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Keywords: Focal adhesion
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Journal Articles
J Cell Sci (2021) 134 (4): jcs254029.
Published: 17 February 2021
...Yi-Chun Liao; Su Hao Lo ABSTRACT Tensins are a family of focal adhesion proteins consisting of four members in mammals (TNS1, TNS2, TNS3 and TNS4). Their multiple domains and activities contribute to the molecular linkage between the extracellular matrix and cytoskeletal networks, as well...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (9): jcs240077.
Published: 14 May 2020
..., mitogen-activated protein 4 kinase 4 (MAP4K4) was identified as important novel mediator of endothelial permeability, which signaled via ezrin, radixin and moesin proteins to increase turnover of integrin-based focal adhesions. The combined inhibition of MAP4K4 and Abl-related gene (Arg, also known...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2020) 133 (1): jcs231134.
Published: 03 January 2020
... 2019 © 2020. Published by The Company of Biologists Ltd 2020 http://www.biologists.com/user-licence-1-1/ Highlighted Article: Intracellular transglutaminase 2 influences cellular mechanical state, focal adhesion dynamic and FAK activation in response to substrate stiffness, in part...
Includes: Supplementary data
Journal Articles
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Adhesion , Cytoskeleton
J Cell Sci (2019) 132 (19): jcs232843.
Published: 09 October 2019
... their participation in adhesion turnover and cellular signalling. In this Review, we focus on the interactions between microtubules and integrin-mediated adhesions, in particular, focal adhesions and podosomes. Starting with the association of microtubules with these adhesive structures, we describe the classical...
Journal Articles
J Cell Sci (2019) 132 (17): jcs225383.
Published: 02 September 2019
... density of inward-rectifier K + channels (K ir 2.1; encoded by KCNJ2 ) and profoundly alter the action potential shape of excitable cells. By using micropatterning to manipulate the localization and size of focal adhesions (FAs) in single HEK293 cells engineered to stably express K ir 2.1 channels...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (7): jcs226514.
Published: 03 April 2019
... regulates adhesion complex composition and phosphotyrosine signaling. Talin rod subdomains and their mechanical activation are required for cell polarization and migration. BioID Focal adhesion Mechanobiology Phosphoproteomics Protein engineering Talin Focal adhesions are complex...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2019) 132 (2): jcs217349.
Published: 21 January 2019
... gene), both of which localize to focal adhesions, cooperatively function as mechanosensors of ECM stiffness. On a rigid ECM, vinexin α interacts with vinculin and induces a conformational change in vinculin to give an ‘open’ form, which promotes nuclear localization of Yes-associated protein (YAP, also...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (3): jcs210237.
Published: 02 February 2018
... of multiple actin-based structures, likely by regulation of integrin signaling. Changes in focal adhesion organization and basal actin stress fibers in MRP-knockout (KO) cells were reminiscent of those seen in FAK-KO cells. In addition, we found alterations in cell–cell interactions in MRP-KO cells associated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (1): jcs205393.
Published: 04 January 2018
... of the accumulated integrins. Mechanistically, ADAM9 co-immunoprecipitates with β1 integrin, and both internalization and subsequent degradation of β1 integrin are significantly decreased in ADAM9-silenced cells, with no effect on β1 integrin recycling. Accordingly, the formation of focal adhesions and actin stress...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (20): 3517–3531.
Published: 15 October 2017
...) constitute an adaptor protein family called the vinexin (SORBS) family that is targeted to focal adhesions (FAs). Although numerous studies have focused on each of the SORBS proteins and partially elucidated their involvement in mechanotransduction, a comparative analysis of their function has not been well...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (14): 2382–2393.
Published: 15 July 2017
...-licence-1-1/ Summary: ARHGAP42 is activated by Src-mediated Tyr-376 phosphorylation to inhibit RhoA, and promote focal adhesion dynamics and cell motility. Src Motility RhoA GAP GRAF Focal adhesion Tyrosine phosphorylation Src is a nonreceptor protein tyrosine kinase...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (12): 2036–2048.
Published: 15 June 2017
... cells significantly reduced invadopodia formation and matrix degradation, and simultaneously increased overall cell adhesion to the ECM. Live-imaging analysis showed that knockdown of ADAM12 significantly inhibited focal adhesion turnover. Mechanistically, both the disintegrin and metalloproteinase...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2017) 130 (9): 1612–1624.
Published: 01 May 2017
...Ben Stutchbury; Paul Atherton; Ricky Tsang; De-Yao Wang; Christoph Ballestrem ABSTRACT Focal adhesions (FAs) are macromolecular complexes that regulate cell adhesion and mechanotransduction. By performing fluorescence recovery after photobleaching (FRAP) and fluorescence loss after photoactivation...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2017) 130 (7): 1263–1273.
Published: 01 April 2017
...Peta M. Bradbury; Kylie Turner; Camilla Mitchell; Kaitlyn R. Griffin; Shiloh Middlemiss; Loretta Lau; Rebecca Dagg; Elena Taran; Justin Cooper-White; Ben Fabry; Geraldine M. O'Neill ABSTRACT Members of the Cas family of focal adhesion proteins contain a highly conserved C-terminal focal adhesion...
Journal Articles
In collection:
Cell Migration
J Cell Sci (2016) 129 (21): 4105–4117.
Published: 01 November 2016
.../ Summary: Translation affects adhesion and invasion potential of spreading initiation centers (SICs) producing mesenchymal cells, but not epithelial cells, which are deprived of SICs Spreading initiation centers SICs RNA-binding proteins Focal adhesion Translation regulation Invasion...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
J Cell Sci (2016) 129 (20): 3685–3693.
Published: 15 October 2016
... work demonstrates that selective autophagy mediated by the autophagy cargo receptor, NBR1, specifically promotes the dynamic turnover of integrin-based focal adhesion sites during motility. Here, we discuss the detailed mechanisms through which NBR1-dependent selective autophagy supports focal adhesion...
Journal Articles
In collection:
Adhesion , Imaging
J Cell Sci (2016) 129 (16): 3115–3129.
Published: 15 August 2016
... functions is not well understood. Here, we show that Prickle1 regulates front-rear polarization and migration of gastric cancer MKN1 cells. Prickle1 preferentially accumulated at the cell retraction site in close proximity to paxillin at focal adhesions. Prickle1 dynamics correlated with those of paxillin...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2016) 129 (10): 1981–1988.
Published: 15 May 2016
...Aneesh R. Sathe; G. V. Shivashankar; Michael P. Sheetz ABSTRACT The nuclear transport of paxillin appears to be crucial for paxillin function but the mechanism of transport remains unclear. Here, we show that the nuclear transport of paxillin is regulated by focal adhesion turnover and the presence...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2016) 129 (10): 2016–2029.
Published: 15 May 2016
... melastatin 2 (TRPM2) Ca 2+ channel serves as a molecular link between H 2 O 2 and Ca 2+ . H 2 O 2 -mediated activation of TRPM2 channels induced filopodia formation, loss of actin stress fibres and disassembly of focal adhesions, leading to increased migration of HeLa and prostate cancer (PC)-3 cells...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2016) 129 (8): 1734–1749.
Published: 15 April 2016
... membrane transport to the plasma membrane. Here, we developed a high-content analysis (HCA) tool to dissect Rab8-mediated actin and focal adhesion reorganization that revealed that Rab8 activation significantly induced Rac1 and Tiam1 to mediate cortical actin polymerization and RhoA-dependent stress fibre...
Includes: Supplementary data