FAs) are macromolecular complexes that regulate cell adhesion and mechanotransduction. By performing fluorescence recovery after photobleaching (FRAP) and fluorescence loss after photoactivation...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2017) 130 (7): 1263–1273.
Published: 1 April 2017
...Peta M. Bradbury; Kylie Turner; Camilla Mitchell; Kaitlyn R. Griffin; Shiloh Middlemiss; Loretta Lau; Rebecca Dagg; Elena Taran; Justin Cooper-White; Ben Fabry; Geraldine M. O'Neill ABSTRACT Members of the Cas family of focal adhesion proteins contain a highly conserved C-terminal focal adhesion...
Journal Articles
In collection:
Cell Migration
J Cell Sci (2016) 129 (21): 4105–4117.
Published: 1 November 2016
...://www.biologists.com/user-licence-1-1/ Summary: Translation affects adhesion and invasion potential of spreading initiation centers (SICs) producing mesenchymal cells, but not epithelial cells, which are deprived of SICs Spreading initiation centers SICs RNA-binding proteins Focal adhesion...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
J Cell Sci (2016) 129 (20): 3685–3693.
Published: 15 October 2016
... work demonstrates that selective autophagy mediated by the autophagy cargo receptor, NBR1, specifically promotes the dynamic turnover of integrin-based focal adhesion sites during motility. Here, we discuss the detailed mechanisms through which NBR1-dependent selective autophagy supports focal adhesion...
Journal Articles
In collection:
Adhesion , Imaging
J Cell Sci (2016) 129 (16): 3115–3129.
Published: 15 August 2016
... functions is not well understood. Here, we show that Prickle1 regulates front-rear polarization and migration of gastric cancer MKN1 cells. Prickle1 preferentially accumulated at the cell retraction site in close proximity to paxillin at focal adhesions. Prickle1 dynamics correlated with those of paxillin...
Includes: Supplementary data